Abstract
Pranlukast is a cysteinyl leukotriene receptor I antagonist (LTRAs) approved for treatment of asthma in Japan since 1995. Compared to other LTRAs, such as zafilukast and montelukast, only few cases with Churg-Strauss syndrome (CSS) have been reported in association with treatment with pranlukast. We describe a 17-year-old Japanese male patient who developed CSS with a 13 month history of mild asthma receiving pranlukast for 11 months without systemic and/or inhaled corticosteroid administration prior to development of CSS. From the aspect of temporal relationship between treatment with pranlukast and development of CSS, a direct induction of CSS by pranlukast is suggested in our case.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- ANCA:
-
Antineutrophil cytoplasmic antibodies
- CSS:
-
Churg–Strauss syndrome
- LTRA:
-
Leukotriene receptor I antagonist
References
Churg J, Strauss L (1951) Allergic granulomatosis, allergic angiitis and periarteritis nodosa. Am J Pathol 27:277–301
Stirling RG, Chung KF (1999) Leukotriene antagonists and Churg–Strauss syndrome: the smoking gun. Thorax 54:865–866
Wechsler ME, Grarpoestad E, Flier SR et al. (1998) Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. JAMA 279:455–457
Wechsler ME, Finn D, Gunawardena D et al. (2000) Churg–Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest 117:708–713
Kinoshita M, Shiraishi T, Koga T, Ayabe M, Rikimaru T Oizumi K (1999) Churg–Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast. J Allergy Clin Immunol 103:534–535
Hashimoto M, Fujishima T, Tanaka H et al. (2001) Churg–Strauss syndrome after reduction of inhaled corticosteroid in a patient treated with pranlukast for asthma. Intern Med 40:432–434
Hayashi S, Furuya S, Imamura H (2001) Fulminant eosinophilic endomyocarditis in an asthmatic patient treated with pranlukast after corticosteroid withdrawal. Heart 86:E7
Clark T, Busse W, Bousquet J et al. (2002) Pocket guide for asthma management and prevention. Global Initiative for Asthma. NIH publication No. 02-3659A. http:/www.ginasthma.com
Masi AT, Hunder GG, Lie JT et al. (1990) The American College of Rheumatology 1990 criteria for the classicication of Churg–Strauss syndrome (allergic granulomatosis angiitis). Arthritis Rheum 22:1094–1100
Solans R, Bosch JA, Selva A, Orriols R, Vilardell M (2002) Montelukast and Churg-Strauss syndrome. Thorax 57:183–185
Guilpain P, Viallard JF, Lagarde P et al. (2002) Churg–Strauss syndrome in two patients receiving montelukast. Rheumatology 41:535–539
Soy M, Ozer H, Canataroglub, Gumurdulu D, Erken E (2002) Vasuculitis induced by zafirlukast therapy. Clin Rheumatol 21:328–329
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kobayashi, S., Ishizuka, S., Tamura, N. et al. Churg–Strauss syndrome (CSS) in a patient receiving pranlukast. Clin Rheumatol 22, 491–492 (2003). https://doi.org/10.1007/s10067-003-0791-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-003-0791-5