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Central nervous system neuroblastic tumor with FOXR2 activation presenting both neuronal and glial differentiation: a case report

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Abstract

A subset of central nervous system neuroblastomas (CNS NB), rare primary embryonal CNS tumors, has been encompassed in CNS NB with FOXR2 activation (CNS NB-FOXR2) and usually shows the primitive neuronal architecture and occasional neurocytic differentiation. Here, we report a rare case of 3-year-old female with uncommon morphology of CNS embryonal tumor with FOXR2 activation presenting bidirectional differentiation to neurocytic small primitive cells and astrocytic spindle cells both of which are positive for synaptophysin and GFAP. Ultrastructural study also showed that there were presynaptic structure and intermediate filament in the tumor cells, suggesting glioneuronal differentiation. This case indicates the possibility of CNS neuroblastic tumor to differentiate neuronal and glial lineages.

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Authors and Affiliations

  1. Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan

    Takuya Furuta, Mayuko Moritsubo, Hiroko Muta & Koichi Ohshima

  2. Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan

    Motohisa Koga, Satoru Komaki, Hideo Nakamura & Motohiro Morioka

  3. Department of Neuropathology, St. Mary’s Hospital, Kurume, Japan

    Yasuo Sugita

Authors
  1. Takuya Furuta
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  2. Mayuko Moritsubo
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  3. Hiroko Muta
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  4. Motohisa Koga
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  5. Satoru Komaki
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  6. Hideo Nakamura
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  7. Motohiro Morioka
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  8. Koichi Ohshima
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  9. Yasuo Sugita
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Correspondence to Takuya Furuta.

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Furuta, T., Moritsubo, M., Muta, H. et al. Central nervous system neuroblastic tumor with FOXR2 activation presenting both neuronal and glial differentiation: a case report. Brain Tumor Pathol 37, 100–104 (2020). https://doi.org/10.1007/s10014-020-00370-2

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  • DOI: https://doi.org/10.1007/s10014-020-00370-2

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