Abstract
Previous studies have demonstrated the key regulatory roles played by microRNAs (miRNAs) in influenza virus-host interactions. To gain more insight into the contribution of miRNAs to the host immune response, spleen tissues from mice infected with A/Swine/GD/2/12 (H1N1) virus were harvested 5 days postinfection, and miRNA deep sequencing was performed. The results showed that 50 miRNAs were modulated. Interestingly, pathway analysis of miRNAs and targets showed that upregulated miR-124-3p interacts with innate immune-related pathways such as the Toll-like receptor pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway and JAK-STAT signaling pathway, and this might play a major role in the anti-inflammatory response. Further understanding of the roles played by these miRNAs in influenza virus infection will provide new insights into host-pathogen interactions.
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This study was supported by the College of Veterinary Medicine of South China Agricultural University and University-Based Key Laboratory of Preventive Veterinary Medicine of Foshan University in Guangdong Province.
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L. Huang and J. Ma contributed equally.
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Huang, L., Ma, J., Sun, Y. et al. Altered splenic miRNA expression profile in H1N1 swine influenza. Arch Virol 160, 979–985 (2015). https://doi.org/10.1007/s00705-015-2351-0
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DOI: https://doi.org/10.1007/s00705-015-2351-0