Abstract
Marine algae are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against other settling organisms. These active metabolites, also known as biogenic compounds, produced by several species of marine macro- and micro-algae, have antibacterial, antialgal, antimacrofouling and antifungal properties, which are effective in the prevention of biofouling, and have other likely uses, e.g. in therapeutics. The isolated substances with potent antifouling activity belong to groups of fatty acids, lipopeptides, amides, alkaloids, terpenoids, lactones, pyrroles and steroids. These biogenic compounds have the potential to be produced commercially using metabolic engineering techniques. Therefore, isolation of biogenic compounds and determination of their structure could provide leads for future development of, for example, environmentally friendly antifouling paints. This paper mainly discusses the successes of such research, and the future applications in the context of understanding the systems biology of micro-algae and cyanobacteria.
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Abbreviations
- AHL:
-
Acylated homoserine lactone
- TBT:
-
Tributyl tin
References
Abarzua S, Jakubowski S (1995) Biotechnological investigation for the prevention of biofouling. I. Biological and biochemical principles for the prevention of biofouling. Mar Ecol Prog Ser 123:301–312
Abarzua S, Jakubowski S (1996) Verwendung biogener Wirkstoffe aus dem Cyanobacterium Scytonema hofmanni und de Gemeinen Seestern Asterias rubens als naturliche Antifoulingwirkstoffe. German Patent No. IP Hkl A01N63/02, DE 196 46 324 Al
Abarzua S, Jakubowski S, Eckert S, Fuchs P (1999) Biotechnological investigation for the prevention of marine biofouling II. Blue-green algae as potential producers of biogenic agents for the growth inhibition of microfouling organisms. Bot Mar 42:459–465
Abe M, Inoue D, Matsunaga K, Ohizumi Y, Ueda H, Asano T, Murakami M, Sato Y (2002) Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells. J Cell Physiol 190:109–116
Ali MS, Saleem M, Yamdagni R, Ali MA (2002) Steroid and antibacterial steroidal glycosides from marine green alga Codium iyengarii Borgesen. Nat Prod Lett 16:407–413
Anisul A, DeNys R, Steinberg P (2003) The effects of low surface energy coatings on the settlement and behavioural responses of the cyprid larvae of barnacle Balanus amphitrite Darwin. Biofouling [Suppl] 19:105–110
Armstrong E, Boyd KG, Burgess JG (2000) Prevention of marine biofouling using natural compounds from marine organisms. Biotechnol Annu Rev 6:221–241
Armstrong E, Yan L, Boyd KG, Wright PC, Burgess JG (2001) The symbiotic role of marine microbes on living surfaces. Hydrobiologia 461:37–40
Badria FA, Guirguis AN, El-Naggar WA (1997) Antibacterial and antifungal agents from Egyptian marine organisms. Int J Pharm 35:284–287
Baghi SN, Palod A, Chauhan VS (1990) Algicidal properties of a bloom-forming blue-green alga Oscillatoria spec. J Basic Microbiol 30:21–29
Bailey JE (1991) Towards a science of metabolic engineering. Science 252:1668–1675
Bakus GJ, Targett NM, Schulte B (1986) Chemical ecology of marine organisms: an overview. J Chem Eco 12:951–987
Banker R, Carmeli S (1998) Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaformae var tenue. J Nat Prod 61:1248–1251
Barahona LF, Rorrer GL (2003) Isolation of halogenated monoterpenes from bioreactor-cultured microplantlets of the macrophytic red algae Ochtodes secundiramea and Portieria hornemannii. J Nat Prod 66:743–751
Bassler BL (1999) How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr Opin Microbiol 2:582–587
Bernan VS, Greenstein M, Maiese WM (1997) Marine micro-organisms as a source of new natural products. Adv Appl Microbiol 43:57–89
Bernard P, Pesando D (1989) Antibacterial and antifungal activity of extracts from the rhizomes of the Mediterranean seagrass Posidonia oceanica (L.) Delile. Bot Mar 32:85–88
Bhosale SH, Nagle VL, Jagtap TG (2002) Antifouling potential of some marine organisms from India against species of Bacillus and Pseudomonas. Mar Biotechnol 4:111–118
Blanke SR, Yang R (2002) Identification of novel genes essential for bacterial survival during environmental Biofouling. http://www.eih.uh.edu/publications/01annrep/blanke.htm. Cited 2002
Bloor S, England RR (1991) Elucidation and optimization of the medium constituents controlling antibiotic production by the cyanobacterium Nostoc muscorum. Enzyme Microb Tech 13:76–81
Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR (2003) Marine natural products. Nat Prod Rep 20:1–48
Böhm GA, Pfleiderer W, Boger P, Scherer S (1995) Structure of a novel oligosaccharide-mycosporine-amino acid ultraviolet A/B sunscreen pigment from the terrestrial cyanobacterium Nostoc commune. J Biol Chem 270:8536–8539
Bonjouklian R, Smitka TA, Doolin LE, Molloy RM, Debono M, Shaffer SA (1991) Tjipanazoles, new antifungal agents from the blue green algae Tolypothrix tjipanasensis. Tetrahedron 47:7739–7750
Borchardt SA, Allain EJ, Michels JJ, Stearns GW, Kelly RF, McCoy WF (2001) Reaction of acylated homoserine lactone bacterial signalling molecules with oxidized halogen antimicrobials. Appl Environ Microbiol 67:3174–3179
Borowitzka MA (1995) Microalgae as sources of pharmaceuticals and other biologically active compounds. J Appl Phycol 7:3–15
Boxall ABA, Comber SD, Conrad AU, Howcroft J, Zaman N (2000) Inputs, monitoring and fate modelling of antifouling biocides in UK estuaries. Mar Pollut Bull 40:898–905
Brõzel VS, Strydom GM, Cloete TEE (1995) A method for the study of de novo protein synthesis in Pseudomonas aeruginosa after attachment. Biofouling 8:195–210
