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Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea

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Abstract

Background

Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea.

Methods

We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated.

Results

The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031).

Conclusion

CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.

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    Authors and Affiliations

    1. Department of Internal Medicine and Institute of Gastroenerology, Yonsei University College of Medicine, 50-1 Yonseiro, Seodaemun-gu, Seoul, 120-752, Korea

      Sook Hee Chung & Jae Hee Cheon

    2. Department of Internal Medicine and Institute of Gastroenerology, Ajou University College of Medicine, Suwon, Korea

      Sook Hee Chung

    3. Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Korea

      Sang Un Park, Eun Ran Kim & Dong Kyung Chang

    4. Departments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

      Jeong-Sik Byeon & Byong Duk Ye

    5. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

      Bora Keum

    6. Departments of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea

      Ki-Nam Shim & Sung-Ae Jung

    7. Department of Internal Medicine, Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, Korea

      Jin-Oh Kim & Seong Ran Jeon

    8. Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea

      Hyun Joo Song

    9. Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea

      Jeong Seop Moon

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    1. Sook Hee Chung
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    2. Sang Un Park
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    Corresponding authors

    Correspondence to Jae Hee Cheon or Dong Kyung Chang.

    Additional information

    Sook Hee Chung and Sang Un Park have contributed equally to this work.

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    Chung, S.H., Park, S.U., Cheon, J.H. et al. Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea. Dig Dis Sci 60, 2740–2745 (2015). https://doi.org/10.1007/s10620-015-3595-y

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    • DOI: https://doi.org/10.1007/s10620-015-3595-y

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