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Spättoxizität und Survivorship bei Keimzelltumoren

Delayed toxicity and survivorship with germ cell tumors

  • Leitthema
  • Published:
Der Onkologe Aims and scope

Zusammenfassung

Hintergrund

Keimzelltumoren zählen neben dem M. Hodgkin zu den malignen Erkrankungen mit den aktuell höchsten Heilungsraten, auch noch in weit fortgeschrittenen oder metastasierten Erkrankungsstadien. Dies ist multimodalen Therapiekonzepten zu verdanken, die aber nicht nur mehr Kuration versprechen, sondern auch Nebenwirkungen im akuten Verlauf und Langzeitverlauf potenzieren. Somit rücken die Prävention, das frühzeitige Erkennen und die Behandlung von therapieassoziierten medizinischen, aber auch psychosozialen Langzeiteffekten und Spätkomplikationen immer mehr in den Fokus, um die Lebensqualität dieser ehemaligen Patienten auch nach ihrer Erkrankung zu erhalten bzw. zu verbessern.

Material und Methoden

Recherche der Literatur und Auswertung klinischer Studien.

Ergebnisse

Die körperlichen Folgeschäden, die jedes Organsystem betreffen können und auch Zweitmalignome und Infertilität umfassen, sind nicht selten neben Rezidivangst die Ursache einer Reihe von psychosozialen Problemen, welche die Wiedereingliederung der ehemaligen Patienten in den normalen Alltag erschweren.

Schlussfolgerung

Survivorship-Programme bieten dieser Patientengruppe die Möglichkeit einer dynamischen Unterstützung auf dem Weg zum Langzeitüberlebenden.

Abstract

Context

Germ cell tumors and Hodgkin’s lymphoma are currently the malignant diseases with the highest cure rates. Even in advanced or metastasized disease stages these neoplasms can be cured by multimodal treatment approaches. Nevertheless, the curative treatment modalities applied, e.g. intensive systemic chemotherapy, radiotherapy and surgery, have side effects directly during the course of treatment and even delayed toxicity can occur, which may affect the health and quality of life of cancer survivors. This is why prevention and early detection as well as adequate treatment of toxic side effects affecting medical and psychosocial aspects are essential to maintain or improve patient quality of life.

Material and methods

Research of literature and analysis of clinical trials.

Results

Not only chronic dysfunction of many organ systems (e.g. cardiovascular risk) but also secondary cancer, infertility and the fear of relapse are common reasons for a variety of psychosocial problems which can prevent cancer survivors from living a normal daily life after curative treatment.

Conclusion

Survivorship programs offer these patients the opportunity of dynamic support adapted to their needs on the way to patients becoming long-term survivors.

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Authors and Affiliations

  1. Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland

    K. Oechsle, G. Schilling, C. Oing & C. Bokemeyer

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  1. K. Oechsle
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  2. G. Schilling
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  3. C. Oing
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  4. C. Bokemeyer
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Correspondence to K. Oechsle.

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Oechsle, K., Schilling, G., Oing, C. et al. Spättoxizität und Survivorship bei Keimzelltumoren. Onkologe 19, 573–581 (2013). https://doi.org/10.1007/s00761-013-2472-6

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  • DOI: https://doi.org/10.1007/s00761-013-2472-6

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