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Brief Report: An Autistic Spectrum Subtype Revealed Through Familial Psychopathology Coupled with Cognition in ASD

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Abstract

This study identified a possible autistic spectrum subtype expressed through family psychopathology coupled with autistic probands’ cognitive functioning (i.e., an endophenotypic profile). Participants included 24 children with Autism Spectrum Disorder (ASD) and 49 children with Learning Disorder (LD). There were significantly higher rates of Mood and Anxiety Disorder in first degree maternal relatives and of LD and Attention-Deficit Hyperactivity Disorder in first degree paternal relatives of ASD probands. Significantly higher visuospatial functioning was noted in all ASD probands for which there were higher rates of Mood Disorder on the maternal side suggesting a possible marker for an ASD subtype and indicating that maternal psychopathology may have a neuroprotective effect on visuospatial functioning.

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References

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.-text revised). Washington, DC: Author.

  • Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., & Pearlson, G. D. (1999). MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145–2150.

    PubMed  Google Scholar 

  • Baron-Cohen, S., & Hammer, J. (1997). Parents of children with asperger syndrome: What is the cognitive phenotype? Journal of Cognitive Neuroscience, 9, 548–555.

    Article  Google Scholar 

  • Barry, J. G., Yasin, I., & Bishop, D. V. (2007). Heritable risk factors associated with language Impairments. Genes, Brain, and Behavior, 6, 66–76.

    Article  PubMed  Google Scholar 

  • Briskman, J., Happe, F., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “Central Coherence” in parents and siblings of children with Autism: II. Real-life skills and preferences. Journal of Child Psychology and Psychiatry, 42, 309–316.

    Article  PubMed  Google Scholar 

  • Carey, J., & McMahon, W. (1999). Neurobehavioral disorders and medical genetics. In S. Goldstein & C. R. Reynolds (Eds.), Handbook of neurodevelopmental and genetic disorders in children (pp. 38–60). New York, NY: The Guilford Press.

    Google Scholar 

  • Caron, M. J., Mottron, L., Berthiaume, C., & Dawson, M. (2006). Cognitive mechanisms, Specificity and neural underpinnings of visuospatial peaks in autism. Brain, 129, 1789–1802.

    Article  PubMed  Google Scholar 

  • Caron, M. J., Mottron, L., Rainville, C., & Chouinard, S. (2004). Do high functioning persons with autism present superior spatial abilities? Neuropsychologia, 42, 467–481.

    Article  PubMed  Google Scholar 

  • Cohen, I. L., & Tsiouris, J. A. (2006). Maternal recurrent mood disorder in high functioning autism. Journal of Autism and Developmental Disorders, 36, 1077–1088.

    Article  PubMed  Google Scholar 

  • Courchesne, E., Townsend, J., Akshoomoff, N., et al. (1994). Impairments in shifting attention in autistic and cerebellar patients. Behavioral Neuroscience, 108, 848–865.

    Article  PubMed  Google Scholar 

  • Courchesne, E., Townsend, J., & Saitoh, O. (1994). The brain in infantile autism: Posterior fossa structures are abnormal. Neurology, 44, 214–223.

    PubMed  Google Scholar 

  • Courchesne, E., Press, G. A., & Yeung-Courchesne, R. (1993). Parietal lobe abnormalities detected with MRI in patients with infantile autism. American Journal of Radiology, 160, 387–393.

    Google Scholar 

  • DeLong, R. (2004). Autism and familial major mood disorder: Are they related? Journal of Neuropsychiatry and Clinical Neurosciences, 16, 199–213.

    PubMed  Google Scholar 

  • Edgin J. O., & Pennington, B. F. (2005). Spatial cognition in autistic spectrum disorders: Superior, impaired, or just intact. Journal of Autism and Developmental Disorders, 35, 729–745.

    Article  PubMed  Google Scholar 

  • Gayan, J., Smith, S. D., Cherny, S. S., Cardon, L. R., Fulker, D. W., Brower, A. M., Olson, R. K., Pennington, B. F., & DeFries, J. C. (1999). Quantitative-trait locus for specific language and reading deficits on chromosome 6p. American Journal of Human Genetics, 64, 157–64.

    Article  PubMed  Google Scholar 

  • Glahn, D. C., Thompson, P. M., & Blanghero, J. (2007). Neuroimaging phenotypes: Strategies for finding genes influencing brain structure and function. Human Brain Mapping, 28, 488–501.

    Article  PubMed  Google Scholar 

  • Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645.

    Article  PubMed  Google Scholar 

  • Happe, F., Briskman, J., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “Central Coherence” in parents and siblings of children with autism: I. Experimental Tests. Journal of Child Psychology and Psychiatry, 42, 299–307.

    Article  PubMed  Google Scholar 

  • Hughes, C., Leboyer, M., & Bouvard, M. (1997). Executive functioning of children with autism. Psychological Medicine, 27, 209–220.

