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The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Polycystic ovary syndrome is heterogeneity disease, and the association with DEEND1A gene has been discussed incompatibly for a long time. We conducted a meta-analysis to evaluate the rs10818854, rs2479106, and rs10986105 polymorphism in DENND1A gene with PCOS susceptibility.

Methods

Meta-analysis was performed for common allele versus rare allele using random effect model on published papers from January 1, 1980 to October 1, 2015. Subgroup analysis, sensitivity analysis and publication bias were also carried out ultimately. The combined odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to estimate the strength of the association.

Results

The results showed that rs10818854 (OR = 1.36, 95 % CI 1.12–1.61) and rs10986105 (OR = 1.39, 95 % CI 1.20–1.58) polymorphism increased the risk of PCOS probably. A significant association was also found between rs2479106 mutation and Asian PCOS patients but not Europeans (OR = 1.32, 95 % CI 1.25–1.39; OR = 1.01, 95 % CI 0.97–1.05, respectively).

Conclusions

In conclusion, the DENND1A gene variant is likely to have influence on PCOS risk. Further studies are warranted to assess these associations in greater detail, especially in different populations and different subtype of PCOS patients.

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    Authors and Affiliations

    1. Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

      Jing Gao & Zhi-Chao Li

    2. Department of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China

      Jing Gao, Li Zhou & Chen Chen

    3. Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China

      Jing-Dong Xue

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    1. Jing Gao
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    Correspondence to Chen Chen.

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    J. Gao and J.-D. Xue contributed equally to this work.

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    Gao, J., Xue, JD., Li, ZC. et al. The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis. Arch Gynecol Obstet 294, 1073–1080 (2016). https://doi.org/10.1007/s00404-016-4159-x

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