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Bone mineral density in ambulatory patients with multiple sclerosis

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Abstract

Multiple sclerosis (MS) may be associated with reduced bone mass and higher frequency of osteoporosis. Femoral and spinal bone mineral density (BMD) in 70 ambulatory MS patients (46 females and 24 males) was compared with 100 sex-, age-, and BMI-matched control individuals. BMD was reduced in male patients (lumbar spine 0.976 ± 0.114 g/cm2 compared with 1.059 ± 0.147 g/cm2 in controls, p = 0.024, total hip 0.946 ± 0.136 g/cm2 compared to 1.036 ± 0.118 g/cm2 in controls, p = 0.008, femoral neck 0.812 ± 0.136 g/cm2 compared with 0.887 ± 0.135 g/cm2 in controls p = 0.042), and only in the total hip in female patients (0.88 ± 0.127 g/cm2 compared with 0.935 ± 0.112 g/cm2 in controls, p = 0.018). Multivariate analysis demonstrated that the predominantly affected site was the hip. MS patients exhibit increased frequency of low bone mass compared with controls. Further studies should assess the etiologic factors and employ appropriate therapies.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece

    Chrissa Sioka, Andreas Fotopoulos & Athanasia Georgiou

  2. Department of Neurology, University Hospital of Ioannina, Ioannina, Greece

    Stylianos Papakonstantinou, Sofia Tsouli, Sygliti-Henrietta Pelidou & Athanassios P. Kyritsis

  3. Neurosurgical Research Institute, University of Ioannina, Ioannina, Greece

    Stylianos Papakonstantinou, Sygliti-Henrietta Pelidou & Athanassios P. Kyritsis

  4. Department of Public Health, University of Patras, Patras, Greece

    Yiannis Alamanos

  5. Department of Medical Physics, University Hospital of Ioannina, Ioannina, Greece

    John Kalef-Ezra

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  1. Chrissa Sioka
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  2. Stylianos Papakonstantinou
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  3. Andreas Fotopoulos
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  4. Yiannis Alamanos
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  5. Athanasia Georgiou
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  6. Sofia Tsouli
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  7. Sygliti-Henrietta Pelidou
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  8. Athanassios P. Kyritsis
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  9. John Kalef-Ezra
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Correspondence to Chrissa Sioka.

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Sioka, C., Papakonstantinou, S., Fotopoulos, A. et al. Bone mineral density in ambulatory patients with multiple sclerosis. Neurol Sci 32, 819–824 (2011). https://doi.org/10.1007/s10072-011-0623-3

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  • DOI: https://doi.org/10.1007/s10072-011-0623-3

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