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Autism Spectrum Disorders: Pharmacotherapy for Challenging Behaviors

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Abstract

Autism spectrum disorders, a group of five conditions with similar behavioral characteristics, have received increasing research attention in recent years. Treatments have been successful at least to remediate or improve some symptoms, and the amount of research on the topic has been escalating very rapidly. The two primary forms of intervention studied the most to date have been applied behavior analysis and behavior therapy, and psychopharmacology. The purpose of this paper was to review efficacy of this latter category: drug related interventions for challenging behaviors. Effectiveness of these treatments based on the available research literature are reviewed with respect to current strengths and weaknesses of various psychotropic drug interventions. Trends in the data and potential future directions for research are discussed, including types of drugs used, targets for intervention, the future of combined behavior and drug interventions, and the measurement of side effects in psychopharmacology.

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References

  • Adetunji, B., Matthews, M., Osinowo, T., & Williams, A. (2006). Risperidone for the core symptom domains of autism. American Journal of Psychiatry, 163, 551.

    PubMed  Google Scholar 

  • Aman, M. G., & Langworthy, K. S. (2000). Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders. Journal of Autism and Developmental Disorders, 30, 451–459.

    PubMed  Google Scholar 

  • Aman, M. G., van Bourgondien, M. E., Wolford, P. L., & Sarphare, G. (1995). Psychotropic and anticonvulsant drugs in subjects with autism: Prevalence and patterns of use. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1672–1681.

    PubMed  Google Scholar 

  • American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders, text revision (4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Anderson, L. T., Campbell, M., Adams, P., Small, A. M., Perry, R., & Shell, J. (1989). The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children. Journal of Autism and Developmental Disorders, 19, 227–239.

    PubMed  Google Scholar 

  • Anderson, L. T., Campbell, M., Grega, D. M., Perry, R., Small, A. M., & Green, W. T. (1984). Haloperidol in the treatment of infantile autism: Effects on learning and behavioral symptoms. American Journal of Psychiatry, 141, 1195–1202.

    PubMed  Google Scholar 

  • Arnold, L. E., Vitiello, B., McDougle, C., Scahill, L., Bhavik, S., Nilda, G., et al. (2003). Parent-defined target symptoms respond to risperidone in RVPP autism study: Customer approach to clinical trials. Journal of American Academy of Child and Adolescent Psychiatry, 42, 1443–1450.

    Google Scholar 

  • Barbaresi, W. J., Katusic, S. K., & Voight, R. G. (2006). Autism: A review of the state of the science for pediatric primary health care clinicians. Archives of Pediatric and Adolescent Medicine, 160, 1167–1175.

    Google Scholar 

  • Bardenstein, R., Chez, M., Helfaud, B., Buchanan, S. P., & Zucker, M. (1998). Improvement in EEG and clinical function in pervasive developmental delay (PDD): Effect of valproic acid. Annals of Neurology, 50(4), (Supplement), 86.

    Google Scholar 

  • Barnard, L., Young, A. H., Pearson, J., Geddes, J., & O’Brien, G. (2002). A systematic review of the use of atypical antipsychotics in autism. Journal of Psychopharmacology, 16, 93–101.

    PubMed  Google Scholar 

  • Belsito, K. M., Law, P. A., Kirk, K. S., Landa, R. J., & Zimmerman, A. W. (2001). Lamotrigine therapy for autistic disorder: A randomized, double-blind placebo-controlled trial. Journal of Autism and Developmental Disorders, 31, 175–181.

    PubMed  Google Scholar 

  • Ben-Itzchak, E., & Zachor, D. A. (2007). The effects of intellectual functioning and autism severity on outcome of early behavioral intervention for children with autism. Research in Developmental Disabilities, 28, 287–303.

    PubMed  Google Scholar 

  • Boon-Yasidhi, V., Tarugsa, J., Suwanwattana, C., & Soising, L. (2002). Risperidone in the treatment of autistic Thai children under 4 years of age. Journal of the Medical Association of Thailand, 85(Supplement 2), 5784–5789.

    Google Scholar 

  • Broadstock, M., & Doughty, C. (2003). The effectiveness of pharmacological therapies for young people and adults with Autism Spectrum Disorder (ASD). New Zealand Health Technology Assessment (NZHTA) Report 2003 6(1).

