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Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro

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Abstract

Bioactive glasses (BAGs) of different compositions have been studied for decades for clinical use and they have found many dental and orthopaedic applications. Particulate BAGs have also been shown to have antibacterial properties. This large-scale study shows that two bioactive glass powders (S53P4 and 13–93) and a sol–gel derived material (CaPSiO II) have an antibacterial effect on 17 clinically important anaerobic bacterial species. All the materials tested demonstrated growth inhibition, although the concentration and time needed for the effect varied depending on the BAG. Glass S53P4 had a strong growth-inhibitory effect on all pathogens tested. Glass 13–93 and sol–gel derived material CaPSiO II showed moderate antibacterial properties.

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Acknowledgement

This study was supported by the Finnish Funding Agency for Technology and Innovation (TEKES).

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Author notes

  1. Minna Vaahtio & Timo Peltola

    Present address: Vivoxid Ltd., Tykistökatu 4 A, Turku, 20520, Finland

Authors and Affiliations

  1. Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, Turku, 20520, Finland

    Outi Leppäranta, Matti K. Viljanen & Erkki Eerola

  2. Finnish Food Safety Authority Evira, Mustialankatu 3, Helsinki, 00790, Finland

    Outi Leppäranta

  3. Turku Biomaterials Centre, University of Turku, Itäinen Pitkäkatu 4 B, Turku, 20520, Finland

    Minna Vaahtio, Timo Peltola, Heimo Ylänen & Jukka I. Salonen

  4. Process Chemistry Centre, Åbo Akademi University, Piispankatu 8, Turku, 20500, Finland

    Di Zhang, Leena Hupa, Mikko Hupa & Heimo Ylänen

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  1. Outi Leppäranta
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  2. Minna Vaahtio
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Correspondence to Outi Leppäranta.

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Leppäranta, O., Vaahtio, M., Peltola, T. et al. Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro. J Mater Sci: Mater Med 19, 547–551 (2008). https://doi.org/10.1007/s10856-007-3018-5

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  • DOI: https://doi.org/10.1007/s10856-007-3018-5

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