Abstract
There is extensive evidence for influence of gut microbiota on health. Exclusive enteral nutrition (EEN) possibly changes gut microbiota, but the exact pathophysiological role is unknown. EEN has been shown to have an anti-inflammatory effect in children with Mb Crohn, an inflammatory bowel disease. The intestinal tract is very scarcely studied in children with juvenile idiopathic arthritis (JIA), but data points to an immunologically important role. The aim of this study was to explore if EEN had any anti-inflammatory effect in children with JIA. The first patient enrolled in the study was followed for 1 year. She had onset of severe polyarticular disease at 3.2 years of age, negative in RF, anti-CCP, ANA, and HLA-B27. She was included in the study at 7.4 years of age. Exclusive enteral nutrition was given in two periods of almost 7 weeks each, several months apart, during the year of the study. Clinical and laboratory status were assessed before, during, and after treatment periods. In this patient, EEN had remarkable anti-inflammatory effect that was sustained for months after each of two separate treatment periods. Exclusive enteral nutrition is a possible anti-inflammatory treatment in patients with JIA, but to what extent EEN is effective in other children with JIA needs to be explored, as well as the possible pathophysiological role of EEN in those children.
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Acknowledgments
The author is grateful to Professor Kjell Alving for constructive help with the figures, Professor Yigael Finkel and Dr. Niklas Nyström for their support and advice regarding pediatric gastroenterology, and Dr. Ingemar Swenne for constructive criticism. This work was supported by grants from the Department of Women’s and Children’s Health, Uppsala University Hospital, Uppsala, and the Gillbergska Foundation, Uppsala.
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Berntson, L. Anti-inflammatory effect by exclusive enteral nutrition (EEN) in a patient with juvenile idiopathic arthritis (JIA): brief report. Clin Rheumatol 33, 1173–1175 (2014). https://doi.org/10.1007/s10067-014-2672-5
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DOI: https://doi.org/10.1007/s10067-014-2672-5