  • Bryson, S. E., Rogers, S. J., & Fombonne, E. (2003). Autism spectrum disorders: Early detection, intervention, education and psychopharmacological management. Canadian Journal of Psychiatry, 48, 506–516.

    Google Scholar 

  • Canella, H. I., O’Reilly, M. F., & Lancioni, G. E. (2006). Treatment of hand mouthing in individuals with severe to profound developmental disabilities: A review of the literature. Research in Developmental Disabilities, 27, 529–544.

    Google Scholar 

  • Chavez, B., Chavez-Brown, M., & Rey, J. A. (2006). Role of risperidone in children with autism spectrum disorders. The Annals of Pharmacotherapy, 40, 909–916.

    PubMed  Google Scholar 

  • Chen, N. C., Bedair, H. S., McKay, B., Bowers, M. B., & Mazure, C. (2001). Clozapine in the treatment of aggression in an adolescent with autistic disorder. Journal of Clinical Psychiatry, 62, 479–480.

    Article  PubMed  Google Scholar 

  • Chez, M. G., Memon, S., & Hung, P. C. (2004). Neurologic treatment strategies in autism: An overview of medical intervention strategies. Seminars in Pediatric Neurology, 11, 229–235.

    PubMed  Google Scholar 

  • Chung, M. C., Cumella, S., Bickerton, W. L., & Winchester, C. (2003). The prevalence of aggressive behaviors in the hospital, the family and the communitarian residences. The European Journal of Psychiatry, 17, 1–14.

    Google Scholar 

  • Coghill, D. (2002). Evidence-based psychopharmacology for children and adolescents. Current Opinion in Psychiatry, 15, 361–368.

    Google Scholar 

  • Coghill, D. (2003). Current issues in child and adolescent psychopharmacology. Part 2: Anxiety and obsessive-compulsive disorders, autism, Tourette’s and schizophrenia. Advances in Psychiatric Treatment, 9, 289–299.

    Google Scholar 

  • Cook, E. H., Rowlett, R., Jaselskis, C., & Leventhal, B. L. (1992). Fluoxetine treatment of children and adults with autistic disorder and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 739–745.

    PubMed  Google Scholar 

  • DeLong, G. R., Teague, L. A., & McSwain-Kamran, M. (1998). Effects of fluoxetine treatment in young children with idiopathic autism. Developmental Medicine and Child Neurology, 4, 551–562.

    Google Scholar 

  • DiMartino, A., & Tuchman, R. F. (2001). Antiepileptic drugs: Affective use in autism spectrum disorders. Pediatric Neurology, 25, 199–207.

    Google Scholar 

  • Dinca, O., Paul, M., & Spencer, N. J. (2005). Systematic review of randomized controlled trials of atypical antipsychotics and selective serotonin reuptake inhibitors for behavioural problems associated with pervasive developmental disorders. Journal of Psychopharmacology, 19, 521–532.

    PubMed  Google Scholar 

  • Dominick, K. C., Davis, N. O., Lainhart, J., Tager-Flusberg, H., & Folstein, S. (2007). Atypical behavior in children with autism and children with a history of language impairment. Research in Developmental Disabilities, 28, 145–162.

    PubMed  Google Scholar 

  • Edelson, M. G. (2006). Are the majority of children with autism mentally retarded. Focus on Autism and Other Developmental Disabilities, 21, 66–83.

    Article  Google Scholar 

  • Ellis, E. M., Ala’i-Rosales, S. S., Glenn, S. S., Rosales-Ruiz, J., & Greenspoon, J. (2006). The effects of graduated exposure, modeling, and contingent social attention on tolerance to skin care products with two children with autism. Research in Developmental Disabilities, 27, 585–598.

    PubMed  Google Scholar 

  • Fatemi, S. H., Realmuto, G. M., Khan, L., & Thuras, P. (1998). Fluoxetine in treatment of adolescent patients with autism: A longitudinal open trial. Journal of Autism and Developmental Disorders, 28, 303–307.

    PubMed  Google Scholar 

  • Feroz-Nainar, C., & Roy, M. (2006). Risperidone and late onset tics. Autism, 10, 679–685.

    Google Scholar 

  • Filipek, P. A., Steinberg-Epstein, R., & Book, T. M. (2006). Interventions for autism spectrum disorders. The Journal of the American Society for Experimental NeuroTherapeutics, 3, 207–216.

