Abstract
Biologically derived hydroxyapatite from calcinated (at 850 °C) bovine bones (BHA) was doped with 5 wt% and 10 wt% of SiO2, MgO, Al2O3 and ZrO2 (stabilized with 8% Y2O3). The aim was to improve the sintering ability and the mechanical properties (compression strength and hardness) of the resultant BHA-composites. Cylindrical samples were sintered at several temperatures between 1,000 and 1,300 °C for 4 h in air. The experimental results showed that sintering generally occurs at 1,200 °C. The BHA–MgO composites showed the best sintering performance. In the BHA–SiO2 composites, extended formation of glassy phase occurred at 1,300 °C, resulting in structural degradation of the resultant samples. No sound reinforcement was achieved in the case of doping with Al2O3 and zirconia probably due to the big gap between the optimum sintering temperatures of BHA and these two oxides.
Similar content being viewed by others
References
B. BEN-NISSAN, A. MILEV and R. VAGO, Biomaterials 25 (2004) 4971
L. S. OZYEGIN, F. N. OKTAR, G. GOLLER, E. S. KAYALI and T. YAZICI, Mater. Lett. 58 (2004) 2605
J. H. G. ROCHA, A. F. LEMOS, S. AGATHOPOULOS, P. VALEIRO, S. KANNAN, F. N. OKTAR and J. M. F. FERREIRA, Bone 37 (2005) 850
F. N. OKTAR, Mater. Lett. 60 (2006) 2207
S. AGATHOPOULOS, D. U. TULYAGANOV, P. A. A. P. MARQUES, M. C. FERRO, M. H. V. FERNANDES and R. N. CORREIA, Biomaterials 24 (2003) 1317
http://www.innvista.com/default.htm, Minerals
J. W. REID, L. TUCK, M. SAYER, K. FARGO and J. A. HENDRY, Biomaterials 27 (2006) 2916
S. K. KIM, J. H. LEE, Y. T. KIM, D. H. RIU, S. J. JUNG, Y. J. LEE, S. C. CHUNG and Y. H. KIM, Biomaterials 24 (2003) 1389
E. BERTONI, A. BIGI, G. COJAZZI, M. GANDOLFI, S. PANZAVOLTA and N. ROVERI, J. Inorg. Biochem. 72 (1998) 29
S. NI, L. CHOU and J. CHANG, Ceram. Int. 33 (2007) 83
S. AGATHOPOULOS, D. U. TULYAGANOV, J. M. G. VENTURA, S. KANNAN, M. A. KARAKASSIDES and J. M. F. FERREIRA, Biomaterials 27 (2006) 1832
W. CHENGTIE, C. JIANG, W. JUNJING, N. SIYU and Z. WANYIN, Biomaterials 26 (2005) 2925
A. GOEL, D. U. TULYAGANOV, S. AGATHOPOULOS, M. J.RİBEİRO and J. M. F.FERREİRA, Ceram. Int. (2007) doi:10.1016/j.ceramint.2006.05.012
H.-W. KIM, Y.-H. KOH, S.-B. SEO and H.-E. KIM, Mater. Sci. Eng. C 23 (2003) 515
A. CHIBA, S. KIMURA, R. RAGHUKANDAN and Y. MORIZONO, Mater. Sci. Eng. A 350 (2003) 179
F. N. OKTAR, Y. GENC, G. GOLLER, S. AGATHOPOULOS, D. U. TULYAGANOV, J. M. F. FERREIRA, E. S. KAYALI and S. SALMAN Key Eng. Mater. 284–286 (2005) 709
K. YOSHIDA, K. HASHIMOTO, Y. TODA, S. UDAGAWA and T. KANAZAWA, J. Eur. Ceram. Soc. 26 (2006) 515
S. AGATHOPOULOS, P. NIKOLOPOULOS, A. SALOMONI, A. TUCCI and I. STAMENKOVIC, J. Mater. Sci. Mater. Med. 7 (1996) 629
F. N. OKTAR, K. KESENCI and E. PISKIN, Int. J. Artif. Cells Blood Sub. Immob. Biotech. 27 (1999) 367
W. SUCHANEK, M. YASHIMA, M. KAKIHANA and M. YOSHIMURA, Biomaterials 18 (1997) 923
Y. GENC, F. N. OKTAR, E. Z. ERKMEN, G. GOLLER, D. TOYKAN and H. HAYBAT, Key Eng. Mater. 264–268 (2004) 1961
H. GOKBAYRAK, Production of hydroxyapatite ceramics, M.S. Thesis. (Bogazici University, 1996)
S. GOREN, H. GOKBAYRAK and S. ALTINTAS, Key Eng. Mater. 264–268 (2004) 1949
G. GOLLER, F. N. OKTAR, S. AGATHOPOULOS, D. U. TULYAGANOV, J. M. F. FERREIRA, E. S. KAYALI and I. PEKER, J. Sol-Gel Sci. Techn. 37 (2006) 111
F. N. OKTAR, M. R. DEMIRER, O. GUNDUZ, Y. GENC, S. AGATHOPOULOS, I. PEKER, L. S. OZYEGIN and S. SALMAN, Key Eng. Mater. 309–311 (2006) 49
S. AGATHOPOULOS, M. C. FERRO, J. Y. XU, J. M. OLIVEIRA, P. A. A. P. MARQUES, R. N. CORREIA and M. H. V. FERNANDES, Key Eng. Mater. 240–242 (2003) 217
M. KNEPPER, S. MORICCA and B. K. MILTHORPE, Biomaterials 18 (1997)1523
Y.-M. KONG, C.-J. BAE, S.-H. LEE, H.-W. KIM and H.-E. KIM, Biomaterials 26 (2005) 509
M. S. KHALIL, H. H. BEHERI and W. I. ABDEL FATTAH, Ceram. Int. 28 (2002) 451
A. RAPACZ-KMITA, A. lOSARCZYK, Z. PASZKIEWICZ and C. PALUSZKIEWICZ, J. Mol. Struct. 704 (2004) 333
Acknowledgements
This study was carried out with the financial support of the Turkish Republic Government Planning Organization in the framework of the Project “Manufacturing and Characterization of Electro-Conductive Bioceramics” with project number 2003 K120810. S. Agathopoulos gratefully acknowledges his financial support through the Project ENTER 04EP26 of the European Union and the Greek Secretariat of Research and Technology. SEM pictures were taken under supervision of Associate Professor Ahmet Capoglu from Gebze Institute of Technology. The authors thank to Associate Professor Dr. G. Goller from Istanbul Technical University for using the microhardness apparatus.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Oktar, F.N., Agathopoulos, S., Ozyegin, L.S. et al. Mechanical properties of bovine hydroxyapatite (BHA) composites doped with SiO2, MgO, Al2O3, and ZrO2 . J Mater Sci: Mater Med 18, 2137–2143 (2007). https://doi.org/10.1007/s10856-007-3200-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10856-007-3200-9