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Limonoids from the Seeds of Chisocheton macrophyllus

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Chemistry of Natural Compounds Aims and scope

A new limonoid compound, dysobinol (1), along with three known limonoid compounds, 7α-hydroxyneotricilenone (2), dysobinin (3), and nimonol (4), was isolated from the seeds of Chisocheton macrophyllus (Meliaceae). Their structures were established by spectroscopic techniques such as UV, IR, MS, 1D, and 2D NMR. Compounds 1–4 showed cytotoxic activity against P-388 murine leukemia cells with IC50 values of 49.7, 79.4, 19.5, and 64.5 μg/mL, respectively.

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Acknowledgment

This work was supported partially by the Directorate General of Higher Education, Ministry of Education and Culture, Indonesia (Hibah Andalan, Unpad, 2011–2013, DH). We thank Mr. Ahmad Darmawan and Mrs. Sofa Fajriah in the Research Center for Chemistry, Indonesian Science Institute, Serpong, Indonesia for NMR measurements. We are grateful to Prof. Yoshihito Shiono at the Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Japan for HR-ESI-TOFMS measurements.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, 45262, Jatinangor, Indonesia

    Nurlelasari, Dewa Gede Katja, Desi Harneti & Unang Supratman

  2. Faculty of Pharmacy, Padjadjaran University, 45363, Jatinangor, Indonesia

    Moelyono Moekti Wardayo

  3. Department of Chemistry, Faculty of Science, University of Malaya, 59100, Kuala Lumpur, Malaysia

    Khalijah Awang

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  1. Nurlelasari
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  2. Dewa Gede Katja
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 71–74.

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Nurlelasari, Katja, D.G., Harneti, D. et al. Limonoids from the Seeds of Chisocheton macrophyllus . Chem Nat Compd 53, 83–87 (2017). https://doi.org/10.1007/s10600-017-1916-4

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  • DOI: https://doi.org/10.1007/s10600-017-1916-4

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