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Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients

  • Assisted Reproduction
  • Published:
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Abstract

Purpose

This prospective study was designed to investigate whether anti-Müllerian hormone (AMH) levels at basal and ovulation triggering day are associated with ovarian response and pregnancy outcome for in vitro fertilization (IVF).

Method

60 infertility women undergoing IVF were prospectively studied. On day 3 of the menstrual cycle (D3), measurements of AMH, inhibin B, FSH, LH, and E2 and ultrasound evaluation of antral follicle count (AFC) were performed. Serum AMH and inhibin B levels were remeasured on the day of hCG administration (DhCG). The outcome measures were the number of retrieved oocytes and clinical pregnancy.

Results

Number of retrieved oocytes was statistically significant and correlated with D3 AMH, AFC, DhCG AMH, DhCG inhibin B, FSH, and age (r = 0.885, 0.874, 0.742, 0.732, −0.521, −0.385, respectively). Statistically significant differences were found between pregnant and non-pregnant women regarding D3 AMH and AFC. Multiple regression analysis for prediction of pregnancy showed D3 AMH to be a good predictor of clinical pregnancy.

Conclusion

AMH correlates better than age, FSH, and inhibin B with the number of retrieved oocytes. Serum basal AMH may offer a better prognostic value for clinical pregnancy than other currently available markers of IVF outcome in our preliminary study.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan, Republic of China

    Cheng-Hsuan Wu, Yu-Ching Chen, Hsin-Hung Wu, Jyuer-Ger Yang & Horng-Der Tsai

  2. Epidemiology and Biostatistics Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan, Republic of China

    Yu-Jun Chang

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  1. Cheng-Hsuan Wu
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  2. Yu-Ching Chen
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  3. Hsin-Hung Wu
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Correspondence to Horng-Der Tsai.

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Capsule

Serum basal AMH correlates better than age, FSH, and inhibin B with the number of retrieved oocytes and may offer a better prognostic value for clinical pregnancy in IVF cycles.

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Wu, CH., Chen, YC., Wu, HH. et al. Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients. J Assist Reprod Genet 26, 383–389 (2009). https://doi.org/10.1007/s10815-009-9332-8

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  • DOI: https://doi.org/10.1007/s10815-009-9332-8

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