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Evaluation of the Functional Status Questionnaire in Heart Failure: A Sub-study of the Second Cardiac Insufficiency Bisoprolol Survival Study (CIBIS-II)

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Abstract

Aims

We evaluated a generic quality of life (QoL) Functional Status Questionnaire (FSQ), in patients with chronic heart failure (CHF). The FSQ assesses the 3 main dimensions of QoL: physical functioning, mental health and social role. It also includes 6 single item questions about: work status, frequency of social interactions, satisfaction with sexual relationships, days in bed, days with restricted activity and overall satisfaction with health status. The FSQ was compared to the Minnesota Living with Heart Failure questionnaire (MLwHF).

Methods and results

The FSQ was evaluated in a substudy (n = 340) of the second Cardiac Insufficiency Bisoprolol Survival study (CIBIS-II), a placebo-controlled mortality trial. 265 patients (75%) patients completed both questionnaires at 6 months of follow-up. Both questionnaires indicated substantially impaired QoL. The FSQ demonstrated high internal consistency (Cronbach’s α > 0.7 for all items except “social activity” = 0.66) and construct and concurrent validity. After 6 months, the only item on either questionnaire to show a difference between the placebo- and bisoprolol-treatment groups was the single item FSQ question about “days in bed” (p = 0.018 in favour of bisoprolol).

Conclusions

The FSQ performed well in this study, provided additional information to the MLwHF questionnaire and allowed interesting comparisons with other chronic medical conditions. The FSQ may be a useful general QoL instrument for studies in CHF.

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Authors and Affiliations

  1. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK

    Siobhan Gallanagh, Davide Castagno, Ben Wilson & John J. V. McMurray

  2. Cardiology Unit, Department of Internal Medicine, University of Turin, Turin, Italy

    Davide Castagno

  3. Department III of Internal Medicine, University of Cologne, Cologne, Germany

    Erland Erdmann

  4. University of Nancy, Nancy, France

    Faiez Zannad

  5. Sticares Cardiovascular Research Institute, Rhoon, Netherlands

    Willem J. Remme

  6. Department of Cardiology, University Hospital La Paz, Madrid, Spain

    José L. Lopez-Sendon

  7. Pharmacology Department, Pitié-Salpêtrière Hospital, APHP, UPMC, Paris, France

    Philippe Lechat

  8. University Hospital Zürich, Zürich, Switzerland

    Ferenc Follath

  9. Stockholm Heart Centre, Stockholm, Sweden

    Christer Höglund

  10. Myasnikow Institute of Cardiology, Moscow, Russia

    Viacheslav Mareev

  11. National Institute of Cardiology, Warsaw, Poland

    Zygmunt Sadowski

  12. Cardiology Department, Santa Cruz Hospital, Carnaxide, Portugal

    Ricardo J. Seabra-Gomes

  13. Golden Jubilee National Hospital, Clydebank, Glasgow, UK

    Henry J. Dargie

Authors
  1. Siobhan Gallanagh
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  2. Davide Castagno
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  3. Ben Wilson
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  4. Erland Erdmann
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  5. Faiez Zannad
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  6. Willem J. Remme
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  10. Christer Höglund
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  11. Viacheslav Mareev
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  13. Ricardo J. Seabra-Gomes
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  14. Henry J. Dargie
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  15. John J. V. McMurray
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Corresponding author

Correspondence to John J. V. McMurray.

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Functional Status Questionnaire (FSQ) in Heart Failure

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Gallanagh, S., Castagno, D., Wilson, B. et al. Evaluation of the Functional Status Questionnaire in Heart Failure: A Sub-study of the Second Cardiac Insufficiency Bisoprolol Survival Study (CIBIS-II). Cardiovasc Drugs Ther 25, 77–85 (2011). https://doi.org/10.1007/s10557-011-6284-x

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  • DOI: https://doi.org/10.1007/s10557-011-6284-x

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