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Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy

  • Neurophthalmology
  • Published:
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Abstract

Purpose

The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA).

Methods

In this retrospective, observational case-control study four NA-AION patients and one A-AION patient were examined by FA, ICGA and OCT-A within 2 weeks from disease presentation. The characteristics of the images were analyzed. Optic nerve head (ONH) and radial peripapillary capillaries (RPC) vessel densities (VDs) were compared between NA-AION and controls.

Results

In two of four NA-AION cases and in the A-AION patient, OCT-A clearly identified the boundary of the ischemic area at the level of the optic nerve head, which was comparable to optic disc filling defects detected by FA. In the other two NA-AION cases, a generalized leakage from the disc was visible with FA, yet OCT-A still demonstrated sectorial peripapillary capillary network reduction. Both ONH and RPC VDs were reduced in NA-AION patients, when compared to controls.

Conclusions

OCT-A was able to identify microvascular defects and VD reduction in cases of acute optic disc edema due to NA-AION and A-AION. OCT-A provides additional information in ischemic conditions of the optic nerve head.

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Funding

No funding was received for this research.

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Authors and Affiliations

  1. Studio Oculistico d’Azeglio, Piazza Galileo 6, 40123, Bologna, Italy

    Nicole Balducci & Piero Barboni

  2. Ophthalmology Unit, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    Nicole Balducci, Mariachiara Morara, Chiara Veronese, Nicoletta Lelli Casadei & Antonio Ciardella

  3. Scientific Institute San Raffaele, Via Olgettina, 60, Milan, Italy

    Piero Barboni

  4. GB Bietti Foundation IRCCS, Via Livenza, 3, 00128, Rome, Italy

    Giacomo Savini & Vincenzo Parisi

  5. Department of Ophthalmology, Doheny Eye Institute, University of California, Los Angeles, CA, USA

    Alfredo A. Sadun

Authors
  1. Nicole Balducci
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  2. Mariachiara Morara
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  3. Chiara Veronese
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  4. Piero Barboni
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  5. Nicoletta Lelli Casadei
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  6. Giacomo Savini
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  7. Vincenzo Parisi
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  8. Alfredo A. Sadun
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  9. Antonio Ciardella
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Corresponding author

Correspondence to Nicole Balducci.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financtial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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None of the author has proprietary interest in the content of the manuscript.

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Balducci, N., Morara, M., Veronese, C. et al. Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 255, 2255–2261 (2017). https://doi.org/10.1007/s00417-017-3774-y

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  • DOI: https://doi.org/10.1007/s00417-017-3774-y

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