    Google Scholar 

  • Findling, R. L., Aman, M. G., Eerdekens, M., Derivan, A., Lyons, B., The Risperidone Disruptive Behavior Study Group (2004). Long-term, open-label study of Risperidone in children with severe disruptive behavior and below average I.Q. American Journal of Psychiatry, 161, 677–684.

    PubMed  Google Scholar 

  • Findling, R. L., McNamara, N. K., Branicky, L. A., Schluchter, M. D., Lemon, E., & Blumer, J. L. (2000). A double-blind pilot study of risperidone in the treatment of conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 509–516.

    PubMed  Google Scholar 

  • Fishman, S., & Steele, M. (1996). Use of risperidone in pervasive developmental disorders: A case series. Journal of Child and Adolescent Psychopharmacology, 6, 177–190.

    Google Scholar 

  • Folstein, S., & Santangelo, S. (2000). Does Asperger syndrome aggregate in families? In A. Klin, F. R. Volkmar, & S. Sparrow (Eds.), Asperger syndrome (pp. 159–171). New York: Guilford.

    Google Scholar 

  • Fombonne, E. (1999). The epidemiology of autism: A review. Psychological Medicine, 29, 726–728.

    Google Scholar 

  • Fombonne, E. (2006). Risperidone improves restricted, repetitive and stereotyped behaviors in autistic children and adolescents. Evidence Based Mental Health, 9, 6.

    Article  PubMed  Google Scholar 

  • Fountoulakis, K. N., Nimatoudis, I., Iacovides, A., & Kaprinis, G. (2004). Off-label indications for atypical antipsychotics: A systematic review. Annals of General Hospital Psychiatry, 3, 1–10.

    Google Scholar 

  • Gagliano, A., Germano, E., Pastorino, G., Impallomeni, C., D’Arrigo, C., Calamoneri, F., et al. (2004). Risperidone treatment of children with autistic disorder: Effectiveness, tolerability and pharmacokinetic implications. Journal of Child and Adolescent Psychopharmacology, 14, 39–47.

    PubMed  Google Scholar 

  • Gerlai, R., & Gerlai, J. (2004). Autism: A target of pharmacotherapies? Drug Discovery Today, 9, 366–374.

    PubMed  Google Scholar 

  • Goin-Kochel, R. P., Myers, B. J., & Mackintosh, V. H. (2007). Parental reports on the use of treatments and therapies for children with autism spectrum disorders. Research in Autism Spectrum Disorders, 10, 439–451.

    Google Scholar 

  • Gordon, C. T., Rapoport, J. L., Hamburger, S. D., State, R. C., & Mannheim, G. B. (1992). Differential response of seven subjects with autistic disorder to clomipramine and desipramine. American Journal of Psychiatry, 149, 363–366.

    PubMed  Google Scholar 

  • Gordon, C. T., State, R. C., Nelson, J. E., Hamburger, S. D., & Rapoport, J. L. (1993). A double-blind comparison of clomipramine, desipramine and placebo in the treatment of autistic disorder. Archives of General Psychiatry, 50, 441–447.

    PubMed  Google Scholar 

  • Green, V. A., Pituch, K. A., Itchon, J., Choi, A., O’Reilly, M., & Sigafoos, J. (2006). Internet survey of treatments used by parents of children with autism. Research in Developmental Disabilities, 27, 70–84.

    PubMed  Google Scholar 

  • Handen, B. L., & Lubetsky, M. (2005). Pharmacotherapy in autism and related disorders. School Psychology Quarterly, 20, 155–171.

    Google Scholar 

  • Hardan, A., Johnson, K., Johnson, C., & Hrecznyj, B. (1996). Case study: Risperidone treatment of children and adolescents with developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1551–1556.

    PubMed  Google Scholar 

  • Hellings, J. A., Kelley, L. A., Gabrielli, W. F., Kilgore, E., & Shah, P. (1996). Sertraline response in adults with mental retardation and autistic disorder. Journal of Clinical Psychiatry, 57, 333–336.

    PubMed  Google Scholar 

  • Hellings, J. A., Zarcone, J. R., Crandall, K., Wallace, D., & Schroeder, S. R. (2001). Weight gain in a controlled study of risperidone in children, adolescents and adults with mental retardation and autism. Journal of Child and Adolescent Psychopharmacology, 11, 229–238.

