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Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery

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Abstract

Background

Recent data indicate that pneumoperitoneal carbondioxide (CO2) insufflation impairs hepatic macro- and microcirculation. Whether dopamine and endothelin-1 (ET-1) antagonists might restore liver blood during laparoscopic surgery has not yet been investigated.

Methods

For this study, 30 male WAG/Rij rats were randomized into two groups to obtain pneumoperitoneum with CO2 (n=15) or helium (n=15). All the animals were implanted with a polyethylene-50 cannula into the right vena jugularis and a Doppler ultrasound flow probe around the portal vein. In each group, the rats were administered dopamine (n=5); JKC-10, JKC-301, which is a selective endothelin-1 (ET-1) antagonist (n=5), or sodium chloride as a control (n=5). Portal blood flow was measured during intraabdominal pressures 2 to 12 mmHg. Data were analyzed using the Kruskal-Wallis h-test.

Results

The application of dopamine and ET-1 antagonists significantly improved portal blood flow over that of the control animals (p<0.05). No significant differences were found between CO2 and helium insufflation (p>0.05).

Conclusions

Dopamine and ET-1 antagonism restore portal blood flow during laparoscopic surgery independantly of the insufflation gas. Whether improved hepatic perfusion might have beneficial effects on liver function needs further investigation.

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Authors and Affiliations

  1. Department of General and Vascular Surgery, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany

    Z. G. Kim, E. Sanli, L. Brinkmann, M. Lorenz & C. N. Gutt

Authors
  1. Z. G. Kim
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  2. E. Sanli
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  3. L. Brinkmann
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  4. M. Lorenz
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  5. C. N. Gutt
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Online publication: 23 May 2002

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Kim, Z.G., Sanli, E., Brinkmann, L. et al. Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery. Surg Endosc 16, 1292–1296 (2002). https://doi.org/10.1007/s00464-001-9208-1

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  • DOI: https://doi.org/10.1007/s00464-001-9208-1

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