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Comprehensive Functional Mapping Scheme for Non-Invasive Primary Sensorimotor Cortex Mapping

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Abstract

We introduce a novel multimodal scheme for primary sensorimotor hand area (SM1ha) mapping integrating multiple functional indicators from functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG). Ten right-handed healthy subjects (19–33 years; 5 females, 5 males) and four patients (24–64 years; 2 females, 2 males) suffering from space-occupying brain lesion close to the central sulcus were studied. Functional indicators of the SM1ha were obtained from block-design fMRI motor protocol, and six MEG protocols: somatosensory evoked fields to electrical median-nerve stimulation, mu-rhythm suppression (~10 and ~20 Hz), corticomuscular coherence, and corticokinematic coherence with and without finger contacts. To assess the spatial spread of the functional indicators, their coordinates were subjected to principal component analysis to produce a centered ellipsoid with axis along principal components. Five to seven functional indicators were obtained for each participant. In all participants, the ellipsoid co-localized with the anatomical SM1ha. In healthy subjects, 50–100 % of functional indicators were located within 10 mm from the center of the ellipsoid. In patients, 17–100 % of functional indicators were located within 10 mm from the center of the ellipsoid. In conclusion, the multimodal scheme proposed led to a functional mapping of SM1ha that co-localized with anatomical SM1ha in all participants. The spread of the SM1ha functional indicators in some patients with brain lesions highlights the potential benefit of the proposed multimodal approach to assess the reliability of the non-invasive SM1ha mapping.

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Acknowledgments

Mathieu Bourguignon benefits of a research Grant from the FRIA (FRS-FNRS, Belgium). Xavier De Tiège is Clinicien-Chercheur Spécialiste at the FRS-FNRS, Belgium. This work was supported by a “Brains Back to Brussels” Grant to Veikko Jousmäki from the Institut d’Encouragement de la Recherche Scientifique et de l’Innovation de Bruxelles (Brussels, Belgium), the Fonds de la Recherche Scientifique (FRS-FNRS, Belgium, Research Convention 3.4611.08), and the Academy of Finland (National Centers of Excellence Program 2006–2011, Grant #129678; Grant #218072). We thank Helge Kainulainen and Ronny Schreiber at the Brain Research Unit (Aalto University, Finland) for technical support.

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  1. Laboratoire de Cartographie fonctionnelle du Cerveau, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

    Mathieu Bourguignon, Brice Marty, Vincent Wens, Marc Op de Beeck, Patrick Van Bogaert, Serge Goldman & Xavier De Tiège

  2. Brain Research Unit, O.V. Lounasmaa Laboratory, School of Science, Aalto University, FI-00076 AALTO, Espoo, Finland

    Veikko Jousmäki

  3. Department of Neuroradiology, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

    Mustapha Nouali, Thierry Metens & Boris Lubicz

  4. Department of Neurosurgery, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

    Florence Lefranc, Michael Bruneau & Olivier De Witte

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  1. Mathieu Bourguignon
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  2. Veikko Jousmäki
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  3. Brice Marty
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  4. Vincent Wens
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  10. Florence Lefranc
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  13. Serge Goldman
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  14. Xavier De Tiège
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Correspondence to Mathieu Bourguignon.

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Bourguignon, M., Jousmäki, V., Marty, B. et al. Comprehensive Functional Mapping Scheme for Non-Invasive Primary Sensorimotor Cortex Mapping. Brain Topogr 26, 511–523 (2013). https://doi.org/10.1007/s10548-012-0271-9

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  • DOI: https://doi.org/10.1007/s10548-012-0271-9

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