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Biological therapy in inflammatory rheumatic diseases: issues in Central and Eastern European countries

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Abstract

Biological drugs revolutionized the treatment of inflammatory rheumatic diseases. Access to treatment presents substantial variability across Europe. The economic level of a particular country as well as administrative restrictions have been proved as determining factors of biological drug uptake. The objective of this paper was to provide an overview of biological treatment in six selected Central and Eastern European (CEE) countries, namely in the Bulgaria, Czech Republic, Hungary, Poland, Romania and Slovakia. The literature is summarized with regard to the epidemiology, disease burden and use of biological agents in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Moreover, an estimate is provided on the prevalence and number of patients with biological treatment based on international and local sources. In view of the limited availability of information and uncertainty in data, there is an urgent need for development of systematic and comprehensive data collection in inflammatory rheumatic diseases in CEE countries.

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Notes

  1. Source: ATTRA registry, available at www.attra.registry.cz.

  2. The validity of IMS data are not known due to the fact that IMS data covers the retail channel only, a number of companies deliver products directly to hospitals without other distribution channels, and secondly a significant proportion of biologicals are re-exported (parallel export).

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Acknowledgments

The authors gratefully acknowledge Fanni Rencz M.D. (Ph.D. student at Semmelweis University Budapest) for her assistance with the patient number estimates. The study was supported by an independent grant from the Centre for Public Affairs Studies Foundation.

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Authors and Affiliations

  1. Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., Budapest, 1093, Hungary

    Márta Péntek & László Gulácsi

  2. Department of Rheumatology, Flór Ferenc County Hospital, Semmelweis tér 1, Kistarcsa, 2143, Hungary

    Márta Péntek

  3. National Institute of Rheumatology and Physiotherapy, 1023 Frankel Leó u. 25-29, Budapest, Hungary

    Gyula Poór

  4. Rheumatology Department, Wroclaw University Hospital, Borowska 213, 50-556, Wrocław, Poland

    Piotr Wiland

  5. Department of Rheumatology, First Faculty of Medicine, Prague and Rheumatology Institute, Charles University, Praha 2, Na Slupi 4, 120 00, Prague, Czech Republic

    Martina Olejárová

  6. Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Rybacka 1, Szczecin, Poland

    Marek Brzosko

  7. Centrul de Boli Reumatismale Dr. Ion Stoia, Strada Thomas Masaryk 5, Bucharest, Romania

    Catalin Codreanu

  8. Doctoral School, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary

    Nóra Brodszky

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  1. Márta Péntek
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Péntek, M., Poór, G., Wiland, P. et al. Biological therapy in inflammatory rheumatic diseases: issues in Central and Eastern European countries. Eur J Health Econ 15 (Suppl 1), 35–43 (2014). https://doi.org/10.1007/s10198-014-0592-6

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