Burgess JG, Jordan EM, Bregu M, Mearns-Spragg A, Boyd KG (1999) Microbial antagonism: a neglected avenue of natural products research. J Biotechnol 70:27–32
Burgess JG, Boyd KG, Armstrong E, Jiang Z, Yan L, Berggren M, May U, Pisacane T, Grammo A, Adams DR (2003) The development of a marine natural product-based antifouling paint. Biofouling 19:197–205
Burja AM, Banaigs B, Abou-Mansour E, Burgess JG, Wright PC (2001) Marine cyanobacteria—a prolific source of natural products. Tetrahedron 57:9347–9377
Burja AM, Dhamwichukorn S, Wright PC (2003) Cyanobacterial postgenomic research and systems biology. Trends Biotechnol 21:504–11
Burridge TR, Lavery T, Lam PKS (1995) Effects of tributyltin and formaldehyde on the germination and growth of Phyllospora comosa (Labillardiere) C. Agardh (Phaeophyta: Fucales) Bull Environ Contam Toxicol 55:525–532
Caccamese S, Azzolina R, Furnari G, Cormai M, Grasso S (1981) Antimicrobial and antiviral activities of some marine algae from Eastern Sicily. Bot Mar 14:365–367
Caccamese S, Toscano RM, Furnari G, Coraci M (1985) Antimicrobial activities of red and brown algae from Southern Italy coast. Bot Mar 28:505–507
Callow ME (1996) Ship-fouling: the problem and methods of control. Biodeter Abstr 10:411–421
Callow ME, Callow JE (2002) Marine biofouling: a sticky problem. Biologist 49:4–10
Cannell RJP, Owsianka A, Walker JM (1988) Results of a large-scale screening programme to detect antibacterial activity from fresh water algae. Br Phycol J 23:41–44
Carlozzi P (2003) Dilution of solar radiation through “culture” lamination in photobioreactor rows facing south–north: a way to improve the efficiency of light utilization by cyanobacteria (Arthrospira platensis). Biotechnol Bioeng 81:305–315
Carmichael WW, Mahmood NA, Hyde EG (1990) Natural toxins from cyanobacteria (blue-green algae). In: Hall S, Strichartz G (eds) Marine toxins: origin, structure and molecular pharmacology. ACS symposium series, vol 418. American Chemical Society, Washington DC, pp 87–106
Caron DA, Seiburth JMcN (1981) Disruption of the primary fouling sequence on fibre glass-reinforced plastic submerged in the marine environment. Appl Environ Microbiol 41:268–273
Carte BK (1996) Biomedical potential of marine natural products: marine organisms are yielding novel molecules for use in basic research and medical applications. Bioscience 46:271–286
Characklis WG (1981) Fouling biofilm development: a process analysis. Biotech Bioeng 23:1923–1960
Charles SV, Sivalingam PM (1994) Antibacterial activity of the tropical Chlorophyta Ulva reticulata Forsskal. Second Asia–Pacific conference on algal biotechnology, Singapore
Chetsumon A, Umeda F, Maeda I, Yagi K, Mizoguchi T, Miura Y (1998) Broad spectrum and mode of action of an antibiotic produced by Scytonema sp. TISTR 8208 in a seaweed-type bioreactor. Appl Biochem Biotechnol 70–72:249–256
Clare AS (1996) Marine natural product antifoulants: status and potential. Biofouling 9:211–229
Clayton MN, King RJ (1990) Biology of marine plants. Longman Chesire, Melbourne
Corpe W (1970) Periphytic marine bacteria and the formation of the microbial films on solid surfaces. In: Colwell R, Morita R (eds) Effect of the ocean environment on microbial activities. University Park Press, New York, pp 397–417
Costerton JW (1995) Overview of microbial biofilms. J Ind Microbiol 15:137–140
Costerton JW, Lewandowski Z, Caldwell D, Korber D, Lappin-Scott HM (1995) Microbial biofilms. Annu Rev Microbiol 49:711–745
Cuba TR, Blake NJ (1983) The initial development of a marine fouling assemblage on a natural substrate in a subtropical estuary. Bot Mar 26:259–264
Da Gama BA, Pereira RC, Carvalho AGV, Coutinho R, Yoneshigue-Valentin Y (2002) The effects of seaweed secondary metabolites on biofouling. Biofouling 18:13–20
Dagostino L, Goodman AE, Marshall KC (1991) Physiological responses induced in bacteria adhering to surfaces. Biofouling 4:113–119
Dalton HM, March PE (1998) Molecular genetics of bacterial attachment and biofouling. Curr Opin Biotechnol 9:252–255
Danese PN, Pratt LA, Kolter R (2000) Exopolysaccharide production is required for development of Escherichia coli K-12 biofilm architecture. J Bacteriol 182:3593–3596
Davies DG, Chakrabarty AM, Geesey GG (1993) Exopolysaccharide production in biofilms: substratum activation of alginate gene expression by Pseudomonas aeruginosa. Appl Environ Microbiol 59:1181–1186
Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP (1998) The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 280:295–298
Degen J, Uebele A, Retze A, Schmid-Staiger U, Trosch W (2001) A novel airlift photobioreactor with baffles for improved light utilization through the flashing light effect. J Biotechnol 92:89–94
De Mule MCZ, De Caire GZ, De Cano MS, De Halperin DR (1991) Bioactive compounds from Nostoc muscorum (cyanobacteria). Cytobios 66:169–172
de Nys R, Steinberg PD (1999) Role of secondary metabolites from algae and seagrasses in biofouling control. Recent advances in marine biotechnology. Vol III, biofilms, bioadhesion, corrosion, and biofouling. Oxford Press, Delhi, pp 223–244
de Nys R, Steinberg PD (2002) Linking marine biology and biotechnology. Curr Opin Biotechnol 13:244–248
de Nys R, Steinberg PD, Willemsen P, Dworjanyn SA, Gabaliesh CL, King RJ (1995) Broad spectrum effects of secondary metabolites from the red alga Delisea pulchra in antifouling assays. Biofouling 8:259–271
de Nys R, Leya T, Maximilien R, Asfar A, Nair PSR, Steinberg PD (1996) The need for standardised broad scale bioassay testing: a case study using the red algae Laurencia rigida. Biofouling 10:213–224
