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Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study

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Abstract

Study on the normal saline vs povidone–iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al. 13:554–558, (2005)]. The multivariable analysis of larger cohort of 148 patients compliant with the original study protocol confirmed female gender to be an independent risk factor and predictor for OM. The HD-L-PAM (200 mg/m2) conditioning regimen revealed to be more toxic compared to BEAM as for incidence of OM grades 3–4 World Health Organization score. Body mass index, age, mouthwash solution used, and CD34+ cell number in the autologous graft were verified not to have an impact on OM incidence in this group of patients.

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References

  1. Vokurka S, Bystricka E, Koza V et al (2005) The comparative effects of povidone–iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT—results of a randomized multicentre study. Support Care Cancer 13:554–558

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Acknowledgements

We highly acknowledge the assistance of K. Steinerova, M.D., F.Šefrna, RNDr., I. Chvojková, V. Kaslová (Plzen), J. Vítková (Olomouc), J. Maslová (Hradec Králové), P. Horvathová, V. Jarolíková, R. Micheliová (Bratislava), J. Bocková (Kosice), A. Kalocayová, E. Karliková, S. Kerestenyová, S. Gyurkyová and S. Statianová (Bánská Bystrica).

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Authors and Affiliations

  1. Department of Haemato-Oncology, University Hospital, Alej Svobody 80, Plzen, 304 60, Czech Republic

    Samuel Vokurka, Eva Bystrická & Vladimír Koza

  2. Department of Haemato-Oncology, University Hospital Olomouc, Olomouc, Czech Republic

    Jana Scudlová

  3. Department of Clinical Haematology, University Hospital, Hradec Kralove, Czech Republic

    Vladislava Pavlicová

  4. Department of Haematology and Transfusion Medicine, University Hospital, Bratislava, Slovak Republic

    Dana Valentová

  5. Department of Haematology, University Hospital, Kosice, Slovak Republic

    Maria Visokaiová

  6. Department of Haematology, F.D. Roosevelt Hospital, Banska Bystrica, Slovak Republic

    Lubica Misaniová

Authors
  1. Samuel Vokurka
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  2. Eva Bystrická
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  3. Vladimír Koza
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  4. Jana Scudlová
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  5. Vladislava Pavlicová
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  6. Dana Valentová
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  7. Maria Visokaiová
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  8. Lubica Misaniová
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Corresponding author

Correspondence to Samuel Vokurka.

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Vokurka, S., Bystrická, E., Koza, V. et al. Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study. Support Care Cancer 14, 974–976 (2006). https://doi.org/10.1007/s00520-006-0031-z

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  • DOI: https://doi.org/10.1007/s00520-006-0031-z

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