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FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation

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Abstract

Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1β expression in THP-1 cells. Furthermore, besides the NF-κB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.

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Funding

This study was funded by the “Young Talents” Project of Northeast Agricultural University (grant number 16QC27) and Natural Science Foundation of Heilongjiang Province of China (grant number C2017023).

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Authors and Affiliations

  1. Northeast Agricultural University, School of Life Science, Harbin, Heilongjiang Province, China

    Jun-yan Li, Nan Wang, Mir Hassan Khoso, Cheng-bin Shen, Meng-ze Guo, Xin-xin Pang & De-shan Li

  2. Life Science and Biotechnique Research Center, A Division of Northeast Agricultural University, Harbin, Heilongjiang Province, 150030, China

    Wen-fei Wang

Authors
  1. Jun-yan Li
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  2. Nan Wang
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  3. Mir Hassan Khoso
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  4. Cheng-bin Shen
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  5. Meng-ze Guo
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  6. Xin-xin Pang
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  7. De-shan Li
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  8. Wen-fei Wang
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Correspondence to De-shan Li or Wen-fei Wang.

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The study was approved by the Ethics Committee of Northeast Agricultural University.

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Li, Jy., Wang, N., Khoso, M.H. et al. FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation. Inflammation 41, 751–759 (2018). https://doi.org/10.1007/s10753-018-0729-3

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  • DOI: https://doi.org/10.1007/s10753-018-0729-3

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