de Nys R, Dworjanyn SA, Steinberg PD (1998) A new method for determining surface concentrations of marine natural products on seaweeds. Mar Ecol Prog Ser 162:79–87
Devi P, Solimabi S, D’Souza L, Sonal S, Kamat SY, Singbal SYS (1997) Screening of some marine plants for activity against marine fouling bacteria. Bot Mar 40:87–91
Dexter SC (1996) Biofouling and biocorrosion. Corros Sci Eng 12:1–7
Dexter AF, Garson MJ, Hemling ME (1993) Isolation of a novel bastadin from the temperate marine sponge Ianthella sp. J Nat Prod 56:782–786
Dhawan BN, Garg HS, Goel AK, Srimal RC, Srivastava MN, Bhakuni S (1993) Bioactivity of marine organisms, part 7: screening of some marine fauna from the Indian coasts. Indian J Exp Biol 31:505–510
Dobretsov SV, Qian PY (2002) Effect of bacteria associated with the green alga Ulva reticulata on marine micro and macro-fouling. Biofouling 18:217–228
Dworjanyn SA (2001) Chemically mediated antifouling and the cost of producing secondary metabolites in a red alga. Dissertation, University of New South Wales, Sydney
Dworjanyn SA, de Nys R, Steinberg PD (1999) Localisation and surface quantification of secondary metabolites in the red alga Delisea pulchra. Mar Biol 133:727–736
Eberl L (1999) N-acyl homoserinelactone-mediated gene regulation in gram-negative bacteria. Syst Appl Microbiol 22:493–506
Eberl L, Winson MK, Sternberg C, Stewart GSAB, Christiansen G, Chhabra SR (1996) Involvement of N-acyl-l-homoserine lactone inducers in controlling the multicellular behaviour of Serratia liquefaciens. Mol Microbiol 20:127–136
Elvers KT, Lappin-Scott HM (2000) Encyclopedia of microbiology. Academic Press, San Diego
Engel S, Jensen PR, Fenical W (2002) Chemical ecology of marine microbial defense. J Chem Ecol 28:1971–1985
Eng-Wilmot DL, McCoy LF, Martin DF (1979) Isolation and synergis of a red tide (Gymnodinium breve) cytolic factor(s) from cultures of Gomphosphaeria aponina. In: Taylor DL, Seliger HH (eds) Toxic dinoflagellate blooms. Elsevier, Amsterdam, pp 355–360
Etahiri S, Bultel-Poncé V, Caux C, Guyot M (2001) New bromoditerpenes from the red alga Sphaerococcus coronopifolius. J Nat Prod 64:1024–1027
Evans SM, Birchenough AC, Brancato MS (2000) The TBT ban: out of the frying pan into the fire? Mar Pollut Bull 40:204–211
Falch B (1996) Was steckt in Cyanobakterien? Pharm Unserer Zeit 25:311–321
Fent K (1996) Ecotoxicology of organotin compounds. Crit Rev Toxicol 26:1–117
Fischer WS, Oliver LM, Walker WW, Manning CS, Lytle TF (1999) Decreased resistance of eastern oysters (Crassosterea virginica) to a protozoal pathogen (Perkinsus marinus) after sublethal exposure to tributyl tin oxide. Mar Environ Res 47:185–201
Fletcher RL (1975) Heteroantagonism observed in mixed algal cultures. Nature 253:534–535
Fletcher R (1989) A bioassay technique using the marine fouling green alga Enteromorpha. Int Biodeterior Biodegrad 25:407–422
Fowler MW, Cresswell RC, Stafford AM (1990) An economic and technical assessment of the use of plant cell cultures for natural product synthesis on an industrial scale. Ciba Found Symp 154:157–170
Franklin MA, Penn SG, Lebrilla CB, Lam TH, Pessah IN, Molinski TF (1996) Bastadin 20 and bastadin O-sulfate esters from Lanthella basta: novel modulators of the Ry1R FKBP12 receptor complex. J Nat Prod 59:1121–1127
Frey KM, Oppermann-Sanio FB, Schmidt H, Steinbuchel A (2002) Technical-scale production of cyanophycin with recombinant strains of Escherichia coli. Appl Environ Microbiol 68:3377–3384
Fuqua C, Winans SC, Greenberg EP (1997) Quorum sensing in bacteria: the LuxR–LuxI family of cell density-responsive transcriptional regulators. J Bacteriol 176:269–275
Fusetani N (2004) Biofouling and antifouling. Nat Prod Rep 21:94–104
Fusetani N, Hiroto H, Okino T, Tomono Y, Yoshumura E (1996) Antifouling activity of isocyanoterpenoids and related compounds isolated from a marine sponge and nudibranchs. J Nat Toxins 5:249–259
Gerwick WH (1990) Cytotoxic substances from the marine cyanophyte Hormithamnion enteromorphoides Grunow. US Patent number 4, 935, 529, Oregon State University, USA
Gerwick WH, Proteau PJ, Nagle DG (1994) Compound exhibiting antiproliferative acitivity against cells. US Patent number 5, 324, 739, Oregon State University, USA
Gerwick WH, Cone M, Zeller G (2000) Liposygenase metabolism in prokaryotes. Society of Industrial Microbiology Program and Abstracts, San Diego, CA, pp 100
Gitlitz MH (1981) Recent developments in marine antifouling coatings. J Coatings Technol 53:46–52
Givskov M, de Nys R, Manfield M, Gram L, Maximilien R, Eberl L, Moin S, Steinberg PD, Kjelleberg S (1996) Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J Bacteriol 178:6618–6622
Glombitza KW, Klapperich K (1985) Antibiotics from algae. XXXIV. Cleavage of the high-molecular-weight methylated phlorotannin fraction from the brown alga Pelvetia canaliculata. Bot Mar 28:139–144
Greer SP, Iken KB, McClintock JB, Amsler CD (2003) Individual and coupled effects of echinoderm extracts and surface hydrophobicity on spore settlement and germination in the brown alga Hincksia irregularis. Biofouling 19:315–326
Grinwis GCM, Boonstra A, van den Brandhof EJ, Dormans JAMA, Englesma M, Kuiper RV, van Loveren H, Wester PW, Vaal MA, Vethaak AD, Vos JG (1998) Short-term toxicity of bis (tri-n-butyl tin) oxide in flounder (Platichthys flesus): pathology and immune function. Aquat Toxicol 42:15–36
Gromov BV, Vepritskiy AA, Titova NN, Namkayeva KA, Alexandrova OV (1991) Production of the antibiotic cyanobacterin LU-1 by Nostoc linckia CALU 892 (cyanobacterium). J Appl Phycol 3:55–59
Gross EM, Wolk P, Juttner F (1991) Fischerellin, a new allelochemical from the freshwater cyanobacterium Fischerella muscicola. J Phycol 27:686–692
