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Clinical subgroups and antifungal susceptibilities in fungal culture-positive patients with chronic rhinosinusitis

  • Rhinology
  • Published:
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Abstract

The goal of this study was to investigate clinical characteristics of chronic rhinosinusitis (CRS) in patients with positive fungal cultures. Fungal cultures were taken from 55 CRS patients and 20 healthy volunteers. Susceptibilities of isolated fungi to fluconazole, amphotericin B, itraconazole, voriconazole, and caspofungin were determined in CRS patients. Fungi grew in the cultures from 44 (80%) CRS patients and 17 (85%) healthy volunteers. Of the patients with positive fungal cultures, 5 (11.3%) had fungal hypersensitivity (FH), and 21 (47.7%) had eosinophilic mucin (EM). Fungal culture-positive patients with EM were more likely to be associated with presence of polyps and higher CT scores than those without EM (P < 0.05). All the patients with FH had EM and polyps, and CT scores of those patients were highest. The sensitivity rates of fungal isolates were 97.8% for amphotericin B, caspofungin, and voriconazole; 74.4% for itraconazole; and 6.4% for fluconazole. The presence of EM with or without FH leaded to more extended CRS, but a part of positive fungal cultures were together with EM in patients with CRS. Sensitivity to antifungal agents, except fluconazole, was high. Because many factors can contribute to the pathogenesis of CRS, medical treatment should be considered on a case-by-case basis.

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Acknowledgments

This study was supported financially by Baskent University Research Foundation (Project No. KA05/06), and was presented at the 3. National Rhinology Congress April 21–25, 2007, Turkey.

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Authors and Affiliations

  1. Department of Otolaryngology, Baskent University Faculty of Medicine, Ankara, Turkey

    Selim S. Erbek, Seyra Erbek, Erkan Tarhan & Ozcan Cakmak

  2. Department of Infectious Diseases and Clinical Microbiology, Baskent University Faculty of Medicine, Ankara, Turkey

    Kivanc Serefhanoglu, Muge Demirbilek, Fusun Can & Hale Turan

  3. Department of Otolaryngology, Baskent University Konya Teaching and Research Center, Saray Caddesi No: 1, Selcuklu Konya, Turkey

    Selim S. Erbek

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  1. Selim S. Erbek
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  2. Kivanc Serefhanoglu
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  3. Seyra Erbek
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  4. Muge Demirbilek
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  5. Fusun Can
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Correspondence to Selim S. Erbek.

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Erbek, S.S., Serefhanoglu, K., Erbek, S. et al. Clinical subgroups and antifungal susceptibilities in fungal culture-positive patients with chronic rhinosinusitis. Eur Arch Otorhinolaryngol 265, 775–780 (2008). https://doi.org/10.1007/s00405-007-0542-3

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  • DOI: https://doi.org/10.1007/s00405-007-0542-3

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