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Transkranielle Magnetstimulation und Motorkortexstimulation bei neuropathischen Schmerzen

Transcranial magnetic stimulation and motor cortex stimulation in neuropathic pain

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Zusammenfassung

Die nichtinvasive und invasive Motorkortexstimulation können therapierefraktäre neuropathische Schmerzen verbessern. Mit der hochfrequenten repetitiven transkraniellen Magnetstimulation (rTMS) des kontralateralen Motorkortex können kurzzeitige therapeutische Effekte erzielt und der Effekt einer epiduralen Motorkortexstimulation (MCS) vorhergesagt werden. Der vorliegende Artikel fasst die aktuellen Erkenntnisse zu Anwendung, Mechanismen und Therapieeffekten der kortikalen Stimulation bei neuropathischen Schmerzen zusammen.

Abstract

Non-invasive and invasive cortical stimulation allows the modulation of therapy-refractory neuropathic pain. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the contralateral motor cortex yields therapeutic effects at short-term and predicts the benefits of epidural motor cortex stimulation (MCS). The present article summarizes the findings on application, mechanisms and therapeutic effects of cortical stimulation in neuropathic pain.

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Danksagung

Die vorliegende Arbeit wurde durch ein Stipendium der Prof. Schmidtmann-Stiftung in Marburg unterstützt.

Interessenkonflikt

Der korrespondierende Autor weist für sich und seine Koautoren auf folgende Beziehung hin: Der korrespondierende Autor stellte auf Einladung der Firma Nexstim einen Teil dieses Beitrags beim 3. NBS-Symposium am 22.10.2011 in Berlin vor.

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Authors and Affiliations

  1. Faculté de Médecine, EA 4391, Université Paris-Est Créteil, Créteil, Frankreich

    V. Mylius, S.S. Ayache & J.P. Lefaucheur

  2. Klinik für Neurologie, Philipps-Universität Marburg, Baldingerstr., 35043, Marburg, Deutschland

    V. Mylius, M. Teepker, F. Rosenow & W.H. Oertel

  3. Service de Physiologie – Explorations Fonctionnelles, Hôpital Henri Mondor, Assistance Publique – Hôpitaux de Paris, Créteil, Frankreich

    S.S. Ayache & J.P. Lefaucheur

  4. Abteilung für Neurologie, Ammerland-Klinik, Westerstede, Deutschland

    M. Teepker

  5. Klinik für Neurochirurgie, Philipps-Universität Marburg, Marburg, Deutschland

    C. Kappus & C. Nimsky

  6. Klinik für Neurochirurgie, Justus-Liebig-Universität Gießen, Gießen, Deutschland

    M. Kolodziej

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  1. V. Mylius
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  2. S.S. Ayache
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  3. M. Teepker
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  9. J.P. Lefaucheur
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Correspondence to V. Mylius.

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Mylius, V., Ayache, S., Teepker, M. et al. Transkranielle Magnetstimulation und Motorkortexstimulation bei neuropathischen Schmerzen. Schmerz 26, 655–660 (2012). https://doi.org/10.1007/s00482-012-1243-4

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  • DOI: https://doi.org/10.1007/s00482-012-1243-4

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