    PubMed  Google Scholar 

  • Herrington, J. D., Baron-Cohen, S., Wheelwright, S. J., Singh, K. D., Bullmore, E. T., Brammer, M., et al. (2007). The role of MT+VS during biological motion perception in Asperger syndrome: An fMRI study. Research in Autism Spectrum Disorders, 1, 14–27.

    Google Scholar 

  • Hill, J., & Furniss, F. (2006). Patterns of emotional and behavioural disturbance associated with autistic traits in young people with severe intellectual disabilities and challenging behaviours. Research in Developmental Disabilities, 27, 517–528.

    PubMed  Google Scholar 

  • Hilton, C., Graver, K., & LaVesser, P. (2007). Relationship between social competence and sensory processing in children with high functioning autism spectrum disorders. Research in Autism Spectrum Disorders, 1, 164–173.

    Google Scholar 

  • Hoch, J., & Symons, F. J. (2007). Matching analysis of socially appropriate and destructive behavior in developmental disabilities. Research in Developmental Disabilities, 28, 238–248.

    PubMed  Google Scholar 

  • Holden, B., & Gitlesen, J. P. (2006). A total population study of challenging behaviour in the country of Hedmark, Norway: Prevalence and risk markers. Research in Developmental Disabilities, 27, 456–465.

    PubMed  Google Scholar 

  • Hollander, E., Kaplan, A., Cartwright, C., & Reichman, D. (2000). Venlafaxine in children, adolescents, and young adults with autism spectrum disorders: An open retrospective clinical report. Journal of Child Neurology, 15, 132–135.

    PubMed  Google Scholar 

  • Hughes, D. M. (2002). Risperidone in children and adolescents with autistic disorder and aggressive behaviour. British Journal of Developmental Disabilities, 48, 113–122.

    Google Scholar 

  • Hunsinger, D. M., Nguyen, T., Zebraski, S. E., & Raffa, R. B. (2000). Is there a basic for novel pharmacotherapy in autism? Life Sciences, 67, 1667–1682.

    PubMed  Google Scholar 

  • Ingersoll, B., & Gergans, S. (2007). The effect of a parent-implemented imitation intervention on spontaneous imitation skills in young children with autism. Research in Developmental Disabilities, 28, 163–175.

    PubMed  Google Scholar 

  • Järbrink, K., McCrone, P., Fombonne, E., Zandén, H., & Knapp, M. (2007). Cost-impact of young adults with high-functioning autism spectrum disorders. Research in Developmental Disabilities, 28, 94–104.

    PubMed  Google Scholar 

  • Kabot, S., Masi, W., & Segal, M. (2003). Advances in the diagnosis and treatment of autism spectrum disorders. Professional Psychology: Research and Practice, 34, 26–33.

    Google Scholar 

  • Kemner, C., van Engeland, H., & Tuynman-Qua, H. (2000). An open-label study of olanzapine in children with PDD. Schizophrenia Research, 41, 194.

    Google Scholar 

  • Kerbeshian, J., Burd, L., & Avery, K. (2001). Pharmacotherapy of autism: A review and clinical approach. Journal of Developmental and Physical Disabilities, 13, 199–228.

    Google Scholar 

  • Kern, J. K., Garver, C. R., Grannemann, B. D., Trivedi, M. H., Carmody, T., Andrews, A. A., et al. (2007). Response to vestibular sensory events in autism. Research in Autism Spectrum Disorders, 1, 67–74.

    Google Scholar 

  • King, B. H. (2000). Pharmacological treatment of mood disturbances, aggression, and self-injury in persons with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 30, 439–445.

    PubMed  Google Scholar 

  • King, B. H., & Bostic, J. Q. (2006). An update on pharmacologic treatments for autism spectrum disorder. Child and Adolescent Psychiatry Clinics of North America, 15, 161–175.

    Google Scholar 

  • Koshes, R. J. (1997). Use of fluoxetine for obsessive-compulsive behavior in adults with autism. American Journal of Psychiatry, 154, 578.

    PubMed  Google Scholar 

  • Kwok, H. W. M. (2003). Psychopharmacology in autism spectrum disorders. Current Opinion in Psychiatry, 16, 529–534.

    Google Scholar 

  • Lam, K. S. L., Aman, M. G., & Arnold, L. E. (2006). Neurochemical correlates of autistic disorder: A review of the literature. Research in Developmental Disabilities, 27, 254–289.