Hai T, Ahlers H, Gorenflo V, Steinbuchel A (2000) Axenic cultivation of anoxygenic phototrophic bacteria, cyanobacteria, and microalgae in a new closed tubular glass photobioreactor. Appl Microbiol Biotechnol 53:383–389
Hall L, Giddings J, Solomon K, Balcomb R (1999) An ecological risk assessment for the use of Irargol 1051 as an algicide for antifoulant paints. Crit Rev Toxicol 29:367–437
Hammer BK, Bassler BL (2003) Quorum sensing controls biofilm formation in Vibrio cholerae. Mol Microbiol 50:101–104
Harada H, Yamashita U, Kurihara H, Fukushi E, Kawabata J, Kamei Y (2002) Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res 22:2587–2590
Hashimoto S, Watanabe M, Noda Y, Hayashi T, Kurita Y, Takasu Y, Otsuki A (1998) Concentration and distribution of butyltin compounds in a heavy tanker route in the Strait of Malacca and in Tokyo Bay. Mar Environ Res 45:169–177
Hattori T, Shizuri Y (1996) A screening method for antifouling substances using spores of the fouling macroalga Ulva conglobata Kjellman. Fish Sci (Tokyo) 62:955–958
Hay ME (1996) Marine chemical ecology: what’s known and what’s next? J Exp Mar Biol Ecol 200:103–134
Hay ME, Steinberg PD (1992) The chemical ecology of plant herbivore interactions in marine versus terrestrial communities In: Rosenthal J, Berenbaum M (eds) Herbivores: their interactions with secondary plant metabolites, vol II. Evolutionary and ecological processes. Academic Press, New York, pp 317–413
Heilmann C, Schweitzer O, Gerke C, Vanittanakom N, Mack D, Gotz F (1996) Molecular basis of intercellular adhesion in the biofilm forming Staphylococcus epidermis. Mol Microbiol 20:1083–1091
Heilmann C, Hussain M, Peters G, Gotz F (1997) Evidence for autolysin-mediated primary attachment of Staphylococcus epidermis to a polystyrene surface. Mol Microbiol 24:1013–1024
Hellio C, Bourgougnon N, Le Gal Y (2000a) Phenoloxidase (E.C.1.14.18.1) from Mytilus edulis byssus gland: purification, partial characterization and application for screening products with potential antifouling activities. Biofouling 16:235–244
Hellio C, Bremer G, Pons A, Le Gal Y, Bourgougnon N (2000b) Inhibition of the development of microorganisms (bacteria and fungi) by extracts of marine algae from Brittany (France). Appl Microbiol Biotechnol 54:543–549
Hellio C, De La Broise D, Dufossé L, Le Gal Y, Bourgougnon N (2001) Inhibition of marine bacteria by extracts of macroalgae: potential use for environmentally friendly antifouling paints. Mar Environ Res 52:231–247
Hellio C, Pascal Berge J, Beaupoil C, Le Gal Y, Bougougnon N (2002) Screening of marine algal extracts for anti-settlement activities against microalgae and maroalgae. Biofouling 18:205–215
Henschell JR, Cook PA (1990) The development of a marine fouling community in relation to the primary film of microrganisms. Biofouling 2:1–11
Hentzer M, Riedel K, Rasmussen TB, Heydorn A, Andersen JB, Parsek MR, Rice SA, Eberl L, Molin S, Hoiby N, Kjelleberg S, Givskov M (2002) Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 148:87–102
Hirata K, Nakagami H, Takashina J, Mahmud T, Kobayashi M, In Y, Ishida T, Miyamoto K (1996) Novel violet pigment, nostocine A, an extracellular metabolite from the cyanobacterium Nostoc spongiaeforme. Heterocycles 43:1513–1519
Hoffmann D, Hevel JM, Moore RE, Moore BS (2003) Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. Gene 311:171–180
Holmström C, Kjelleberg S (1994) The effect of external biological factors on settlement of marine invertebrate larvae and new antifouling technology. Biofouling 8:147–160
Horiguchi T, Shiraishi H, Shimizu M, Yamazaki S, Morita M (1995) Imposex in Japanese gastropods (Neogastropoda and Mesogastropoda): Effects of tributyltin and triphenyltin from antifouling paints. Mar Poll Bull 31:402–405
Huang YM, Rorrer GL (2003) Cultivation of microplantlets derived from the marine red alga Agardhiella subulata in a stirred tank photobioreactor. Biotechnol Prog 19:418–427
Hunter JE, Anderson CD (2000) Antifouling paints and the environment. Technical paper. Antifouling discussions IMO/MEPC44, pp 6–13
Iken KB, Baker BJ (2003) Ainigmaptilones, sesquiterpenes from the Antarctic gorgonian coral Ainigmaptilon antarcticus. J Nat Prod 66:888–890
Isensee J, Watermann B, Berger H-D (1994) Emissions of antifouling-biocides into the North Sea—an estimation. Dtsch Hydrogr Z 46:355–365
Ishibashi M, Moore RE, Patterson GML, Xu C, Clardy J (1986) Scytophycins, cytotoxic and antimycotic agents from the cyanophyte Scytonema pseudohofmanni. J Org Chem 51:5300–5306
Jackson S (1991) Microalgae: their status as fouling organisms. Oebalia 17:295–303
Jaki B, Orjala J, Heilmann J, Linden A, Vogler B, Sticher O (2000) Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune. J Nat Prod 63:339–343
Janssen M, Tramper J, Mur LR, Wijffels RH (2002) Enclosed outdoor photobioreactors: light regime, photosynthetic efficiency, scale-up, and future prospects. Biotechnol Bioeng 81:193–210
Jennings JG, Steinberg PD (1997) Phlorotannins vs. others factors affecting epiphyte abundance on the kelp Ecklonia radiata. Ocealogia 109:461–473
John A, Griebe V, Nielsen PH (1999) Composition of Pseudomonas putida biofilms: accumulation of protein in the biofilm matrix. Biofouling 14:49–57
Kaebernick M, Dittmann E, Borner T, Neilan BA (2002) Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial nonribosomal peptide. Appl Environ Microbiol 68:449–455
Katsuoka M, Ogura C, Etoh H, Sakata K (1990) Galactosyl and sulfoquinovosyldiacylglycerols isolated from the brown algae, Undaria pinnatifida and Costaria costata as repellents of blue mussel, Mytilus edulis. Agric Biol Chem 54:3043–3044