    Article  PubMed  Google Scholar 

  • Hughes, C., Plumet, M., & Leboyer, M. (1999). Towards a cognitive phenotype for autism: Increased prevalence of executive dysfunction and superior spatial span amongst sibling of children with autism. Journal of Child Psychology and Psychiatry. 40, 705–718.

    Article  PubMed  Google Scholar 

  • Klin, A., Volkmar, F. R., Sparrow, S. S., Cicchetti, D. V., & Rourke, B. P. (1995). Validity and Neuropsychological characterization of Asperger syndrome: convergence with nonverbal Learning disabilities syndrome. Journal of Child Psychology and Psychiatry, 36, 1127–1140.

    Article  PubMed  Google Scholar 

  • Koczat, D., Rogers, S., Pennington, B., & Ross, R. (2002). Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands. Journal of Autism and Developmental Disorders, 32, 513–518.

    Article  PubMed  Google Scholar 

  • Korkman, M., Kirk, U., & Kemp, S. (1998). NEPSY: A neurodevelopmental neuropsychological assessment. The Psychological Corporation, San Antonio, TX.

  • Lainhart, J. (1999). Psychiatric problems in individuals with autism, their parents and siblings. International Review of Psychiatry, 11, 278–298.

    Article  Google Scholar 

  • Lauritsen, M., Pedersen, C., & Mortensen, P. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry, 46, 963–971.

    Article  PubMed  Google Scholar 

  • Lord C., Rutter M., & LeCouteur A (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.

    Article  PubMed  Google Scholar 

  • McDougle, C. J., Erickson, C. A., Stigler, K. A., & Posey, D. J. (2005). Neurochemistry in the pathophysiology of autism. Journal of Clinical Psychiatry, 66(Suppl 10), 9–18.

    PubMed  Google Scholar 

  • Micali, N., Chakrabarti, S., & Frombonne, E. (2004). The broad autism phenotype: Findings from an epidemiological survey. Autism, 1, 21–37.

    Article  Google Scholar 

  • Autism, Developmental Disabilities Monitoring Network Surveillance Year. 2000 Principal Investigators; Centers for Disease Control and Prevention. (2007). Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring, six sites, United States, 2000. MMWR Surveillance Summary, 56, 1–11.

    Google Scholar 

  • Murphy, M., Bolton, P., Pickles, A., Fombonne, E., Piven, J., Rutter, M. (2000). Personality traits of the relatives of autistic probands. Psychological Medicine, 30, 1411–1424.

    Article  PubMed  Google Scholar 

  • Ozonoff, S., Coon H., Dawson, G., Joseph, R., Klin, A., & McMahon, W., et al. (2004). Performance on CANTAB subtests sensitive to frontal lobe function in people with autistic disorder: Evidence from the CPEA Network. Journal of Autism and Developmental Disorders, 34, 139–150.

    Article  PubMed  Google Scholar 

  • Ozonoff, S. & Strayer, D. L. (1997). Inhibitory function in nonretarded children with autism. Journal of Autism and Developmental Disorders, 27, 59–77.

    Article  PubMed  Google Scholar 

  • Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from a family study of multiple-incidence autism families. American Journal of Psychiatry, 156, 557–563.

    PubMed  Google Scholar 

  • Schopler, E., Reichler, R. J., & Renner, B. R. (1988). The childhood autism rating scale (CARS). Los Angeles: Western Psychological Services.

  • Shah, A., & Frith, U. (1993). Do autistic individuals show superior performance on the Block Design task? Journal of Child Psychology and Psychiatry, 24, 612–620.

    Google Scholar 

  • Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Castillo, E. M., & Papanicolaou, A. C., 2000). Cerebral mechanisms involved in word reading in dyslexic children: A magnetic source imaging study. Cerebral Cortex, 10, 809–816.

    Article  PubMed  Google Scholar 

  • Wheelwright, S., & Baron-Cohen, S. (2001). The link between autism and skills such as engineering, math, physics, and computing. Autism, 5, 223–227.

    Article  PubMed  Google Scholar 

  • Wong, D., Maybery, M., Bishop, D. V., Maley, A., & Hallmayer, J (2006). Profiles of executive function in parents and siblings of individuals with autism spectrum disorders. Genes, Brain, and Behavior, 5, 561–576.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, Eastern Michigan University, 537F Mark-Jefferson, Ypsilanti, MI, 48197, USA

    Renée Lajiness-O’Neill & Philip Menard

  2. Department of Behavioral Services, Division of Neuropsychology, Henry Ford Health System, Detroit, MI, USA

    Renée Lajiness-O’Neill

Authors
  1. Renée Lajiness-O’Neill
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  2. Philip Menard
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Correspondence to Renée Lajiness-O’Neill.

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Lajiness-O’Neill, R., Menard, P. Brief Report: An Autistic Spectrum Subtype Revealed Through Familial Psychopathology Coupled with Cognition in ASD. J Autism Dev Disord 38, 982–987 (2008). https://doi.org/10.1007/s10803-007-0464-3

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  • DOI: https://doi.org/10.1007/s10803-007-0464-3

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