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Construction and evaluation of the hydroxypropyl methyl cellulose-sodium alginate composite hydrogel system for sustained drug release

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Abstract

We prepared a hydroxypropyl methyl cellulose-sodium alginate (HPMC-SA) composite hydrogel with a membrane covering the semi-interpenetrating network based on a semi-synthetic polymer hydroxypropyl methyl cellulose (HPMC) and a natural polymer sodium alginate (SA) by Ca2+ crosslinking and polyelectrolyte complexation with chitosan (CS) covering the hydrogel surface. The physiochemical properties of HPMC-SA hydrogels were evaluated by scanning electron microscopy, infrared spectrum, X-ray diffraction, and thermogravimetric analysis. The swelling ratio of the HPMC-SA composite hydrogel in simulated gastrointestinal fluid was measured. The drug release behavior of the HPMC-SA composite hydrogel for macro-molecular and small-molecule drugs was evaluated by using bovine serum albumin, metformin hydrochloride, and indomethacin as model drugs. The results showed that the HPMC-SA hydrogel had good water absorption and degradability, an increased swelling ratio of 55, and a prolonged time for maximum swelling degree of 50 h. Moreover, the hydrogel exhibited higher drug-loading capacity and improvements in the sustained release of bio-macromolecules, demonstrating its potential as a drug carrier for biomedical applications.

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Acknowledgements

The authors are grateful to the financial support from the National Natural Science Foundation of China (No.81401510), Hubei Provincial Natural Science Foundation of China (2017CFB414), the academic team of South-central University for Nationalities (CZW15017), the Fundamental Research Funds for the Central Universities, South-Central University for Nationalities (CZP17092) and the National College Students Innovation and entrepreneurship training project (SCX1727).

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Authors and Affiliations

  1. School of Pharmaceutical Science, South-Central University for Nationalities, Wuhan, 430074, People’s Republic of China

    Yan Hu, Shangwen Zhang, Dandan Han, Zongxian Ding, Suying Zeng & Xincai Xiao

  2. National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, Wuhan, 430074, People’s Republic of China

    Yan Hu, Shangwen Zhang, Dandan Han, Zongxian Ding, Suying Zeng & Xincai Xiao

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  1. Yan Hu
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  2. Shangwen Zhang
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Correspondence to Yan Hu.

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Hu, Y., Zhang, S., Han, D. et al. Construction and evaluation of the hydroxypropyl methyl cellulose-sodium alginate composite hydrogel system for sustained drug release. J Polym Res 25, 148 (2018). https://doi.org/10.1007/s10965-018-1546-y

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  • DOI: https://doi.org/10.1007/s10965-018-1546-y

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