Kjelleberg S, Steinberg P, eds (1994) Marine biofouling: problems and solution—executive summary. In: Biofouling: problems and solutions. Proceedings of the international workshop, UNSW, Sydney, Australia, pp 32–38
Kjelleberg S, Steinberg PD (2001a) Defenses against bacterial colonization of marine plants. In: Lindow S (eds) Phyllosphere microbiology. University of Berkeley Press, CA, pp 155–170
Kjelleberg S, Steinberg PD (2001b) Surface warfare in the sea. Microbiol Today 28:134–135
Kjelleberg S, Steinberg PD, Givskov M, Gram L, Manefield M, de Nys R (1997) Do marine natural products interfere with prokaryotic AHL regulatory systems? Aquat Microb Ecol 13:85–93
Klausen M, Aaes-Jorgensen A, Molin S, Tolker-Nielsen T (2003) Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms. Mol Microbiol 50:61–68
Kleerebezem M, Quadri, LE, Kuipers OP, de Vos WM (1997) Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol Microbiol 24:895–904
Kleinkauf H, von Döhren H (1997) Products of secondary metabolism. In: Rehm HJ, Reed G (eds) Biotechnology, vol 7. VCH, Weinheim, pp 308–309
König GM, Wright AD (1997) Laurencia rigida: chemical investigations of its antifouling dichloromethane extract. J Nat Prod 60:967–970
König GM, Wright AD, de Nys R (1999a) Halogenated monoterpenes from Plocamium costatum and their biological activity. J Nat Prod 62:383–385
König GM, Wright AD, Linden A (1999b) Plocamium hamatum and its monoterpenes: chemical and biological investigations of the tropical marine red alga. Phtyochemistry 52:1047–1053
Konstantinou IK, Albanis TA (2004) Worldwide occurrence and effects of antifouling paint booster biocides in the aquatic environment: a review. Environ Int 30:235–248
Kosourov S, Tsygankov A, Seibert M, Ghirardi ML (2002) Sustained hydrogen photoproduction by Chlamydomonas reinhardtii: Effects of culture parameters. Biotechnol Bioeng 78:731–740
Kubanek J, Jensen PR, Keifer PA, Sullards MC, Collins DO, William Fenical (2003) Seaweed resistance to microbial attack: a targeted chemical defense against marine fungi. Proc Natl Acad Sci USA 100:6916–6921
Kurata K, Taniguchi K, Shiraishi K, Minoru M (1990) Feeding-deterrent diterpenes from the brown alga Dilophus okamuri. Phytochemistry 29:3453–3455
Langlois G (1975) Effect of algal exudates on substratum selection by the motile marine telotroch Vorticello marina. J Protozool 221115–123
Lawrence JR, Korber DR, Hyle BD, Costerton JW, Caldwell DE (1991) Optical sectioning of microbial biofilms. J Bacteriol 173:6558–6567
Lustigmann B, Brown C (1991) Antibiotic production by marine algae isolated from the New York/New Jersey Coast. Bull Environ Contam Toxicol 46:329–335
Lustigmann B, Lee LH, Thees N, Masucci J (1992) Production of antibacterial substances by macroalgae of the New York/ New Jersey Coast. Bull Environ Contam Toxicol 49:743–749
Mack D, Fischer W, Krokotsch A, Leopold K, Hartmann R, Egge H, Laufs R (1996) The intercellular adhesion involved in biofilm accumulation of Staphylococcus epidermis is a linear β-1, 6-linked glucosaminoglycan: purification and structural analysis. J Bacteriol 178:175–183
Manefield M, de Nys R, Kumar N, Read R, Givskov M, Steinberg PD, Kjelleberg S (1999) Inhibition of LuxR-based AHL regulation by halogenated furanones from Delisea pulchra. Microbiology 145:283–291
Manefield M, Rasmussen TB, Henzter M, Andersen JB, Steinberg P, Kjelleberg S, Givskov M (2002) Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology 148:1119–1127
Martin D, Uriz M (1993) Chemical bioactivity of Mediterranean benthic organisms against embryos and larvae of marine invertebrates. J Exp Mar Biol Ecol 173:11–27
Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 21:796–802
Marwick JD, Wright PC, Burgess JG (1999) Bioprocess intensification for production of novel marine bacterial antibiotics through bioreactor operation and design. Mar Biotechnol 1:495–507
Mary A, Mary V, Rittschof D, Nagabhushanam R (1993) Bacterial–barnacle interaction: potential of using juncellins and antibiotics to alter structure of bacterial communities. J Chem Ecol 19:2155–2167
Maximilien R, de Nys R, Holmström C, Gram L, Givskov M, Crass K, Kjelleberg S, Steinberg PD (1998) Chemical mediation of bacterial surface colonisation by secondary metabolites from red alga Delisea pulchra Aquat Microb Ecol 15:233–246
Mayer AM, Gustafson KR (2003) Marine pharmacology in 2000: antitumor and cytotoxic compounds. Int J Cancer 105:291–299
McLachlan J, Craigie JS (1964) Algal inhibition by yellow ultra-violet absorbing substances from Fucus vesiculosus. Can J Bot 42:287–292
McLachlan J, Craigie JS (1966) Antialgal activity of some simple phenols. J Phycol 2:133–135
Mendola D (2003) Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics. Biomol Eng 20(4–6):441–458
Miao S, Anderson RJ, Allen TM (1990) Cytotoxic metabolites from the sponge Lanthella basta collected in Papua New Guinea. J Nat Prod 53:1441–1446
Miguel O (2000) Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors. J Appl Phycol 12:499–506
Miki W, Kon-ya K, Mizobuchi S (1996) Biofouling and marine biotechnology: new antifoulants from marine invertebrates. J Mar Biotechnol 4:117–120
Mizukoshi S, Matsuoka H, Katou H, Noda H (1992) Search of bioactive substances from marine algae. Bull Fac Bioresour Mie Univ Seibutsushigen Kiyo 8:27–34
Moffitt MC, Neilan BA (2001) On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genus Nodularia. FEMS Microbiol Lett 196:207–214
Molina E, Fernandez J, Acien FG, Chisti Y (2001) Tubular photobioreactor design for algal cultures. J Biotechnol 92:113–131
Moore RE (1982) Toxins, anticancer agents and tumor promoters from marine prokaryotes. Pure Appl Chem 54:1919–1934
