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Bone impairment in primary hyperoxaluria: a review

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Abstract

Deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria (PH). Since the bone compartment can store massive amounts of oxalate, patients present with recurrent low-trauma fractures, bone deformations, severe bone pains, and specific oxalate osteopathy on X-ray. Bone biopsy from the iliac crest displays specific features such as oxalate crystals surrounded by a granulomatous reaction corresponding to an invasion of bone surface by macrophages. The objective of this manuscript is therefore to provide an overview of bone impairment in PH, by reviewing the current literature on bone and dental symptoms as well as imaging techniques used for assessing bone disease.

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Disclosures

None of the authors has direct conflicts of interest concerning the present manuscript.

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Authors and Affiliations

  1. Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, 69500, Bron, France

    Justine Bacchetta & Pierre Cochat

  2. INSERM, UMR 1033, 69008, Lyon, France

    Justine Bacchetta & Georges Boivin

  3. Université de Lyon, 69008, Lyon, France

    Justine Bacchetta, Georges Boivin & Pierre Cochat

  4. Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Boulevard Pinel, 69677, Bron cedex, France

    Justine Bacchetta

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  1. Justine Bacchetta
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  3. Pierre Cochat
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Correspondence to Justine Bacchetta.

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Bacchetta, J., Boivin, G. & Cochat, P. Bone impairment in primary hyperoxaluria: a review. Pediatr Nephrol 31, 1–6 (2016). https://doi.org/10.1007/s00467-015-3048-z

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  • DOI: https://doi.org/10.1007/s00467-015-3048-z

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