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Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.

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References

  1. Nervous System Diseases. Manual for Physicians, Eds. N. N. Yakhno and D. R. Shtulman [in Russian], Moscow (2003), Vol. 1.

  2. E. I. Gusev, V. I. Skvortsova, N. F. Myasoedov, et al., Zh. Nevrol. Psikhiatr., No. 6, 26–34 (1997).

  3. Stroke: Diagnosis, Treatment, Prevention, Eds. Z. A. Suslina and M. A. Piradov [in Russian], Moscow (2008).

  4. G. A. Romanova, Dysregulation Pathology. Manual for Physicians and Biologists, Ed. G. N. Kryzhanovskii [in Russian], Moscow (2002), P. 605–615.

  5. G. A. Romanova, D. N. Silachev, F. M. Shakova, et al., Byull. Eksp. Biol. Med., 142, No. 12, 618–621 (2006).

    Google Scholar 

  6. S. B. Seredenin and T. A. Gudasheva, Invention Application, Registration No. 2009105176, priority of 16.02.2009.

  7. B. Connor and M. Dragunow, Brain Res. Brain Res. Rev., 27, No. 1, 1–39 (1998).

    Article  PubMed  CAS  Google Scholar 

  8. R. U. Ostrovskaya, G. A. Romanova, L. V. Barskov, et al., Behav. Pharmacol., 10, No. 5, 549–553 (1999).

    Article  PubMed  CAS  Google Scholar 

  9. S. J. Pollack and S. J. Harper, Drug News Perspect., 15, No. 5, 268–277 (2002).

    Article  PubMed  CAS  Google Scholar 

  10. B. D. Watson, W. D. Dietrich, R. Busto, et al., Ann. Neurol., 17, No. 5, 497–504 (1985).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    S. B. Seredenin, G. A. Romanova, T. A. Gudasheva, F. M. Shakova & T. A. Antipova

  2. Department of Brain Studies, Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia

    I. V. Barskov & E. V. Stelmashuk

Authors
  1. S. B. Seredenin
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  2. G. A. Romanova
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  3. T. A. Gudasheva
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  4. F. M. Shakova
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  5. I. V. Barskov
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  6. E. V. Stelmashuk
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  7. T. A. Antipova
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Corresponding author

Correspondence to T. A. Gudasheva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 10, pp. 406–409, October, 2010

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Seredenin, S.B., Romanova, G.A., Gudasheva, T.A. et al. Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex. Bull Exp Biol Med 150, 432–435 (2011). https://doi.org/10.1007/s10517-011-1161-y

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  • DOI: https://doi.org/10.1007/s10517-011-1161-y

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