Moore RE (1996) Cyclic peptides and depsipeptides from cyanobacteria: a review. J Ind Microbiol 16:134–143
Moore RE, Patterson GML, Carmichael WW (1988) New pharmaceuticals from cultured blue-green algae. In: Fauntin DG (eds) Biomedical importance of marine organisms—memoirs of the Californian Academy of Science, vol 13. Californian Academy of Science, San Franscisco, pp 143–150
Morita M, Watanabe Y, Okawa T, Saiki H (2001) Photosynthetic productivity of conical helical tubular photobioreactors incorporating Chlorella sp. under various culture medium flow conditions. Biotechnol Bioeng 74:136–144
Morita M, Watanabe Y, Saiki H (2002) Photosynthetic productivity of conical helical tubular photobioreactor incorporating Chlorella sorokiniana under field conditions. Biotechnol Bioeng 77:155–162
Muller-Feuga A, Pruvost J, Le Guedes R, Le Dean L, Legentilhomme P, Legrand J (2003) Swirling flow implementation in a photobioreactor for batch continuous cultures of Porphyridium cruentum. Biotechnol Bioeng 84:544–551
Murakami N, Orimoto T, Lamura H, Ueda T, Nagai SI, Sakakibara J, Yamada N (1991) Studies on glycolipids. 3. Glyceroglycolipids from an axenically cultured cyanobacterium Phormidium tenue. Chem Pharm Bull Tokyo 39:2277–2281
Nagai H, Satake M, Yasumoto T (1990) Antimicrobial activities of polyether compounds of dinoflagellate origins. J Appl Phycol 2:305–308
Nagai H, Mikami Y, Yazawa K, Gonoi T, Yasumoto T (1993) Biological activities of novel polyether antifungals, gambieric acids A and B from a marine dinoflagellate Gambierdiscus toxicus. J Antibiot 46:520–522
Nagle DG, Paul VJ (1999) Production of secondary metabolites by filamentous tropical marine cyanobacteria: ecological functions of the compounds. J Phycol 35:1412–1421
Nagle DG, Paul VJ, Roberts MA (1996) Ypaoamide, a new broadly acting feeding deterrent from the marine cyanobacterium Lyngbya majuscula. Tetrahedron Lett 37:6263–6266
Namikoshi M, Rinehart KL (1996) Bioactive compounds produced by cynanobacteria. J Ind Microbiol 17:373–384
Nandi R, Sengupta S (1998) Microbial production of hydrogen: an overview. Crit Rev Microbiol 24:61–84
Ohta S, Chang T, Ikegami N, Kondo M, Miyata H (1993) Antibiotic substances produced by a newly isolated marine microalga, Chlorococcum HS-101. Bull Environ Contam Toxicol 50:171–178
Ohta S, Chang T, Kawashima A, Nagate T, Murase M, Nakanisi H, Miyata H, Kondo M (1994) Bull Environ Contam Toxicol 52:673–680
Omae I (2003) General aspects of tin-free antifouling paints. Chem Rev 103:3431–3448
Oosthuizen MC, Steyn B, Theron J, Cosette P, Lindsay D, Von Holy A, Brozel VS (2002) Proteomic analysis revelas differential protein expression by Bacillus cereus during biofilm formation. Appl Environ Microbiol 68:2770–2780
O’Toole GA, Kaplan H, Kolter R (2000) Biofilm formation as microbial development. Annu Rev Microbiol 54:49–79
Otto K, Norbeck J, Larsson T, Karlsson KA, Hermansson M (2001) Adhesion of type 1-fimbriated Escherichia coli to abiotic surfaces leads to altered composition of outer membrane proteins. J Bacteriol 183:2445–2453
Padmakumar K, Ramaswamy S, Ayyakkannu K, Nair PGV (1993) Analgesic activity of marine plants. In: Devadsan K, Mukundan MK, Antony PD, Nair PGV, Perigreen PA, Joseph J (eds) Nutrients and bioactive substances in aquatic organisms. Society of Fisheries Technologists (India), Cochin, pp 25–30
Patterson GML, Carmelli S (1992) Biological effects of tolytoxin (6-hydroxy-7-O-methylscytophyin b), a potent bioactive metabolite from cyanobacteria. Arch Microbiol 157:406–410
Paul VJ (1992) Ecological roles of marine natural products. Cornell University Press, New York
Paul VJ, Puglisi MP (2004) Chemical mediation of interactions among marine organisms. Nat Prod Rep 21:189–209
Paul VJ, Van Alstyne KL (1988) Chemical defense and chemical variation in some tropical pacific species of Halimeda (Halimedaceae; Chlorophyta). Coral Reefs 6:263–269
Paul VJ, Littler M, Littler DS, Fenical W (1987) Evidence for chemical defense in tropical green alga Caulerpa ashmeadii (Caulerpaceae: Chlorophyta). Isolation of new bioactive sesquiterpenoids. J Chem Ecol 13:1171–1185
Pereira RC, Carvalho AG, Gama BA, Coutinho R (2002) Field experimental evaluation of secondary metabolites from marine invertebrates as antifoulants. Braz J Biol 62:311–320
Peters L, König GM, Wright AD, Pukall R, Stackebrandt R, Eberl L, Riedel K (2003) Secondary metabolites of Flustra foliacea and their influence on bacteria. Appl Envir Microbiol 69:3469–3475
Pettit GR, Butler MS, Bass CG, Doubek DL, Williams MD, Schimdt JM, Pettit RK, Hooper JNA, Tackett LP, Filiatrault MJ (1995) Antineoplastic agents, 326. The stereochemistry of bastadins 8, 10, and 12 from the Bismarck archipelago marine sponge Lanthella basta. J Nat Prod 58:680–688
Pietra F (1990) A secret world: natural products of marine life; 1st edn. Birkhäuser, Basel
Polzin JJ, Rorrer GL, Cheney DP (2003) Metabolic flux analysis of halogenated monoterpene biosynthesis in microplantlets of the macrophytic red alga Ochtodes secundiramea. Biomol Eng 20:205–15
Ponasik JA, Conova S, Kinghorn D, Kinney WA, Rittschof D, Ganem B (1998) Pseudoceratidine, a marine natural product with antifouling activity: synthetic and biological studies Tetrahedron 54:6977–6986
Price RR, Patchan M, Clare AS, Rittschof D, Bonaventura J (1994) Performance enhancement of natural antifouling compounds and their analogs through microencapsulation and controlled release. In: Thompson MF, Nagabhushanam R, Sarojini R, Fingerman M (eds) Recent developments in biofouling control. Balkema, Rotterdam, pp 321–334
Prigent-Combaret C, Vidal O, Dorel C, Lejeune P (1999) Abiotic surface sensing and biofilm-dependent regulation of gene expression in Escherichia coli. J Bacteriol 181:5993–6002
