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Primary central nervous system histiocytic sarcoma

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Abstract

Histiocytic sarcoma is a rare, lymphohematopoietic malignant neoplasm composed of tumor cells showing morphologic and immunophenotypic features of mature tissue histiocytes. Involvement of the central nervous system (CNS) as either a part of a systemic disease or as a primary lesion has rarely been described so far. We present a case of primary CNS histiocytic sarcoma in an adult patient and review the literature on this rare entity.

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References

  1. Bataille B, Delwail V, Menet E, Vandermarcq P, Ingrand P, Wager M, Guy G, Lapierre F (2000) Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg 92:261–266

    Article  PubMed  CAS  Google Scholar 

  2. Cao M, Eshoa C, Schultz C, Black J, Zu Y, Chang CC (2007) Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature. Arch Pathol Lab Med 131(2):301–305

    PubMed  Google Scholar 

  3. Cheuk W, Walford N, Lou J, Lee AK, Fung CF, Au KH, Mak LS, Chan JK (2001) Primary histiocytic lymphoma of the central nervous system: a neoplasm frequently overshadowed by a prominent inflammatory component. Am J Surg Pathol 25(11):1372–1379

    Article  PubMed  CAS  Google Scholar 

  4. Colovic N, Jurisic V, Colovic M (2007) Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature. J BUON 12(4):539–542

    PubMed  CAS  Google Scholar 

  5. Egeler RM, Schmitz L, Sonneveld P, Mannival C, Nesbit ME (1995) Malignant histiocytosis: a reassessment of cases formerly classified as histiocyte neoplasms and review of the literature. Med Pediatr Oncol 25:1–7

    Article  PubMed  CAS  Google Scholar 

  6. Lauritzen AF, Delsol G, Hansen NE, Horn T, Ersbøll J, Hou-Jensen K, Ralfkiaer E (1994) Histiocytic sarcomas and monoblastic leukemias: a clinical, histologic, and immunophenotypic study. Am J Clin Pathol 102:45–54

    PubMed  CAS  Google Scholar 

  7. Sun W, Nordberg ML, Fowler MR (2003) Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol 27(2):258–265

    Article  PubMed  Google Scholar 

  8. Torres CF, Korones DN, Powers JM, Vadasz AG (1996) Primary leptomeningeal histiocytic lymphoma in a young child. Med Pediatr Oncol 27:547–550

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Yosef Laviv.

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Laviv, Y., Zagzag, D., Fichman-Horn, S. et al. Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol 30, 192–195 (2013). https://doi.org/10.1007/s10014-012-0123-z

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  • DOI: https://doi.org/10.1007/s10014-012-0123-z

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