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Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview)

  • HETEROCYCLES IN FOCUS
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Chemistry of Heterocyclic Compounds Aims and scope

[1,2,4]Triazolo[1,5-a]pyrimidines are very interesting and trend class of fused heterocycles due to their valuable biological properties. Some [1,2,4]-triazolo[1,5-a]pyrimidines possess herbicidal activity,1 also they can act as antifungal,2 antitubercular,3 and antibacterial4 agents. Polycyclic systems containing [1,2,4]triazolo[1,5-a]-pyrimidine moiety are reported as antitumor,5 as corticotropin-releasing factor 1 receptor antagonists6 or calcium channel modulators;7 they can be used for treatment of Alzheimer's disease8 and insomnia.9 Complexes of triazolo-pyrimidines with Pt and Ru are highly active against parasites10 and can also be used in treating cancer.11

The synthetic ways for the preparation of [1,2,4]triazolo[1,5-a]-pyrimidines can be divided into two main groups: annulation of pyrimidine moiety to triazole ring and annulation of triazole fragment to pyrimidine ring. The Dimroth rearrangement of [1,2,4]triazolo[4,3-a]pyrimidines can also be used for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines. In this review article we have focused on synthetic approaches for the creation of [1,2,4]triazolo[1,5-a]pyrimidine system.

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  1. Faculty of Chemistry, Uzhhorod National University, 46 Pidhirna St., Uzhhorod, 88000, Ukraine

    Maksym Fizer & Mikhailo Slivka

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  1. Maksym Fizer
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  2. Mikhailo Slivka
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Correspondence to Mikhailo Slivka.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(3), 155–157

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Fizer, M., Slivka, M. Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview). Chem Heterocycl Comp 52, 155–157 (2016). https://doi.org/10.1007/s10593-016-1851-5

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  • DOI: https://doi.org/10.1007/s10593-016-1851-5

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