Abstract
Recent research suggests the anterior and posterior hippocampus form part of two distinct functional neural networks. Here we investigate the structural underpinnings of this functional connectivity difference using diffusion-weighted imaging-based parcellation. Using this technique, we substantiated that the hippocampus can be parcellated into distinct anterior and posterior segments. These structurally defined segments did indeed show different patterns of resting state functional connectivity, in that the anterior segment showed greater connectivity with temporal and orbitofrontal cortex, whereas the posterior segment was more highly connected to medial and lateral parietal cortex. Furthermore, we showed that the posterior hippocampal connectivity to memory processing regions, including the dorsolateral prefrontal cortex, parahippocampal, inferior temporal and fusiform gyri and the precuneus, predicted interindividual relational memory performance. These findings provide important support for the integration of structural and functional connectivity in understanding the brain networks underlying episodic memory.
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Acknowledgments
The authors would like to thank Irene Giannoylis, Keith Ta and Eugene Hlasny for their help in fMRI data collection. The authors declare no competing financial interests. This work was supported by Grants from the Canadian Institute of Health Research (CIHR; Grant Number 97891 to M.P.M; CIHR fellowship to M.M) and the James S. McDonnell Foundation (JSMF # 22002055 to M.P.M).
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A. Adnan, A. Barnett and M. Moayedi contributed equally to this work and share first authorship.
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Adnan, A., Barnett, A., Moayedi, M. et al. Distinct hippocampal functional networks revealed by tractography-based parcellation. Brain Struct Funct 221, 2999–3012 (2016). https://doi.org/10.1007/s00429-015-1084-x
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DOI: https://doi.org/10.1007/s00429-015-1084-x