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Improved antibacterial and antioxidant activities of gallic acid grafted chitin-glucan complex

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Abstract

In this study, we have developed phenolic acid grafted chitin-glucan complex via new, simple and effective free radical mediated method by using gallic acid (GA) and chitin-glucan complex. The chemical structure of Gallic acid grafted chitin-glucan complex (GA-g-chitin-glucan complex) was characterized by proton nuclear magnetic resonance (1H-NMR) and Fourier-transform infrared spectroscopy (FT-IR). X-ray diffraction (XRD) result showed that after grafting crystallinity of chitin-glucan complex decreases and rough and porous morphology was observed by Scanning electron microscopy (SEM) due to decreased hydrogen bonds. GA-g-chitin-glucan complex showed excellent biocompatible, better antibacterial activity, and tremendous antioxidant activity in comparison to unmodified chitin-glucan complex. Antibacterial result showed better inhibitory properties of GA-g-chitin-glucan complex than that of unmodified chitin-glucan complex. In antioxidant activity, GA-g-chitin-glucan complex was much higher than chitin-glucan complex examined by two different methods DPPH and ABTS radical scavenging activities. It gives 93.23% for DPPH and 94.63% for ABTS scavenging activity. Therefore, it is expected that GA-g-chitin-glucan complex would be highly applicable in biomedical areas.

Synthesis of GA-g-chitin-glucan complex and its antibacterial & antioxidant property

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Acknowledgements

The authors are thankful to MNNIT, Allahabad for the financial support for this research and providing stipend to AS.

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Authors and Affiliations

  1. Polymer Research Laboratory, Department of Chemistry, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India

    Anu Singh, P. K. Dutta & Hridyesh Kumar

  2. Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India

    Amit Kumar Kureel & Ambak Kumar Rai

Authors
  1. Anu Singh
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  2. P. K. Dutta
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  3. Hridyesh Kumar
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  4. Amit Kumar Kureel
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  5. Ambak Kumar Rai
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Correspondence to P. K. Dutta.

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Highlights

• Antibacterial and antioxidant properties containing Gallic acid grafted chitin-glucan complex have been developed via free radical grafting method.

• Safe, biocompatible, non-toxic, polymeric conjugate for biomedical application.

• Gallic acid grafted chitin-glucan complex may be useful for food technology.

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Singh, A., Dutta, P.K., Kumar, H. et al. Improved antibacterial and antioxidant activities of gallic acid grafted chitin-glucan complex. J Polym Res 26, 234 (2019). https://doi.org/10.1007/s10965-019-1893-3

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  • DOI: https://doi.org/10.1007/s10965-019-1893-3

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