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The effects of collagen cross-linking on corneal density: a comparison between accelerated and conventional methods

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Abstract

Purpose

To compare the corneal density before and after accelerated versus conventional corneal cross-linking (CXL).

Methods

Pentacam densitometry and corneal mapping were performed before and 6 months following the randomly assigned intervention. Corneal density was measured over different zones and layers of the cornea by two independent ophthalmologists. Total corneal density was calculated. The patients were followed up for the occurrence of procedure-related and unrelated complication 1 week, 1 month and a final visit around 6 months (180 ± 10 days) after the procedure, during which the corneal density was remeasured and recorded.

Results

Twenty-three patients were enrolled. There was a significant increase in corneal density over the anterior layer (P < 0.001) and middle corneal layer (P = 0.035). Additionally, the corneal density significantly increased in 0–2 and 2–6 mm zones (P < 0.001), as well as total density (P = 0.002) following corneal CXL. Although there was no significant difference in the corneal density between the two CXL groups, the increase in corneal density was only significant in group A for the 6–10 mm zone and the posterior corneal layer.

Conclusion

Both the conventional and accelerated CXL methods increase the overall corneal density with exception of posterior central corneal layer and the 6–10 mm zone, which is only increased in the accelerated method.

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Authors and Affiliations

  1. Nikookari Hospital (Eye Center), Tabriz University of Medical Sciences, Tabriz, Iran

    Ali Mahdavi Fard, Rana Daei Sorkhabi & Mojtaba Khazaei

  2. Department of Anesthesiology, State University of New York at Buffalo, 77 Goodell Street, Suite 550, Buffalo, NY, 14203, USA

    Nader D. Nader

Authors
  1. Ali Mahdavi Fard
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  2. Rana Daei Sorkhabi
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  3. Mojtaba Khazaei
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  4. Nader D. Nader
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Correspondence to Nader D. Nader.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Mahdavi Fard, A., Daei Sorkhabi, R., Khazaei, M. et al. The effects of collagen cross-linking on corneal density: a comparison between accelerated and conventional methods. Int Ophthalmol 39, 1559–1566 (2019). https://doi.org/10.1007/s10792-018-0961-8

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  • DOI: https://doi.org/10.1007/s10792-018-0961-8

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