Pulz O, Scheibenbogen K (1998) Photobioreactors: design and performance with respect to light energy input. In: Scheper T (ed) Advances in biochemical engineering/biotechnology. Wiley-VCH, Weinheim, pp 107–136
Purevdorj B, Stoodley P (2003) The role of cell signaling in biofilm development. In: Lens P, O’Flaherty V, Moran A, Stoodley P, Mahony T (eds.) Biofilms in industry, medicine and environmental biotechnology—characteristics, analysis and control. IWA Publishing, London, pp 63–78
Ragan MA, Glombitza KW (1986) Phlorotannins, brown algal polyphenols. Prog Phycol Res 4:129–141
Rasmussen K, Østgaard K (2003) Adhesion of the marine bacterium Pseudomonas sp. NCIMB 2021 to different hydrogel surfaces. Water Res 37:519–534
Rasmussen TB, Manefield M, Andersen JB, Eberl L, Anthoni U, Christophersen C, Steinberg P, Kjelleberg S, Givskov M (2000) How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 12:3237–3244
Reid RC, Abbenante G, Taylor SM, Fairlie DP (2003) A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. J Org Chem 68:4464–4471
Ren D, Sims JJ, Wood TK (2001) Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone. Environ Microbiol 3:731–736
Ren D, Sims JJ, Wood TK (2002) Inhibition of biofilm formation and swarming of Bacillus subtilis by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone. Lett Appl Microbiol 34:293–299
Riguera R (1997) Isolating bioactive compounds from marine organisms. J Mar Biotechnol 5:187–193
Rittschof D (1999) Fouling and natural products as antifoulants. In: Fingerman M, Nagabhushanam R, Thompson MF (eds) Recent advances in marine biotechnology. Science Publishers, USA, pp 245–257
Rittschof D (2001) Natural products antifoulants and coatings development. In: McClintock JB, Baker BJ (eds) Marine chemical ecology. Marine science series. CRC, London, pp 543–566
Rohde H, Knobloch JK, Horstkotte MA, Mack D (2001) Correlation of biofilm expression types of Staphylococcus epidermidis with polysaccharide intercellular adhesin synthesis: evidence for involvement of icaADBC genotype-independent factors. Med Microbiol Immunol 190:105–112
Romanos MT, Andrada-Serpa MJ, Mourao PA, Yoneshigue-Valentin Y, Costa SS, Pereira MS, Miranda MM, Goncalves JL, Wigg MD (2002) A sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells. Antivir Chem Chemother 13:219–221
Rosell KG, Srivastava LM (1987) Fatty acids as antimicrobial substances in brown algae. In: Ragan A, Bird CJ (eds) Twelfth international seaweed symposium. Developments in hydrobiology 41 (reprinted from Hydrobiologia 151/152). Junk, Dordrecht, pp 471–475
Ruiz JM, Bryan GW, Gibbs PE (1995) Acute and chronic toxicity of tributytin (TBT) to pediveliger larvae of the bivalve Scrobicularia plana. Mar Biol 124:119–126
Sánchez Mirón A, Contreras Gómez A, García Camacho F, Molina Grima E, Chisti Y (1999) Comparative evaluation of compact photobioreactors for large-scale monoculture of microalgae. J Biotechnol 70:249–270
Sastry VMVS, Rao GRK (1994) Antibacterial substances from marine algae: successive extraction using benzene, chloroform and methanol. Bot Mar 37:357–360
Sato A (1996) The search for new drugs from marine organisms. J Toxicol Toxin Rev 15:171–198
Sauer K (2003) The genomics and proteomics of biofilm formation. Genome Biol 4:219
Sauer K, Camper AK, Ehrlich GD, Costerton JW, Davies DG (2002) Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol 184:1140–1154
Schembri MA, Kjaergaad K, Klemm P (2003) Global gene expression in Escherichia coli biofilms. Mol Microbiol 48:253–627
Schmitt TM, Hay ME, Lindquist N (1995) Constraints on chemically mediated coevolution: multiple functions for seaweed secondary metabolites. Ecology 76:107–123
Shimizu Y (2000) Microalgae as a drug source. In: Fusetani N (ed) Drugs from the sea. Karger, Basel, pp 30–45
Shimizu Y (2003) Microalgal metabolites. Curr Opin Microbiol 6:236–243
Shin HW, Smith CM (2001) Antifouling activities of six non-toxic chemicals on spore attachment of Ulva fasciata. J Environ Biol 22:145–151
Siddhanta AK, Ramavat BK, Chauhan VD, Achari B, Dutta PK, Pakrashi SC (1991) Sulphonoglycolipid from the green alga Enteromorpha flexuosa (wulf.) J Agric Bot Mar 34:365–367
Siddhanta AK, Mody KH, Ramavat BK, Chauhan VD, Garg HS, Goel AK, Doss MJ, Srivastava GK, Patnaik GK, Kamboj VP (1997) Bioactivity of marine organisms, part 8: screening of some marine flora of western coast of India. Indian J Exp Biol 35:638–643
Sieburth JM, Conover JT (1965) Sargassum tannin, an anti-biotic which retards fouling. Nature 208:52–53
Smyrniotopoulos V, Abatis D, Tziveleka LA, Tsitsimpikou C, Roussis V, Loukis A, Constantinos V (2003) Acetylene sesquiterpenoid esters from the green alga Caulerpa prolifera. J Nat Prod 66:21–24
Sridhar KR, Vidyavathi N (1991) Antimicrobial activity of seaweeds. Acta Hydrochim Hydrobiol 19:455–496
Steinberg PD, de Nys R (2002) Chemical mediation of colonization of seaweed surfaces. J Phycol 38:621–629
Steinberg PD, de Nys R, Kjelleberg S (1998) Chemical inhibition of epibiota by Australian seaweeds. Biofouling 12:227–24
Steinberg PD, de Nys R, Kjelleberg S (2001) Chemical mediation of surface colonisation. In: McClintock J, Baker B (eds) Marine chemical ecology. Marine science series. CRC Press, Boca Raton
Stupak ME, Garcia MT, Pérez MC (2003) Non toxic alternative compounds for marine antifouling paints. Int Biodeterior Biodegrad 52:49–52
Suzuki T, Matsuda R, Saito Y (1992) Molecular species of tri-n-butyltin compounds in marine products. J Agric Food Chem 40:1437–1443
