Abstract
The study presented here was performed to evaluate the need for aspiration in patients with amebic liver abscess (ALA). Patients older than 12 years with a diagnosis of ALA based on clinical features, ultrasound results, and positive amebic serology were included in the study (n=144). Serological testing was performed to detect the presence of immunoglobin G antibody against Entamoeba histolytica, and a value of more than 0.4 optical density units was considered positive. All patients were given intravenous metronidazole (500 mg every 8 h) and their clinical progress and need for abscess aspiration was documented. Fever, pain in the upper abdomen, and tender hepatomegaly was seen in 133 (92.3%), 128 (88.8%), and 144 (100%) patients, respectively. Multiple abscesses were seen in 40 (27.7%) patients. Six (4.1%) patients died. Seventy-one (49.3%) patients responded to metronidazole alone. A total of 73 (50.69%) patients required aspiration of the abscess. This study shows that almost 50% of the patients with amebic liver abscess failed to respond to metronidazole and required aspiration.
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Peters RS, Gitlin N, Libke RD (1982) Amoebic liver diseases. Ann Rev Med 32:161–174
Salles JM, Moraes LA, Salles MC (2003) Hepatic amebiasis. Braz J Infect Dis 7:96–110
Banerjee R, Tandon A (2000) Amoebic liver abscess: is response to metronidazole declining? Letter to the editor. Trop Gastroenterol 21:88
Saraswat VA, Agarwal DK, Baijal SS, Roy S, Choudhuri G, Dhiman RK, et al. (1992) Percutaneous catheter drainage of amoebic liver abscess. Clin Radiol 45:187–189
Thompson JE Jr, Forlenza S, Verma R (1985) Amoebic liver abscess: a therapeutic approach. Rev Infect Dis 7:171–179
Weinke T, Grobusch MP, Guthoff W (2002) Amebic liver abscess—rare need for percutaneous treatment modalities. Eur J Med Res 7:25–29
Ralls PW (1998) Focal inflammatory disease of the liver. Radiol Clin North Am 36:377–389
Maneschy LAP (1974) Abscesso amebiano na Amazonia. Thesis. (Livre Docencia) Centro Biomedico da Universidade Federal do Para.Belem
Sharma MP, Sarin SK, Acharya SK (1984) Left lobe amoebic abscess of liver — a distinct clinical entity. J Assoc Phys India 32:477
Sharma MP, Sarin SK (1990) Inferior vena caval obstruction due to amoebic liver abscess. J Assoc Phys India 30:243
Sharma MP, Dasarathy S, Verma N, Sushma S, Shukla DK (1996) Prognostic markers in amebic liver abscess: a prospective study. Am J Gastro 91:2584–2588
Sharma MP, Dasarathy S (1993) Amebic liver abscess. Trop Gastroenterol 14:3–9
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Khanna, S., Chaudhary, D., Kumar, A. et al. Experience with aspiration in cases of amebic liver abscess in an endemic area. Eur J Clin Microbiol Infect Dis 24, 428–430 (2005). https://doi.org/10.1007/s10096-005-1338-2
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DOI: https://doi.org/10.1007/s10096-005-1338-2