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Increased red cell distribution width levels in children with seasonal allergic conjunctivitis

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Abstract

Purpose

Seasonal allergic conjunctivitis (SAC) is an inflammatory disease of the conjunctiva. Red cell distribution width (RDW) is a widely accepted inflammatory marker. We aimed to investigate whether RDW level is associated with the development of SAC in pediatric population.

Methods

The present study consisted of 90 subjects (45 children with SAC and 45 age- and sex-matched healthy children). The demographic findings, complete blood count parameters including RDW and laboratory parameters, were evaluated.

Results

The mean RDW levels were significantly higher in children with SAC compared to the control group (14.02 ± 0.82 vs. 13.26 ± 0.64%, respectively, p < 0.001). In receiver operating characteristic analysis, the area under the curve for RDW for predicting SAC was 0.786, and a RDW value of 13.45 or higher predicted SAC with a sensitivity of 75.6% and specificity of 65%.

Conclusion

Our study suggests that elevated RDW levels are significantly associated with SAC in pediatric population, which may imply a possible role of increased inflammatory status and oxidative stress in the pathogenesis of SAC.

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Authors and Affiliations

  1. Department of Ophthalmology, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey

    Bengi Ece Kurtul, Emrah Utku Kabatas & Pinar Altiaylik Ozer

  2. Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey

    Songul Deniz Boybeyi & Ayla Akca Caglar

Authors
  1. Bengi Ece Kurtul
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  2. Emrah Utku Kabatas
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  3. Songul Deniz Boybeyi
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  4. Ayla Akca Caglar
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  5. Pinar Altiaylik Ozer
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Correspondence to Bengi Ece Kurtul.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Kurtul, B.E., Kabatas, E.U., Boybeyi, S.D. et al. Increased red cell distribution width levels in children with seasonal allergic conjunctivitis. Int Ophthalmol 38, 1079–1084 (2018). https://doi.org/10.1007/s10792-017-0563-x

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  • DOI: https://doi.org/10.1007/s10792-017-0563-x

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