    PubMed  Google Scholar 

  • Laud, R. B., & Matson, J. L. (2006). The relationship between manic symptoms on the DASH-II and YMRS and feeding/mealtime behavior problems. Research in Developmental Disabilities, 27, 559–566.

    PubMed  Google Scholar 

  • Levy, S. E., & Hyman, S. L. (2005). Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews, 11, 131–142.

    PubMed  Google Scholar 

  • Lewis, F. M., Murdoch, B. E., & Woodyatt, G. C. (2007). Linguistic abilities in children with autism spectrum disorders. Research in Autism Spectrum Disorders, 1, 85–100.

    Google Scholar 

  • MacDonald, R., Green, G., Mansfield, R., Geckeler, A., Gardenier, N., Anderson, J., et al. (2007). Stereotypy in young children with autism and typically developing children. Research in Developmental Disabilities, 28, 266–277.

    PubMed  Google Scholar 

  • Machalicek, W., O’Reilly, M. F., Beretvas, N., Sigafoos, J., & Lancioni, G. E. (2007). A review of interventions to reduce challenging behavior in school settings for students with autism spectrum disorders. Research in Autism Spectrum Disorders, 1, 229–246.

    Google Scholar 

  • Magnusson, P., & Saemundsen, E. (2001). Prevalence of autism in Iceland. Journal of Autism and Developmental Disorders, 31, 153–163.

    PubMed  Google Scholar 

  • Malone, R. P., Cater, J., Sheikh, R. M., Choudhury, M. S., & Delaney, M. A. (2001). Olanzapine versus haloperidol in children with autistic disorder: An open pilot study. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 887–894.

    PubMed  Google Scholar 

  • Malone, R. P., Ernst, M., Godfrey, K. A., Locascio, J. J., & Campbell, M. (1991). Repeated episodes of neuroleptic-related dyskinesias in autistic children. Psychopharmacology Bulletin, 27, 113–117.

    PubMed  Google Scholar 

  • Martin, A., Koenig, K., Anderson, G. M., & Scahill, L. (2003). Low-dose fluvoxamine treatment of children and adolescents with pervasive developmental disorders: A prospective, open-label study. Journal of Autism and Developmental Disorders, 33, 77–85.

    PubMed  Google Scholar 

  • Martin, A., Koenig, K., Scahill, L., & Bregman, J. (1999). Open-label quetiapine in the treatment of children and adolescents with autistic disorder. Journal of Child and Adolescent Psychopharmacology, 9, 99–107.

    PubMed  Google Scholar 

  • Masi, G. (2001). Risperidone monotherapy in preschool children with pervasive developmental disorders. Journal of Child Neurology, 16, 395–400.

    PubMed  Google Scholar 

  • Masi, G., Cosenza, A., & Mucci, M. (2001b). Prolactin levels in young children with pervasive developmental disorders during risperidone treatment. Journal of Child and Adolescent Psychopharmacology, 11, 389–394.

    PubMed  Google Scholar 

  • Masi, G., Cosenza, A., Mucci, M., & Brovedani, P. (2001). Open trial of risperidone in 24 young children with pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 1206–1214.

    PubMed  Google Scholar 

  • Masi, G., Cosenza, A., Mucci, M., & Brovedani, P. (2003). A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone. Journal of Clinical Psychiatry, 64, 1039–1047.

    Article  PubMed  Google Scholar 

  • Matson, J. L. (2007a). Current status of differential diagnosis for children with autism spectrum disorders. Research in Developmental Disabilities, 28, 109–118.

    PubMed  Google Scholar 

  • Matson, J. L. (2007b). Determining treatment outcome in early intervention programs for autism spectrum disorders: A critical analysis of measurement issues in learning based interventions. Research in Developmental Disabilities, 28, 207–218.

    PubMed  Google Scholar 

  • Matson, J. L., Cooper, C., Malone, C. J., & Moskow, S. L. (2007a). The relationship of self-injurious behavior and other maladaptive behaviors among individuals with severe and profound intellectual disability. Research in Developmental Disabilities (in press). DOI 10.10161j.ridd.2007.02.001.

  • Matson, J. L., González, M. L., Smith, K. R., Terlonge, C., Thorson, R. T., & Dixon, D. R. (2006). Assessing side effects of pharmacotherapy treatment of bipolar disorder: A 20-year review of the literature. Research in Developmental Disabilities, 27, 467–500.

