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In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum

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Abstract

Malaria is one of the most prevalent infectious diseases in the world. Treatment for malaria is commonly inadequate due to the lack of quality assured effective drugs. The effectiveness of these drugs is declining at an ever accelerating rate, with consequent increase in malaria related morbidity and mortality. The newest antiplasmodial drug from plants is needed to overcome this problem. Numerous mangroves and mangal associates are used as folklore medicine to treat various human diseases. The mangrove plant species are a good source of potential bioactive entities which exhibits many therapeutic properties. The present study was carried out to test the antiplasmodial activity of five mangrove plant species distributed along the South East coast of India. Bruguiera cylindrica, Ceriops decandra, Lumnitzera racemosa, Rhizophora apiculata, and Rhizophora mucronata mangrove plant extracts exhibited in vitro antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum. Of which, the ethanolic bark extract of R. mucronata exhibited high antiplasmodial activity (IC50 = 62.18 μg.ml−1). Statistical analysis reveals that, significant antiplasmodial activity (P < 0.05) was observed between the concentrations and time of exposure. The chemical injury to erythrocytes was also carried out and it shows that no morphological differences in erythrocytes by the ethanolic extract of mangrove plants after 48 h of incubation. The screening for phytochemical constituents in the mangrove plants were carried out and it reveals that, the presence of alkaloids, triterpenes, flavonoids, tannins, catachin, anthroquinone, phenols, sugars, and proteins. This study shows that the mangrove plants had a source of lead compounds for the development of new drugs for the treatment of malaria.

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Acknowledgments

The authors are thankful to the authorities of Alagappa University for providing required facilities and also to Indian Council of Medical Research, New Delhi for financial assistance.

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  1. School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, , Tamil Nadu, India

    Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi & Murugesan Gnanadesigan

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  1. Sundaram Ravikumar
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  2. Samuel Jacob Inbaneson
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  3. Palavesam Suganthi
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  4. Murugesan Gnanadesigan
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Correspondence to Sundaram Ravikumar.

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Ravikumar, S., Jacob Inbaneson, S., Suganthi, P. et al. In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum . Parasitol Res 108, 873–878 (2011). https://doi.org/10.1007/s00436-010-2128-z

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