Summary
We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003–2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1–13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
References
L Alexander E Weiskopf TC Greenough NC Gaddis MR Auerbach MH Malim SJ O’Brien BD Walker JL Sullivan RC Desrosiers (2000) ArticleTitleUnusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection J Virol 74 4361–4376 Occurrence Handle10756051 Occurrence Handle10.1128/JVI.74.9.4361-4376.2000 Occurrence Handle1:CAS:528:DC%2BD3cXislGqsrc%3D
G Bleiber S Peters R Martinez D Cmarko P Meylan A Telenti (2004) ArticleTitleThe central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14–I31) is dispensable for the virus in vitro J Gen Virol 85 921–927 Occurrence Handle15039534 Occurrence Handle10.1099/vir.0.19576-0 Occurrence Handle1:CAS:528:DC%2BD2cXivF2mtbg%3D
DG Demirov JM Orenstein EO Freed (2002) ArticleTitleThe late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner J Virol 76 105–117 Occurrence Handle11739676 Occurrence Handle10.1128/JVI.76.1.105-117.2002 Occurrence Handle1:CAS:528:DC%2BD3MXptFCmsrg%3D
Eric SB, Mika OS, Francine EM (1995) Sequencing Primers for HIV-1. The Human Retroviruses and AIDS 1995 Compendium, III–15
EO Freed (2001) ArticleTitleHIV-1 replication Somat Cell Mol Genet 26 13–33 Occurrence Handle12465460 Occurrence Handle10.1023/A:1021070512287 Occurrence Handle1:STN:280:DC%2BD38jgsVartQ%3D%3D
Gallego O, DE Mendoza C, Corral A, Soriano V (2002) Changes at the HIV-1 p6 protein among antiretroviral-naive and pre-treated patients. Abstr. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Madrid, Spain 2002. Abstract No: H-2053
I Le Blanc MC Prevost MC Dokhelar AR Rosenberg (2002) ArticleTitleThe PPPY motif of human T-cell leukemia virus type 1 Gag protein is required early in the budding process J Virol 76 10024–10029 Occurrence Handle12208980 Occurrence Handle10.1128/JVI.76.19.10024-10029.2002 Occurrence Handle1:CAS:528:DC%2BD38XntFGktro%3D
N Marlowe T Flys J Hackett SuffixJr M Schumaker JB Jackson SH Eshleman (2004) ArticleTitleAnalysis of insertions and deletions in the gag p6 region of diverse HIV type 1 strains AIDS Res Hum Retrovir 20 1119–1125 Occurrence Handle15585104 Occurrence Handle10.1089/aid.2004.20.1119 Occurrence Handle1:CAS:528:DC%2BD2cXptVOhsbw%3D
J Martin-Serrano PD Bieniasz (2003) ArticleTitleA bipartite late-budding domain in human immunodeficiency virus type 1 J Virol 77 12373–12377 Occurrence Handle14581576 Occurrence Handle10.1128/JVI.77.22.12373-12377.2003 Occurrence Handle1:CAS:528:DC%2BD3sXovVantbo%3D
S Peters M Munoz S Yerly V Sanchez-Merino C Lopez-Galindez L Perrin B Larder D Cmarko S Fakan P Meylan A Telenti (2001) ArticleTitleResistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein J Virol 75 9644–9653 Occurrence Handle11559796 Occurrence Handle10.1128/JVI.75.20.9644-9653.2001 Occurrence Handle1:CAS:528:DC%2BD3MXnt1Ghtbw%3D
S Piyasirisilp FE McCutchan JK Carr E Sanders-Buell W Liu J Chen R Wagner H Wolf Y Shao S Lai C Beyrer XF Yu (2000) ArticleTitleA recent outbreak of human immunodeficiency virus type infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant J Virol 74 11286–11295 Occurrence Handle11070028 Occurrence Handle10.1128/JVI.74.23.11286-11295.2000 Occurrence Handle1:CAS:528:DC%2BD3MXitFWmu74%3D
B Strack A Calistri S Craig E Popova HG Gottlinger (2003) ArticleTitleAIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding Cell 114 689–699 Occurrence Handle14505569 Occurrence Handle10.1016/S0092-8674(03)00653-6 Occurrence Handle1:CAS:528:DC%2BD3sXnslKisb4%3D
L Su M Graf Y Zhang H von Briesen H Xing J Kostler H Melzl H Wolf Y Shao R Wagner (2000) ArticleTitleCharacterization of a virtually full-Length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B) recombinant strain in China J Virol 74 11367–11376 Occurrence Handle11070037 Occurrence Handle10.1128/JVI.74.23.11367-11376.2000 Occurrence Handle1:CAS:528:DC%2BD3MXitFWmu7c%3D
Author information
Authors and Affiliations
Additional information
YanHui Song and ZheFeng Meng contributed equally to this paper.
Rights and permissions
About this article
Cite this article
Song, Y., Meng, Z., Xing, H. et al. Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6. Arch Virol 152, 1553–1558 (2007). https://doi.org/10.1007/s00705-007-0973-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00705-007-0973-6