Abstract
The present study investigated the pathogenesis of Blastocystis hominis by intramuscular injection of the organism into experimental mice. A total of 27 naïve BALB/c mice aged 6–8 weeks were injected in the leg muscle with axenic culture isolate B of B. hominis. Histological examination at different times revealed that B. hominis could produce a severe inflammatory reaction and myonecrosis. Most changes were observed at 6 h after injection and for up to 2–3 days. By 2 weeks the muscle had regained normal histology. There was infiltration of polymorphonuclear leukocytes (PML) into the injection site, indicating that B. hominis had a strong chemoattractant activity for PML.
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Received: 11 August 1997 / Accepted: 12 November 1997
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Moe, K., Singh, M., Gopalakrishnakone, P. et al. Cytopathic effect of Blastocystis hominis after intramuscular inoculation into laboratory mice. Parasitol Res 84, 450–454 (1998). https://doi.org/10.1007/s004360050428
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DOI: https://doi.org/10.1007/s004360050428