Antimicrobial resistance in community-acquired urinary tract infections: results from the Korean Antimicrobial Resistance Monitoring System

https://doi.org/10.1007/s10156-010-0178-xGet rights and content

Abstract

The Korean Antimicrobial Resistance Monitoring System was established and the first nationwide surveillance of bacterial uropathogens was conducted during the period from January 2008 to June 2009. With the cooperation of 34 medical centers throughout South Korea, a total of 1994 strains belonging to clinically relevant bacterial uropathogens were collected from patients with community-acquired urinary tract infections (UTIs). To compare with past data, understand a trend of antimicrobial resistance, and ultimately determine new regimens for empirical treatment of uncomplicated cystitis, the antimicrobial susceptibilities against Escherichia coli in uncomplicated cystitis to commonly prescribed drugs were investigated. In uncomplicated cystitis, the most prevalent causative organism was E. coli (72.7%), followed by Enterococcus faecalis (10.7%) and Klebsiella pneumoniae (3.5%). Among E. coli isolates from acute uncomplicated cystitis, 38.5% were susceptible to ampicillin, 80.7% to amoxicillin/clavulanate, 67.3% to trimethoprim/sulfamethoxazole, 74.6% to ciprofloxacin, 77.5% to levofloxacin, 86.0% to cefazolin, 86.1% to cefuroxime, 93.6% to cefpodoxime, 94.7% to ceftriaxone, 99.5% to amikacin, 80.9% to tobramycin, and 76.6% to gentamicin. An increasing tendency of resistance to ciprofloxacin (24.8%) has been observed compared with the similar studies in 2006 (23.4%) and 2002 (15.2%) from patients with uncomplicated cystitis. These data provide much needed information on the prevalence of antimicrobial resistance in community-acquired UTIs in South Korea and will be a useful reference for future periodic surveillance studies.

Cited by (62)

  • Antibacterial and antibiofilm efficacy of Ag NPs, Ni NPs and Al<inf>2</inf>O<inf>3</inf> NPs singly and in combination against multidrug-resistant Klebsiella pneumoniae isolates

    2021, Journal of Trace Elements in Medicine and Biology
    Citation Excerpt :

    Mirnejhad et al. also indicated that more than 55 % of ESBL producing K. pneumoniae strains were multi-drug resistant and revealed the highest resistance to meropenem and imipenem antibiotics [47]. From 80 K. pneumoniae isolates from UTIs patients in a Korean study, resistance to ampicillin was the highest similar to our studies but antibiotic-resistant to amikacin was lowest among the isolates [48]. Another study performed in Spanish hospitals on UTIs K. pneumoniae isolates confirmed our antibiotic susceptibility testing in which all 159 K. pneumoniae strains were resistant to ampicillin [44].

  • Comparison of a combined regimen of fosfomycin and ciprofloxacin with ciprofloxacin alone as antimicrobial prophylaxis for transrectal prostate biopsy in the era of high fluoroquinolone-resistant rectal flora

    2021, Prostate International
    Citation Excerpt :

    To mitigate infectious complications, FQ has been routinely used as a first-line prophylactic antibiotic because of its high penetration into the prostate gland and its safety.23,24 However, recent studies reported that antibiotic resistance and infectious complications after TRUSPB are rising globally, which is considered a result of the increase in FQ-resistant E. coli.18-20,25,26 Regarding this, many physicians, including urologists, not only questioned the effectiveness of FQ as prophylaxis for TRUSPB but also suggested alternatives.

  • Mitigation of antibiotic resistance in a pilot-scale system treating wastewater from high-speed railway trains

    2020, Chemosphere
    Citation Excerpt :

    Enterococci are common symbiotic bacterium of human and animal digestive tract that are widely distributed in the natural environment. They can cause infections (e.g., urinary tract, skin, and soft tissue infections), sepsis, pericarditis, meningitis, and even life-threatening abdominal infection (Jean and Hsueh, 2011; Lee et al., 2011; Arias et al., 2010). Enterococci could be detected in the urban wastewater and sludge at a high level (Tong et al., 2017; Sahlstrom et al., 2009).

  • Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis

    2019, International Journal of Infectious Diseases
    Citation Excerpt :

    GBS prevalence in SSTI isolates from children (excluding neonatal omphalitis) was 1.05% (95% CI 0.15–7.09%), compared with 1.68% (95% CI 0.58–4.78%) in studies that included only adults, but this difference was unsupported by evidence of between-subgroup heterogeneity (p = 0.65). Forty-two sources reporting GBS in UTI were included (Weiner et al., 2016; European Centre for Disease Prevention and Control (ECDC), 2013; European Centre for Disease Prevention and Control (ECDC), 2017; Bouza et al., 2001a; Lee et al., 2004; Jodra et al., 2006; Phu et al., 2016; Sabra and Abdel-Fattah, 2012; Zhanel et al., 2010; Behzadnia et al., 2014; Agodi et al., 2013; Alvarez Lerma et al., 2005; Andreu et al., 2005; Bauserman et al., 2013; Bouza et al., 2001b; Brabazon et al., 2012; Choi et al., 2016; Greenhow et al., 2014; Guerreiro et al., 2012; Hanna-Wakim et al., 2015; Hayami et al., 2013; Hedin et al., 2002; Hooton et al., 2013; Karlowsky et al., 2011; Kazemier et al., 2014; Kiffer et al., 2007; Kronenberg et al., 2011; Laupland et al., 2007; Lee et al., 2011; Magliano et al., 2012; Malmartel and Ghasarossian, 2016; Matsumoto et al., 2011; Monsen et al., 2014; Moulton et al., 2017; Rodriguez et al., 2005; Sorlozano et al., 2014; Zajac-Spychala et al., 2016; Naber et al., 2008). GBS was found in 1.09% (95% CI 0.77–1.54%) of UTI isolates, with a higher prevalence for community (1.61%, 95% CI 1.13–2.30%) than hospital UTI (0.72%, 95% CI 0.43–1.22%) (between-subgroups p = 0.01) (Table 4, Figure 6).

View all citing articles on Scopus
View full text