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Fibrinolytic system of the armadillo Chaetophractus villosus (Xenarthra, Dasypodidae)

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Abstract

The fibrinolytic mechanism in the armadillo Chaetophractus villosus (Mammalia, Xenarthra, Dasypodidae) quite unknown until now was studied. Results were compared with those corresponding to healthy adult human beings. Whole blood lysis time and diluted blood lysis time were not detectable in armadillos. Euglobulin clot lysis time and plasminogen activity (Plg) were lower than in healthy humans. We established the presence of the fibrinolytic system in Ch. villosus through the measurement of fibrin fibrinogen degradation products. The activity of the plasminogen activator inhibitor was two to four times greater than in healthy humans. The activity of the alpha 2 anti-plasmin (α2AP) was similar and displaced toward lower values. The Plg/α2AP relation was lower. The results obtained suggest that Ch. villosus has a hypercoagulable and hypofibrinolytic profile. Our findings are not only the first contribution to elucidate the physiology of the fibrinolytic system in Xenarthra but also contribute to develop an animal model for studies in haemostasis and thrombosis.

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Acknowledgments

This study was supported by Secretaría General de Ciencia y Tecnología, Universidad Nacional del Sur (SGCyT-UNS), Project 24/B122 and Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), BID 1728/OC PICTR 074/03, Argentina.

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Authors and Affiliations

  1. Cátedra de Fisiología Animal, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina

    Juan Tentoni & Emma Beatriz Casanave

  2. Cátedra de Análisis Clínicos II, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina

    Nélida Nora Polini

  3. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

    Emma Beatriz Casanave

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  1. Juan Tentoni
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  2. Nélida Nora Polini
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  3. Emma Beatriz Casanave
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Correspondence to Emma Beatriz Casanave.

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Tentoni, J., Polini, N.N. & Casanave, E.B. Fibrinolytic system of the armadillo Chaetophractus villosus (Xenarthra, Dasypodidae). Comp Clin Pathol 17, 193–196 (2008). https://doi.org/10.1007/s00580-008-0721-7

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  • DOI: https://doi.org/10.1007/s00580-008-0721-7

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