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Health-related quality of life assessed by LupusQoL questionnaire and SF-36 in Turkish patients with systemic lupus erythematosus

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Abstract

The LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus. We conducted this study to compare the efficiency of LupusQoL-TR (validated Turkish version of the LupusQoL questionnaire) with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Turkish patients with lupus. Both questionnaires were conducted at a single visit to the clinic. Disease activity was measured with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Associations between the LupusQoL-TR and SF-36 domains were examined while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman’s correlation coefficients, and Students t test were performed to analyze the data. A total of 113 consecutive patients with lupus (F/M 108:5, mean age 40.6 ± 11.9 years, mean disease duration 8.5 ± 7.0 years) were included, and 69 % of these were active. The median SLEDAI score was 2 (0–24), the mean global LupusQoL-TR score was 60.9 ± 23.3, and the mean SF-36 score was 41.2 ± 9.0. There was a significant correlation between LupusQoL-TR and SF-36 mean scores (r = 0.83; p < 0.001). QoL assessed by LupusQoL-TR and SF-36 did not correlate with disease activity (r = −0.11; p = 0.244 and r = −0.03; p = 0.721, respectively). LupusQoL-TR and SF-36 questionnaires were beneficial instruments in evaluating HRQoL in Turkish lupus patients. However, LupusQoL-TR and SF-36 were not associated with SLEDAI scores, which suggested that QoL might be affected by other factors besides disease activity, especially in clinically inactive or mildly active patients.

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Acknowledgments

The authors would like to thank Mary Gawlicki and Lee-Suan Teh for supplying the validated Turkish version of the LupusQoL-TR and permitting us to use this copyrighted questionnaire. We also would like to thank David Chapman for the language editing of the article.

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Authors and Affiliations

  1. Department of Rheumatology, School of Medicine, Marmara University, 34890, Pendik, Istanbul, Turkey

    Sibel Yilmaz-Oner, Pamir Atagunduz & Haner Direskeneli

  2. Department of Family Medicine, School of Medicine, Istanbul Bilim University, Istanbul, Turkey

    Can Oner

  3. School of Medicine, Marmara University, Istanbul, Turkey

    Fatih Mert Dogukan, Toklong Filam Moses, Kubra Demir & Nazar Tekayev

  4. Department of Nephrology, School of Medicine, Marmara University, Istanbul, Turkey

    Serhan Tuglular

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  1. Sibel Yilmaz-Oner
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Correspondence to Sibel Yilmaz-Oner.

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Yilmaz-Oner, S., Oner, C., Dogukan, F.M. et al. Health-related quality of life assessed by LupusQoL questionnaire and SF-36 in Turkish patients with systemic lupus erythematosus. Clin Rheumatol 35, 617–622 (2016). https://doi.org/10.1007/s10067-015-2930-1

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