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The Advantage of Specific Intravenous Immunoglobulin (sIVIG) on Regular IVIG: Experience of the Last Decade

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Abstract

During the last decade it has been shown that some components of intravenous immunoglobulin (IVIG) are responsible for their broadly therapeutic application. Currently, such specific subfractions are defined as specific IVIG (sIVIG) and are affinity-purified from commercial IVIGs that target specific antigens/antibodies related to a specific autoimmune disease. A remarkable example of the therapeutic potential of sIVIG is the proven enhanced anti-inflammatory potency of sialylated and recombinant sialylated IVIG obtained from total IVIG. In other experimental models, it has also been demonstrated that sIVIG work in many other contrivances, such as revealing anti-idiotypic networks blocking pathogenic antibodies ameliorating disease activity. sIVIG has also been shown to exert its action by modulating specific receptors expressed on immune cells in both inflammatory and autoimmune diseases. Indeed, sIVIG has emerged as a novel approach to treat different immune-mediated conditions in a more accurate antigen-specific manner. Herein we review experimental evidence supporting sIVIG-efficacy in treating autoimmune diseases and inflammation.

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Acknowledgments

The study was supported by E-rare grant no. 4790 given by the EU/Israeli Ministry of Health and Laboratoire Français des Biotechnologies, LFB Tegeline, France.

This work was performed in partial fulfillment of the requirements for the PhD thesis of Nina Svetlicky, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center affiliated with Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Nina Svetlicky, Oscar-Danilo Ortega-Hernandez, Arie Altman, Martine Szyper Kravitz & Miri Blank

  2. Department of Internal Medicine, Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Paris, France

    Luc Mouthon & Loic Guillevin

  3. Department of Immunology, University of Rostock, Rostock, Germany

    Hans-Jurgen Thiesen

  4. Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine Tel-Aviv University, Tel-Aviv, Israel

    Yehuda Shoenfeld

  5. Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel

    Yehuda Shoenfeld

  6. Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, 52621, Israel

    Yehuda Shoenfeld

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  1. Nina Svetlicky
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  2. Oscar-Danilo Ortega-Hernandez
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  9. Yehuda Shoenfeld
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Correspondence to Yehuda Shoenfeld.

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Svetlicky, N., Ortega-Hernandez, OD., Mouthon, L. et al. The Advantage of Specific Intravenous Immunoglobulin (sIVIG) on Regular IVIG: Experience of the Last Decade. J Clin Immunol 33 (Suppl 1), 27–32 (2013). https://doi.org/10.1007/s10875-012-9842-5

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  • DOI: https://doi.org/10.1007/s10875-012-9842-5

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