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Effects of resveratrol on incisional wound healing in rats

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Abstract

Purpose

The objective of this study was to investigate the effect of resveratrol on the healing process after midline laparotomy in rats.

Methods

The study was performed on adult female Wistar-Albino rats. The study group was orally administered 0.5 mg/kg resveratrol once a day for 7 days before the operation until 12 h before surgery and then the treatment was maintained throughout the study. Each rat was anesthetized, and a 4-cm midline laparotomy was performed. Ten animals in each group were sacrificed on postoperative days 7, and 14. A tensile strength analysis was performed, hydroxyproline levels were measured, and the abdominal incision wounds were examined histologically.

Results

Resveratrol administration significantly increased the tensile strength of the abdominal fascia, and increased the hydroxyproline levels on postoperative day 14. The acute inflammation scores, collagen deposition scores and the neovascularization scores on postoperative days 7 and 14 were found to be significantly higher in the resveratrol treatment group compared to the control group. The amount of granulation tissue and the fibroblast maturation scores were found to be significantly higher only on postoperative day 14 in the treatment group compared to the control group.

Conclusion

Our findings show that resveratrol may have a beneficial effect on incisional wound healing.

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Conflict of interest

The authors of this article have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of General Surgery, The School of Medicine, Balikesir University, Ataturk mah Bandirma Cad 47/6, Balikesir, Turkey

    Ismail Yaman & Hayrullah Derici

  2. Department of General Surgery, Karsiyaka State Hospital, Izmir, Turkey

    Cemal Kara

  3. Department of General Surgery, Ataturk Training and Research Hospital, Izmir, Turkey

    Erdinc Kamer

  4. Department of Pathology, Dr. Behcet Uz Children’s Hospital, Izmir, Turkey

    Gulden Diniz & Ragip Ortac

  5. Research Laboratory of Biochemistry, Department of Biochemistry, The School of Medicine, Dokuz Eylul University, Izmir, Turkey

    Oya Sayin

Authors
  1. Ismail Yaman
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  2. Hayrullah Derici
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  3. Cemal Kara
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  4. Erdinc Kamer
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  5. Gulden Diniz
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  7. Oya Sayin
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Correspondence to Ismail Yaman.

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Yaman, I., Derici, H., Kara, C. et al. Effects of resveratrol on incisional wound healing in rats. Surg Today 43, 1433–1438 (2013). https://doi.org/10.1007/s00595-012-0455-7

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  • DOI: https://doi.org/10.1007/s00595-012-0455-7

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