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The effect of intravitreal triamcinolone on diabetic macular oedema

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Abstract

Background

Diabetic macular oedema is a frequent cause of visual loss in patients with diabetic retinopathy. The purpose of this study was to assess the efficacy of intravitreal triamcinolone acetonide in reducing diabetic macular oedema and improving visual acuity.

Methods

In this prospective study 12 eyes of 12 patients with diabetic macular oedema unresponsive to prior laser treatment received an intravitreal injection of 4 mg triamcinolone acetonide. Examinations were performed 1 day preoperatively and at 1 week and 1, 3, 6, and 9 months after surgery and included slit-lamp examination, measurement of IOP, assessment of distance as well as reading visual acuity and assessment of macular thickness using optical coherence tomography (OCT).

Results

Mean age of the patients (mean±SD) was 66.6±8.6 years. Mean best-corrected visual acuity (BCVA) for distance (LogMAR using ETDRS charts) improved from 1.0±0.4 preoperatively to 0.9±0.4 (p=0.01) 1 week and to 0.9±0.4 (p=0.02) 1 month postoperatively. Mean BCVA for reading vision (LogRAD using Radner Reading Charts) improved from 1.1±0.4 preoperatively to 0.9±0.4 (p=0.002) 1 month postoperatively. Mean macular thickness decreased from 450±190 (μm) preoperatively to 305±153 (p=0.02) 1 month postoperatively. No significant improvement in VA and no significant reduction of macular thickness could be observed 3, 6, and 9 months postoperatively. Mean intraocular pressure significantly increased from 14.7±2.7 mmHg preoperatively to 16.9±3.0 mmHg at 1 month (p=0.02).

Conclusion

A single intravitreal injection of triamcinolone acetonide led to a significant improvement in mean VA in patients with diabetic macular oedema. However, the significant effect was not permanent and persisted for only 1 month.

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References

  1. Antcliff RJ, Spalton DJ, Stanford MR, Graham EM, Ffytche TJ, Marshall J (2001) Intravitreal triamcinolone for uveitic cystic macular edema: an optical coherence tomography study. Ophthalmology 108:765–772

    Article  CAS  PubMed  Google Scholar 

  2. Early Treatment Diabetic Retinopathy Study Research Group (1985) Photocoagulation for diabetic macular edema: early treatment diabetic retinopathy study. Report number 1. Arch Ophthalmol 103:1796–1806

    Google Scholar 

  3. Fong DS, Ferris FL III, Davis MD, Chew EY (1999) Causes of severe visual loss in the early treatment diabetic retinopathy study: ETDRS report no. 24. Early Treatment Diabetic Retinopathy Study Research Group. Am J Ophthalmol 127:137–141

    Article  CAS  PubMed  Google Scholar 

  4. Jonas JB, Kreissig I, Söfker A, Degenring RF (2003) Intravitreal injection of triamcinolone for diffuse diabetic macular edema. Arch Ophthalmol 121:57–61

    CAS  PubMed  Google Scholar 

  5. Jonas JB, Akkoyun I, Kamppeter, Kreissig I, Degenring RF (2004) Branch retinal vein occlusion treated by intravitreal triamcinolone acetonide. Eye:1–7 (advance online publication Apr 23)

  6. Klein R, Klein BE, Moss SE, Cruickshanks KJ (1998) The Wisconsin epidemiologic study of diabetic retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmology 105:1801–1815

    Article  CAS  PubMed  Google Scholar 

  7. Lee CM, Olk RJ (1991) Modified grid laser photocoagulation for diffuse diabetic macular edema. Ophthalmology 98:1594–1602

    CAS  PubMed  Google Scholar 

  8. Martidis A, Duker JS, Greenberg PB, Rogers AH, Puliafito CA, Reichel E, Baumal C (2002) Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology 109:920–927

    Article  PubMed  Google Scholar 

  9. Massin P, Audren F, Haouchine B, Erginay A, Bergmann JF, Benosman R, Caulin C, Gaudric A (2004) Intravitreal triamcinolone acetonide for diabetic diffuse macular edema. Ophthalmology 111:218–225

    Article  PubMed  Google Scholar 

  10. Park CH, Jaffe GJ, Fekrat S (2003) Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol 136:419–425

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Dr. Richter-Müksch, M.D., Department of Ophthalmology, Medical University of Vienna, for providing technical assistance.

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Authors and Affiliations

  1. Department of Ophthalmology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Katharina Krepler, Julia Wagner, Stefan Sacu & Andreas Wedrich

Authors
  1. Katharina Krepler
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  2. Julia Wagner
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  3. Stefan Sacu
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  4. Andreas Wedrich
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Corresponding author

Correspondence to Katharina Krepler.

Additional information

The study was carried out at the Medical University of Vienna, Department of Ophthalmology, Austria. The authors have no proprietary or financial interest in any product mentioned in this article and received no financial support for this study.

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Krepler, K., Wagner, J., Sacu, S. et al. The effect of intravitreal triamcinolone on diabetic macular oedema. Graefe's Arch Clin Exp Ophthalmol 243, 478–481 (2005). https://doi.org/10.1007/s00417-004-1059-8

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  • DOI: https://doi.org/10.1007/s00417-004-1059-8

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