    PubMed  Google Scholar 

  • Matson, J. L., & LoVullo, S. V. (2007). A review of the behavioral treatments for self-injurious behavior (SIB) of persons with autism spectrum disorders. Behavior Modification (in press).

  • Matson, J. L., & Minshawi, N. F. (2006). Early intervention for autism spectrum disorders. A critical analysis. Oxford, Engalnd: Elsevier.

    Google Scholar 

  • Matson, J. L., & Nebel-Schwalm, M. S. (2007). Comorbid psychopathology with autism spectrum disorders in children: An overview. Research in Developmental Disabilities, 28, 341–352.

    PubMed  Google Scholar 

  • Matson, J. L., Nebel-Schwalm, M., & Matson, M. L. (2007b). A review of methodological issues in the differential diagnosis of autism spectrum disorders in children. Research in Autism Spectrum Disorders, 1, 38–54.

    Google Scholar 

  • Matson, J. L., & Wilkins, J. (2007). A critical review of assessment targets and methods for social skills excesses and deficits for children with autism spectrum disorders. Research in Autism Spectrum Disorders, 1, 28–37.

    Google Scholar 

  • McCracken, J. T., McDougle, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., et al. (2002a). Risperidone in children with serious behavioral problems. The New England Journal of Medicine, 347, 314–321.

    PubMed  Google Scholar 

  • McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., et al. (2002b). Risperidone in children with autism and serious behavioral problems: Research units on pediatric psychopharmacology autism network. New England Journal of Medicine, 347, 314–321.

    PubMed  Google Scholar 

  • McDougle, C. J., Brodkin, E. S., Naylor, S. T., Carlson, D. C., Cohen, D. J., & Price, L. H. (1998). Sertraline in adults with pervasive developmental disorders: A prospective open-label investigation. Journal of Clinical Psychopharmacology, 18, 62–66.

    PubMed  Google Scholar 

  • McDougle, C. J., Holmes, J. P., & Bronson, M. R. (1997). Risperidone treatment of children and adolescents with pervasive developmental disorders: A prospective open-label study. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 685–693.

    PubMed  Google Scholar 

  • McDougle, C. J., Holmes, J. P., Carlson, D. C., Pelton, G. H., Cohen, D. J., & Price, L. H. (1998b). A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Archives of General Psychiatry, 55, 633–641.

    PubMed  Google Scholar 

  • McDougle, C. J., Kem, D. L., & Posey, D. J. (2002). Case series: Use of ziprasidone for maladaptive symptoms in youths with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 41, 921–927.

    PubMed  Google Scholar 

  • McDougle, C. J., Scahill, L., Aman, M. G., McCracken, J. T., Tierney, E., Davies, M., et al. (2005). Risperidone for the core symptoms of autism: Results from the study by the Autism Network of the Research Units on Pediatric Psychopharmacology. American Journal of Psychiatry, 162, 1142–1148.

    PubMed  Google Scholar 

  • McDougle, C. J., Stigler, K. A., Erickson, C. A., & Posey, D. J. (2006). Pharmacology in autism. Clinical Neuroscience Research, 6, 179–188.

    Google Scholar 

  • Metz, B., Mulick, J. A., & Butter, E. M. (2005). Autism: A late 20th century fad magnet. In J. W. Jacobson, R. M. Foxx, & J. A. Mulick (Eds.). Controversial therapies for developmental disabilities. Mahwah, NJ: Lawrence Erlbaum.

    Google Scholar 

  • Moran, R. W., & Gibbons, P. (2001). Intra-examiner and inter-examiner reliability for palpation of the cranial rhythmic impulse at the head and sacrum. Journal of Manipulative Physiological Therapy, 24, 183–190.

    Google Scholar 

  • Morgan, S., & Taylor, E. (2007). Antipsychotic drugs in children with autism. British Medical Journal, 334, 1069–1070.

    PubMed  Google Scholar 

  • Nicholson, J., Konstantinidi, E., & Furniss, F. (2006). On some psychometric properties of the questions about behavioral function (QABF) scale. Research in Developmental Disabilities, 27, 337–352.

    PubMed  Google Scholar 

  • Nicolson, R., Awad, G., & Sloman, L. (1998). An open trial of risperidone in young autistic children. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 372–376.

    PubMed  Google Scholar 

  • Palmero, M. T., & Curatolo, P. (2004). Pharmacologic treatment in autism. Journal of Child Neurology, 19, 155–164.

