Skip to main content
SpringerLink
Log in

Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate

  • Published:
Chemistry of Natural Compounds Aims and scope

The ester of l-menthol and γ-aminobutyric acid, (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-aminobutyrate hydrochloride was synthesized. Its anticonvulsant activity was studied in vivo by determining the minimum effective doses of pentylenetetrazole inducing clonic-tonic convulsions and tonic extension. Menthyl γ-aminobutyrate possessed prolonged anticonvulsant activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. V. Plemenkov, Introduction to the Chemistry of Natural Compounds [in Russian], Kazan′, 2001, 376 pp.

  2. D. D. McKemy, Mol. Pain, 16, 2 (2005).

    Google Scholar 

  3. R. Eccles, J. Pharm. Pharmacol., 46, 624 (1994).

    Article  Google Scholar 

  4. B. K. Lau, S. Karim, A. K. Goodchild, C. W. Vaughan, and G. M. Drew, Br. J. Pharmacol., 171, 2804 (2014).

    Google Scholar 

  5. V. V. Bagmetova, L. E. Borodkina, I. N. Tyurenkov, V. M. Berestovitskaya, and O. S. Vasil′eva, Fundam. Issled., 10, 467 (2011).

    Google Scholar 

  6. P. M. Dewang, V. P. Nikumbh, V. S. Tare, and P. P. Mahulikar, J. Sci. Ind. Res., 62, 990 (2003).

    CAS  Google Scholar 

  7. T. S. Raikova, G. V. Kalechits, E. N. Manukov, T. K. Vyalimyae, and S. A. Makhach, Chem. Nat. Compd., 17, 526 (1981).

    Article  Google Scholar 

  8. V. F. Pozdnev, Bioorg. Khim., 725 (1985).

  9. A. A. Gershkovich and V. K. Kibirev, Peptide Synthesis. Reagents and Methods [in Russian], Naukova Dumka, Kiev, 1987, 264 pp.

  10. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, Council of Europe, Strasbourg, 123, 51 (1986).

Download references

Author information

Authors and Affiliations

  1. I. I. Mechnikov Odessa National University, 2 Dvoryanskaya, Odessa, Ukraine, 65026

    M. V. Nesterkina & I. A. Kravchenko

  2. A. V. Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, 86 Lyustdorfskaya Rd., Odessa, Ukraine, 65080

    I. A. Kravchenko

Authors
  1. M. V. Nesterkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. A. Kravchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. V. Nesterkina.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2016, pp. 208–210.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nesterkina, M.V., Kravchenko, I.A. Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate. Chem Nat Compd 52, 237–239 (2016). https://doi.org/10.1007/s10600-016-1604-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-016-1604-9

Keywords

Search

Navigation