Abstract.
Lack of normal structural asymmetry of the anterior cingulate gyrus (ACG) in patients with schizophrenia has been reported in our previous study. However, to our knowledge, no morphological studies of the brain have examined changes in ACG volume in patients with schizotypal features. We investigated the volume of the gray matter and the white matter of the ACG by three-dimensional magnetic resonance imaging (MRI) in 24 patients who met the ICD-10 criteria for schizotypal disorder (12 males, 12 females) in comparison with 48 age- and gender-matched healthy control subjects (24 males, 24 females) and 40 patients with schizophrenia (20 males, 20 females). As we reported previously, right ACG gray matter volume was significantly reduced in the female patients with schizophrenia compared with the female controls. On the other hand, the gray and white matter volume of the ACG in the patients with schizotypal disorder did not differ significantly from the values in the healthy controls or the patients with schizophrenia. However, the female patients with schizotypal disorder showed a lack of right-greater-than-left asymmetry of the ACG gray and white matter found in the female controls. These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 28 May 2002 / Accepted: 30 October 2002
Correspondence to T. Takahashi
Rights and permissions
About this article
Cite this article
Takahashi, T., Suzuki, M., Kawasaki, Y. et al. Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder. European Archives of Psychiatry and Clinical Neurosciences 252, 268–277 (2002). https://doi.org/10.1007/s00406-002-0392-3
Issue Date:
DOI: https://doi.org/10.1007/s00406-002-0392-3