    Google Scholar 

  • Perry, R., Pataki, C., Munoz-Silva, D. M., Armenteros, R. R., & Silva, R. R. (1997). Risperidone in children and adolescents with pervasive developmental disorder: Pilot trial and follow-up. Journal of Child and Adolescent Psychopharmacology, 7, 167–179.

    PubMed  Google Scholar 

  • Plioplys, A. V. (1994). Autism: Electroencephalogram abnormalities and clinical improvement with valproic acid. Archives of Pediatric and Adolescent Medicine, 148, 220–222.

    Google Scholar 

  • Posey, D. J., Kem, D. L., Swiezy, N. B., Sweeten, T. L., Wiegand, R. E., & McDougle, C. J. (2004). A pilot study of d-cycloserine in subjects with autistic disorder. American Journal of Psychiatry, 161, 2115–2117.

    PubMed  Google Scholar 

  • Posey, D. J., & McDougle, C. J. (2000). The pharmacotherapy of target symptoms associated with autistic disorder and other pervasive developmental disorders. Harvard Review of Psychiatry, 8, 45–63.

    PubMed  Google Scholar 

  • Posey, D. J., Walsh, K. H., Wilson, G. A., & McDougle, C. J. (1999). Risperidone in the treatment of two very young children with autism. Journal of Child and Adolescent Psychopharmacology, 9, 273–276.

    PubMed  Google Scholar 

  • Potenza, M. N., Holmes, J. P., Kanes, S. J., & McDougle, C. (1999). Olanzapine treatment of children, adolescents, and adults with pervasive developmental disorders: An open-label pilot study. Journal of Clinical Psychopharmacology, 19, 37–44.

    PubMed  Google Scholar 

  • Poustka, L., & Poustka, F. (2007). Psychopharmakologie autistischer störungen. Kinder-und Jugend-psychiatrie und Psychotherapie, 35, 87–94.

    Google Scholar 

  • Research Units on Pediatric Psychopharmacology, Aut (2005). Risperidone treatment of autistic disorder: Longer-term benefits and blinded discontinuation after 6 months. American Journal of Psychiatry, 162, 1361–1369.

    Google Scholar 

  • Rojahn, J., Matson, J. L., Lott, D., Esbensen, A., & Smalls, Y. (2001). The Behavior Problem Inventory: An instrument for the assessment of self-injury, stereotyped behavior, and aggression/destruction in individuals with developmental disabilities. Journal of Autism and Developmental Disorders, 31, 558–577.

    Google Scholar 

  • Rutter, M. (1968). Concepts of autism: A review of research. Journal of Child Psychology and Psychiatry, 9, 1–25.

    PubMed  Google Scholar 

  • Sandler, L., Valiquette, G., Munarriz, R., Bennett, L., Goldstein, I., Scahill, L., et al., the Research Unit on Pediatric Psychopharmacology (2002). Risperidone in children with autism and serious behavioral problems. New England Journal of Medicine, 347, 1890–1891.

    PubMed  Google Scholar 

  • Schlosser, R. W., & Sigafoos, J. (2006). Augmentative and alternative communication interventions for persons with developmental disabilities: Narrative review of comparative single-subject experimental studies. Research in Developmental Disabilities, 27, 1–29.

    PubMed  Google Scholar 

  • Shattock, P., & Whitely, P. (2002). Biochemical aspects in autism spectrum disorders: Updating the opiod-excess theory and presenting new opportunities for biomedical intervention. Expert Opinion Therapy Targets, 6, 175–183.

    Google Scholar 

  • Siklos, S., & Kerus, K. A. (2007). Assessing the diagnostic experiences of a small sample of parents of children with autism spectrum disorders. Research in Developmental Disabilities, 28, 9–22.

    PubMed  Google Scholar 

  • Singh, N. N., Lancioni, G. E., Winton, A. S. W., Curtis, W. J., Wahler, R. G., Sabaawi, M., et al. (2006). Mindful staff increase learning and reduce aggression in adults with developmental disabilities. Research in Developmental Disabilities, 27, 545–558.

    PubMed  Google Scholar 

  • Sinha, Y., Silove, N., Wheeler, D., & Williams, K. (2004). Auditory integration training and other sound therapies for autism spectrum disorders. The Cochrane Database of Systematic Reviews, 1, CD003681, pub2.

