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Expression of magnesium transporter genes in head and neck cancer patients underwent neoadjuvant cisplatin-based chemotherapy

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Abstract

We aimed to investigate expression of magnesium transporter genes in patients with head and neck cancer who underwent cisplatin-based neoadjuvant chemotherapy and their association with serum magnesium level. Head and neck cancer patients scheduled to undergo neoadjuvant cisplatin-based chemotherapy were eligible for enrollment. Blood samples were obtained at three time points: prior to, during, and after completion of chemotherapy. Expression levels of magnesium transporter genes were determined by quantitative real-time PCR. A total of 23 patients were included in the final analysis. The average serum magnesium levels dropped 6.98 and 5.20 % during and after completion of chemotherapy. There were neither significant associations between serum magnesium level and demographic variables nor tumor-related variables. SLC41A1 expression level was positively correlated with serum magnesium whereas TRPM6 expression level was negatively correlated with serum magnesium. Serum magnesium level decreased during cisplatin-based chemotherapy in head and neck cancer patients. Further studies are warranted to investigate optimal magnesium measurement and substitution protocol.

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Acknowledgments

The authors thank the Biostatistics Task Force of Taichung Veterans General Hospital for their assistance with the statistical analysis. The study was supported by grants from Taichung Veterans General Hospital (TCVGH-1007002C), Taichung, Taiwan, Republic of China. There was no potential conflict of interest in this research. Taichung Veterans General Hospital had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.

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Authors and Affiliations

  1. Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan

    Yu-Jung Lin, Rong-San Jiang & Shih-An Liu

  2. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan

    Fu-Chou Cheng & Li-Sheng Chien

  3. Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan

    Jin-Ching Lin

  4. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

    Jin-Ching Lin & Shih-An Liu

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  1. Yu-Jung Lin
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  2. Fu-Chou Cheng
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  3. Li-Sheng Chien
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  4. Jin-Ching Lin
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  5. Rong-San Jiang
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Correspondence to Shih-An Liu.

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Lin, YJ., Cheng, FC., Chien, LS. et al. Expression of magnesium transporter genes in head and neck cancer patients underwent neoadjuvant cisplatin-based chemotherapy. Eur Arch Otorhinolaryngol 272, 3051–3057 (2015). https://doi.org/10.1007/s00405-015-3563-3

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  • DOI: https://doi.org/10.1007/s00405-015-3563-3

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