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Hematologic Manifestations of Deficiency of Adenosine Deaminase 2 (DADA2) and Response to Tumor Necrosis Factor Inhibition in DADA2-Associated Bone Marrow Failure

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Acknowledgements

The authors would like to thank Dr. Michael Hershfield at the Duke University School of Medicine Department of Biochemistry for his assistance in performing plasma ADA2 analysis.

Author information

Authors and Affiliations

  1. Pediatrics and Communicable Diseases, Pediatric Hematology/Oncology, University of Michigan, 1500 E. Medical Center Drive, D4202 Medical Professional Building, Ann Arbor, MI, 48109, USA

    Thomas F. Michniacki, Mark T. Vander Lugt & Kelly J. Walkovich

  2. Pediatrics – Genetics, University of Michigan, Ann Arbor, MI, USA

    Mark Hannibal

  3. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

    Charles W. Ross

  4. Department of Pharmacy, University of Michigan, Ann Arbor, MI, USA

    David G. Frame

  5. Pediatric Hematology/Oncology, Oregon Health Sciences University, Portland, OR, USA

    Adam S. DuVall

  6. Department of Internal Medicine, Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA

    Rami Khoriaty

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  1. Thomas F. Michniacki
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  2. Mark Hannibal
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Contributions

Dr. Michniacki drafted the manuscript with assistance from Dr. Walkovich. Drs. Hannibal, Khoriaty, Ross, Frame, DuVall, and Vander Lugt assisted in reviewing and editing the manuscript. Dr. Ross additionally provided pathology images with marrow biopsy review for patient 1 and pathology report consultation for patients 1 and 2.

Corresponding author

Correspondence to Thomas F. Michniacki.

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The authors declare that they have no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Michniacki, T.F., Hannibal, M., Ross, C.W. et al. Hematologic Manifestations of Deficiency of Adenosine Deaminase 2 (DADA2) and Response to Tumor Necrosis Factor Inhibition in DADA2-Associated Bone Marrow Failure. J Clin Immunol 38, 166–173 (2018). https://doi.org/10.1007/s10875-018-0480-4

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  • DOI: https://doi.org/10.1007/s10875-018-0480-4

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