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Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism

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Abstract

Hypoparathyroidism is one of the recognized causes of late-onset neonatal hypocalcemia. Maternal hypercalcemic hyperparathyroidism has been shown to suppress fetal parathyroid glands, causing transient neonatal hypoparathyroidism. We report two siblings (6 years apart) with transient hypoparathyroidism presented with hypocalcemic seizures during the first 2 weeks of life. Subsequent investigation revealed an unrecognized normocalcemic hyperparathyroidism with nephrocalcinosis in the mother. Maternal hyperparathyroidism was caused by two parathyroid adenomas. In conclusion, our report highlights the importance of careful evaluation of neonatal hypoparathyroidism in uncovering an unrecognized, asymptomatic hyperparathyroidism in the mother.

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Abbreviations

iPTH:

intact parathyroid hormone

PTH:

parathyroid hormone

ALP:

alkaline phosphatase

Ca:

calcium

P:

phosphorus

Cr:

creatinine

1α-OHD:

1α-hydroxyvitamin D

CaCO3 :

calcium carbonate

Al(OH)3 :

aluminium hydroxide

CBC:

complete blood count

ND:

not determined

References

  1. Beattie GC, Ravi NR, Lewis M, Williams H, Blair AW, Campbell IW, Browning GG (2000) Rare presentation of maternal primary hyperparathyroidism. BMJ 321:223–224

    Article  PubMed  CAS  Google Scholar 

  2. Bucht E, Eklund A, Toss G, Lewensohn R, Granberg B, Sjostedt U, Eddeland R, Torring O (1992) Parathyroid hormone-related peptide, measured by a midmolecule radioimmunoassay, in various hypercalcaemic and normocalcaemic conditions. Acta Endocrinol (Copenh) 127:294–300

    CAS  Google Scholar 

  3. Cemeroglu AP, Bober E, Buyukgebiz A (2001) Prolonged hypocalcemia in a 2-month-old boy unmasking maternal diagnosis of primary hyperparathyroidism. J Pediatr Endocrinol Metab 14:785–787

    PubMed  CAS  Google Scholar 

  4. Diamond FB, Root AW (2002) Disorders of calcium metabolism in the newborn and infant. In: Sperling MA (ed) Pediatric Endocrinology. Saunders, Philadelphia, pp 97–110

    Google Scholar 

  5. Furioli J, Wipff P (1990) Hypocalcemic seizures in two newborn siblings revealing hyperparathyroidism in the mother. Ann Pediatr (Paris) 37:451–453

    CAS  Google Scholar 

  6. Hagstrom E, Lundgren E, Rastad J, Hellman P (2006) Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening. Eur J Endocrinol 155:33–39

    Article  PubMed  Google Scholar 

  7. Hamidi S, Soltani A, Hedayat A, Kamalian N (2006) Primary hyperparathyroidism: a review of 177 cases. Med Sci Monit 12:CR86–CR89

    PubMed  Google Scholar 

  8. Hsieh YY, Chang CC, Tsai HD, Yang TC, Chiu TH, Tsai CH (1998) Primary hyperparathyroidism in pregnancy—report of 3 cases. Arch Gynecol Obstet 261:209–214

    Article  PubMed  CAS  Google Scholar 

  9. Ip P (2003) Neonatal convulsion revealing maternal hyperparathyroidism: an unusual case of late neonatal hypoparathyroidism. Arch Gynecol Obstet 268:227–229

    Article  PubMed  Google Scholar 

  10. Kovacs CS, Kronenberg HM (1997) Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 18:832–872

    Article  PubMed  CAS  Google Scholar 

  11. Marx SJ (2000) Hyperparathyroid and hypoparathyroid disorders. N Engl J Med 343:1863–1875

    Article  PubMed  CAS  Google Scholar 

  12. Pieringer H, Hatzl-Griesenhofer M, Shebl O, Wiesinger-Eidenberger G, Maschek W, Biesenbach G (2007) Hypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidism. Wien Klin Wochenschr 119:129–131

    Article  PubMed  Google Scholar 

  13. Silverberg SJ, Bilezikian JP (1996) Evaluation and management of primary hyperparathyroidism. J Clin Endocrinol Metab 81:2036–2040

    Article  PubMed  CAS  Google Scholar 

  14. Tutunculer F, Gunoz H (2005) Neonatal hypocalcemia due to asymptomatic maternal primary hyperparathyroidism. Indian Pediatr 42:294–295

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, 10400, Thailand

    Preamrudee Poomthavorn & Pat Mahachoklertwattana

  2. Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, 10400, Thailand

    Boonsong Ongphiphadhanakul

Authors
  1. Preamrudee Poomthavorn
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  2. Boonsong Ongphiphadhanakul
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  3. Pat Mahachoklertwattana
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Correspondence to Pat Mahachoklertwattana.

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Poomthavorn, P., Ongphiphadhanakul, B. & Mahachoklertwattana, P. Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism. Eur J Pediatr 167, 431–434 (2008). https://doi.org/10.1007/s00431-007-0528-6

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  • DOI: https://doi.org/10.1007/s00431-007-0528-6

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