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Serum levels of IL-33 is increased in patients with ankylosing spondylitis

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Abstract

Interleukin-33 (IL-33) is implicated in rheumatoid arthritis with effects of promoting tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) productions, which have been demonstrated to play a pivotal role in ankylosing spondylitis (AS). However, changes of IL-33 levels and its effects in AS have not been investigated. Eighty-nine and 178 healthy controls were included in the current study. Erythrocyte sedimentation rate, serum levels of C-reactive protein, IL-17, and IL-33 were determined. Effects of IL-33 on TNF-α and IL-6 productions were investigated. Effects of IL-33 on neutrophil migration were also evaluated. Serum levels of IL-33 were elevated in AS patients. Moreover, IL-33 was significantly higher in active AS patients according to Bath Ankylosing Spondylitis Disease Activity Index. IL-33 concentrations in serum were positively correlated with TNF-α and IL-17 levels (IL-33 and TNF-α, r = 0.54, P < 0.01; IL-33 and IL-17, r = 0.47, P < 0.01). IL-33 dose-dependently enhanced TNF-α and IL-6 productions by peripheral blood mononuclear cells (PBMCs) responding to lipopolysaccharide. IL-33 induced neutrophil migration only in higher doses (≥10 ng/ml). Serum levels of IL-33 were elevated in AS patients. IL-33 may play a role in AS development via enhancing TNF-α production by PBMCs and inducing neutrophil migration.

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Source of funding

This work was supported by Major Science and Technology Planning Project of Guangdong Province, China (No. 2003C30202).

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Authors and Affiliations

  1. Department of Spinal Surgery, Huangpu Division of First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

    Guo-Wei Han, Li-Wen Zeng, Chun-Xiang Liang, Bai-Ling Cheng, Bing-Sheng Yu, Hao-Miao Li & Shao-Yu Liu

  2. Department of Epidemiology and Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China

    Fang Fang Zeng

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  1. Guo-Wei Han
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Correspondence to Shao-Yu Liu.

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Han, GW., Zeng, LW., Liang, CX. et al. Serum levels of IL-33 is increased in patients with ankylosing spondylitis. Clin Rheumatol 30, 1583–1588 (2011). https://doi.org/10.1007/s10067-011-1843-x

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  • DOI: https://doi.org/10.1007/s10067-011-1843-x

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