    Google Scholar 

  • Sokolski, K. N. (2004). Selective serotonin reuptake inhibitor-related extrapyramidal symptoms in autistic children: a case series. Journal of Child and Adolescent Psychopharmacology, 14, 143–147.

    PubMed  Google Scholar 

  • Stachnik, J. M., & Nunn-Thompson, C. (2007). Use of atypical antipsychotics in the treatment of autistic disorder. The Annals of Pharmacotherapy, 41, 626–634.

    PubMed  Google Scholar 

  • Steingard, R. J., Zimnitzky, B., DeMaso, D. R., Bauman, M. L., & Bucci, J. P. (1997). Sertraline treatment of transition-associated anxiety and agitation in children with autistic disorder. Journal of Child and Adolescent Psychopharmacology, 7, 9–15.

    PubMed  Google Scholar 

  • Sweeney, P. P., Forness, S. R., & Levitt, J. G. (1998). An overview of medications commonly used to treat behavioral disorders associated with autism, Tourette syndrome, and pervasive developmental disorders. Focus on Autism and other Developmental Disabilities, 13, 144–150.

    Google Scholar 

  • Symes, M. D., Remington, B., Brown, T., & Hastings, R. P. (2006). Early intensive behavioral intervention for children with autism: Therapists’ perspectives on achieving procedural fidelity. Research in Developmental Disabilities, 27, 30–42.

    PubMed  Google Scholar 

  • Tager-Flusberg, H. (1996). Current theory and research on language and communication in autism. Journal of Autism and Developmental Disorders, 26, 169–172.

    PubMed  Google Scholar 

  • Tager-Flusberg, H., Joseph, R., & Folstein, S. (2001). Current directions in research on autism. Mental Retardation and Developmental Disabilities Research Reviews, 7, 21–29.

    PubMed  Google Scholar 

  • Towbin, K. E. (2003). Strategies for pharmacologic treatment of high functioning autism and Asperger syndrome. Child and Adolescent Psychiatric Clinics of North America, 12, 23–45.

    PubMed  Google Scholar 

  • Tsai, L. Y. (1996). Brief report: Comorbid psychiatric disorders of autistic disorder. Journal of Autism and Developmental Disorders, 26, 159–163.

    PubMed  Google Scholar 

  • Tsai, L. Y. (1999). Psychopharmacology in autism. Psychosomatic Medicine, 61, 651–665.

    PubMed  Google Scholar 

  • Tsai, S. J. (2006). Lithium and antidepressants: Potential agents for the treatment of Rett syndrome. Medical Hypotheses, 67, 626–629.

    PubMed  Google Scholar 

  • Van Lang, N. D. J., Bouma, A., Sytema, S., Kraijer, D. W., & Minderra, R. B. (2006). A comparison of central coherence skills between adolescents with an intellectual disability with and without comorbid autism spectrum disorder. Research in Developmental Disabilities, 27, 217–226.

    PubMed  Google Scholar 

  • Whittingham, K., Sofronoff, K., & Sheffield, J. K. (2006). Stepping stones triple P: A pilot study to evaluate acceptability of the program by parents of a child diagnosed with an autism spectrum disorder. Research in Developmental Disabilities, 27, 364–380.

    PubMed  Google Scholar 

  • Zachor, D. A., Roberts, A. W., Hodgens, J. B., Isaacs, J. S., & Merrick, J. (2006). Effects of long-term psychostimulant medication on growth of children with ADHD. Research in Developmental Disabilities, 27, 162–174.

    PubMed  Google Scholar 

  • Zuddas, A., Di Martino, A., Muglia, P., & Cianchetti, C. (2000). Long-term risperidone for pervasive developmental disorder: Efficacy, tolerability, and discontinuation. Journal of Child and Adolescent Psychopharmacology, 10, 79–90.

    PubMed  Google Scholar 

  • Zuddas, A., Ledda, M. G., Fratta, A., Muglia, P., & Cianchetti, C. (1996). Clinical effects of clozapine on autistic disorder. American Journal of Psychiatry, 153, 738.

    PubMed  Google Scholar 

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Matson, J.L., Dempsey, T. Autism Spectrum Disorders: Pharmacotherapy for Challenging Behaviors. J Dev Phys Disabil 20, 175–191 (2008). https://doi.org/10.1007/s10882-007-9088-y

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