Szewzyk U, Holmstroem C, Wrangstadh M, Samuelsson MO, Maki JS, Kjelleberg S (1991) Relevance of the exopolysaccharide of marine Pseudomonas sp. strain S9 for the attachment of Ciona intestinalis larvae. Mar Ecol Prog Ser 75:259–265
Takahashi Y, Daitoh M, Suzuki M, Abe T, Masuda M (2002) Halogenated metabolites from the new Okinawan red alga Laurencia yonaguniensis. J Nat Prod 65:395–398
Takamatsu S, Hodges TW, Rajbhandari I, Gerwick WH, Hamann MT, Nagle DG (2003) Marine natural products as novel antioxidant prototypes. J Nat Prod 66:605–608
Takasawa R, Ogura C, Watanabe H, Etoh K, Sakata K, Ina K (1992) An efficient laboratory matching and screening method for antifouling substances using blue mussel Mytilus edulis and antimicrobial assay. Biosci Biotechnol Biochem 56:1208–1211
Tanaka N, Asakawa A (1988) Allelophatic effect of mucilage released from a brown alga Sargassum horneri on marine diatoms. Nippon Suisan Gakkaishi 54:1711–1714
Teuscher E, Lindequist U (1994) Biogene Gifte. Biologie-Chemie-Pharmakologie. Fischer, Stuttgart
Teuscher E, Lindequist U, Mundt S (1992) Cyanobakterien, Quellen biogener Wirkstoffe. Pharm Ztg Wiss 137:57–69
Tietze LF, Bell HP, Chandrasekhar S (2003) Natural product hybrids as new leads for drug discovery. Angew Chem Int Ed Engl 42:3996–4028
Tillett D, Dittmann E, Erhard M, von Dohren H, Borner T, Neilan BA (2000) Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system. Chem Biol 10:753–764
Tredici MR, Zittelli GC (1998) Efficiency of sunlight utilization: tubular versus flat photobioreactors. Biotechnol Bioeng 57:187–197
Tsoukatou M, Hellio C, Vagias C, Harvala C, Roussis V (2002) Chemical defense and antifouling activity of three Mediterranean sponges of the genus Ircinia. Z Naturforsch 57:161–171
Tsygankov AA, Borodin VB, Rao KK, Hall DO (1999) H(2) photoproduction by batch culture of Anabaena variabilis ATCC 29413 and its mutant PK84 in a photobioreactor. Biotechnol Bioeng 64:709–715
Tsygankov AA, Fedorov AS, Kosourov SN, Rao KK (2002) Hydrogen production by cyanobacteria in an automated outdoor photobioreactor under aerobic conditions. Biotechnol Bioeng 80:777–783
Tziveleka LA, Vagias C, Roussis V (2003) Natural products with anti-HIV activity from marine organisms. Curr Top Med Chem 3:1512–1535
Umemura K, Yanase K, Suzuki M, Okutani K, Yamori T, Andoh T (2003) Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide. Biochem Pharmacol 66:481–487
Vairappan CS (2003) Potent antibacterial activity of halogenated metabolites from Malaysian red algae, Laurencia majuscula (Rhodomelaceae, Ceramiales). Biomol Eng 20:255–259
Vairappan CS, Suzuki M, Abe T, Masua M (2001) Halogenated metabolites with antibacterial activity from the Okinawan Laurencia species. Phytochemistry 58:517–523
Vanelle L, Le Gal Y (1995) Marine antifoulants from North Atlantic algae and invertebrates. J Mar Biotechnol 3:161–163
Wahidulia S, D’souza L, Das B, Patnaik GK (1987) Oxtoxic principle of red alga Amphiroa fragilissima. Bot Mar 30:411–412
Wahl M (1989) Marine epibiosis. I. Fouling and antifouling: some basic aspects. Mar Ecol Prog Ser 58:175–189
Walters LJ, Hadfield MG, Smith CM (1996) Water borne chemical compounds in tropical macro-algae: positive and negative cues for larval settlement. Mar Biol 126:383–393
Willemsen PR, Ferrari GM (1993) The use of antifouling compounds from sponges in antifouling paints. Surf Coat Int 10:423–427
Wilsanand V, Wagh AB, Bapuji M (2001) Antifouling activities of octocorals on some marine macrofoulers. Microbes 104:131–140
Wu JT, Kuo-Huang LL, Lee J (1998) Algicidal effect of Peridinium bipes on Microcystis aeruginosa. Curr Microbiol 37:257–261
Xu N, Fan X, Yan X, Li X, Niu R, Tseng CK (2003) Antibacterial bromophenols from the marine red alga Rhodomela confervoides. Phytochemistry 62:1221–1224
Yang RY, Bayraktar O, Pu HT (2003) Plant-cell bioreactors with simultaneous electropermeabilization and electrophoresis. J Biotechnol 100:13–22
Yang X, Shimizu Y, Steiner JR, Clardy J (1993) Nostoclide I and II, extracellular metabolites from a symbiotic cyanobacterium, Nostoc sp., from the lichen Peltigera canina. Tetrahedron Lett 34:761–764
Yim JH, Kim SJ, Ahn SH, Lee HK (2003) Optimal conditions for the production of sulphated polysaccharide by marine microalga Gyrodinium impundicum strain KG03. Biomol Eng 20:273–280
Yim JH, Kim SJ, Ahn SH, Lee CK, Rhie KT, Lee HK (2004) Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03. Mar Biotechnol 6:17–25
Youngblood JP, Andruzzi L, Ober CK, Hexemer A. Kramer EJ, Callow JA, Finlay JA, Callow ME (2003) Coatings based on side-chain ether-linked poly(ethylene glycol) and fluorocarbon polymers for the control of marine biofouling. Biofouling 19:91–98
Zahuranec BJ (1991) The United States Navy and research on bioactive substances from the sea. In: Thompson MF, Sarojini R, Nagabhushanam R (eds) Bioactive compounds from marine organisms with emphasis on the Indian Ocean, an Indo-United States Symposium. Balkema, Rotterdam, pp 4–6
Acknowledgements
Punyasloke Bhadury acknowledges the Department for International Development (DFID), Heriot Watt University and the Association of Commonwealth Universities for the provision of a DFID Scholarship. Phillip Wright acknowledges the Engineering and Physical Sciences Research Council for an Advanced Research Fellowship (GR/A11311/01). We thank Professor Thomas K. Wood of The University of Connecticut for helpful advice on furanones.
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Bhadury, P., Wright, P.C. Exploitation of marine algae: biogenic compounds for potential antifouling applications. Planta 219, 561–578 (2004). https://doi.org/10.1007/s00425-004-1307-5
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DOI: https://doi.org/10.1007/s00425-004-1307-5