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Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis

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Summary.

We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 30 patients with sporadic amyotrophic lateral sclerosis (SALS) and 78 matched controls. The mean CSF and serum vitamin E levels did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal versus bulbar) of SALS. CSF alpha-tocopherol levels did not correlate with age, age at onset, and duration of the disease. These results suggest that CSF and serum alpha-tocopherol concentrations are unrelated with the risk for ALS.

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Authors and Affiliations

  1. Departments of Biochemistry, and, , , , ,

    F. de Bustos & J. Arenas

  2. Neurology, Hospital Universitario Doce de Octubre,, , , , ,

    J. A. Molina, J. Esteban & C. Gómez-Escalonilla

  3. Section of Neurology, Hospital "Príncipe de Asturias", University of Alcalá de Henares,, , , , ,

    F. J. Jiménez-Jiménez, M. Zurdo, M. Ortí-Pareja & A. Tallón-Barranco

  4. Service of Neurology, Hospital Universitario San Carlos, and, , , , ,

    A. Guerrero-Sola & C. Ramírez-Ramos

  5. Department of Medicine, University Complutense, Madrid, Spain, , , , , , ES

    R. Enríquez de Salamanca

Authors
  1. F. de Bustos
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  2. F. J. Jiménez-Jiménez
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  3. J. A. Molina
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  4. J. Esteban
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  5. A. Guerrero-Sola
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  6. M. Zurdo
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  7. M. Ortí-Pareja
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  8. A. Tallón-Barranco
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  9. C. Gómez-Escalonilla
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  10. C. Ramírez-Ramos
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  11. J. Arenas
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  12. R. Enríquez de Salamanca
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Additional information

Received February 25, 1998; accepted April 23, 1998

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de Bustos, F., Jiménez-Jiménez, F., Molina, J. et al. Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis. J Neural Transm 105, 703–708 (1998). https://doi.org/10.1007/s007020050089

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  • DOI: https://doi.org/10.1007/s007020050089

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